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公开(公告)号：US20060121557A1
公开(公告)日：2006-06-08
申请号：US10528848
申请日：2003-09-23
申请人： Tatsuo Hoshino , Kazuyuki Ojima , Yutaka Setoguchi
发明人： Tatsuo Hoshino , Kazuyuki Ojima , Yutaka Setoguchi
CPC分类号： C12P23/00
摘要： Disclosed is a process for producing zeaxanthin and β-cryptoxanthin which comprises cultivating a recombinant microorganism which is expressing a β-carotene hydroxylase gene and belonging to the genus Xanthophyllomyces (Phaffia) in an aqueous nutrient medium under aerobic conditions, and isolating the resulted carotenoids from the cells of said recombinant microorganism or from the cultured broth.
摘要翻译： 公开了一种生产玉米黄质和β-隐黄质的方法，包括在需氧条件下，在含水营养培养基中培养表达β-胡萝卜素羟化酶基因并属于黄单胞菌属（Phanthia）属的重组微生物，并将得到的类胡萝卜素从 所述重组微生物的细胞或来自培养液的细胞。
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公开(公告)号：US06586202B2
公开(公告)日：2003-07-01
申请号：US09925388
申请日：2001-08-09
申请人： Tatsuo Hoshino , Kazuyuki Ojima , Yutaka Setoguchi
发明人： Tatsuo Hoshino , Kazuyuki Ojima , Yutaka Setoguchi
IPC分类号： C12N988
CPC分类号： C12N9/0004 , C12N9/1085 , C12N9/1205 , C12N9/88 , C12P23/00
摘要： The present invention relates to an isolated DNA sequence encoding an enzyme in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate. Vectors and plasmids including such DNA are also set forth. The invention also includes host cells transformed by such DNAs, or vectors or plasmids containing such DNAs. A process for the production of isoprenoids and carotenoids using such transformed host cells is also provided.
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公开(公告)号：US06365386B1
公开(公告)日：2002-04-02
申请号：US09518386
申请日：2000-03-03
申请人： Tatsuo Hoshino , Kazuyuki Ojima , Yutaka Setoguchi
发明人： Tatsuo Hoshino , Kazuyuki Ojima , Yutaka Setoguchi
IPC分类号： C12N900
摘要： The present invention is directed to genetic materials useful for the preparation of astaxanthin from beta-carotene, such as polypeptides having astaxanthin synthase activity, DNA fragments coding for astaxanthin synthase, recombinant organisms and the like. Those novel genetic materials may be derived from Phaffia rhodozyma. The present invention also provides a process for the production of astaxanthin.
摘要翻译： 本发明涉及可用于从β-胡萝卜素制备虾青素的遗传物质，例如具有虾青素合酶活性的多肽，编码虾青素合酶的DNA片段，重组生物体等。 这些新型遗传物质可以衍生自红发夫酵母（Phaffia rhodozyma）。 本发明还提供了生产虾青素的方法。
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公开(公告)号：US20070202501A1
公开(公告)日：2007-08-30
申请号：US10574045
申请日：2004-09-29
申请人： Kouji Matsushima , Shinichi Hashimoto , Masayuki Tsuchiya , Yuichi Hirata , Kenji Yoshida , Kazuyuki Ojima
发明人： Kouji Matsushima , Shinichi Hashimoto , Masayuki Tsuchiya , Yuichi Hirata , Kenji Yoshida , Kazuyuki Ojima
CPC分类号： C07K14/705 , A61K31/00 , G01N33/564 , G01N33/566 , G01N2500/00
摘要： Purified immunocytes were analyzed for expression frequencies, and the NKIR gene expressed specifically in natural killer (NK) cells was successfully identified. The NKIR gene encodes a receptor. Agonists and antagonists for the receptor can be identified by using the receptor.
摘要翻译： 分析纯化的免疫细胞的表达频率，并且成功鉴定了在自然杀伤（NK）细胞中特异表达的NKIR基因。 NKIR基因编码受体。 用于受体的激动剂和拮抗剂可以通过使用受体来鉴定。
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公开(公告)号：US08946386B2
公开(公告)日：2015-02-03
申请号：US10574045
申请日：2004-09-29
申请人： Kouji Matsushima , Shinichi Hashimoto , Masayuki Tsuchiya , Yuichi Hirata , Kenji Yoshida , Kazuyuki Ojima
发明人： Kouji Matsushima , Shinichi Hashimoto , Masayuki Tsuchiya , Yuichi Hirata , Kenji Yoshida , Kazuyuki Ojima
IPC分类号： A61K38/17 , C07K14/705 , A61K31/00 , G01N33/564 , G01N33/566
CPC分类号： C07K14/705 , A61K31/00 , G01N33/564 , G01N33/566 , G01N2500/00
摘要： Purified immunocytes were analyzed for expression frequencies, and the NKIR gene expressed specifically in natural killer (NK) cells was successfully identified. The NKIR gene encodes a receptor. Agonists and antagonists for the receptor can be identified by using the receptor.
摘要翻译： 分析纯化的免疫细胞的表达频率，并且成功鉴定了在自然杀伤（NK）细胞中特异表达的NKIR基因。 NKIR基因编码受体。 用于受体的激动剂和拮抗剂可以通过使用受体来鉴定。
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