公开(公告)号：US09493746B2

公开(公告)日：2016-11-15

申请号：US14504279

申请日：2014-10-01

Applicant: Samsung Electronics Co., Ltd. ,  AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Jinhwan Park ,  Pyungcheon Lee ,  Jaechan Park ,  Youngmin Lee ,  Wooyong Lee ,  Jinwoo Park ,  Kwangmyung Cho ,  Heejin Hwang

IPC: C12N9/02 ,  C12P7/24 ,  C12P7/18

CPC classification number: C12N9/0008 ,  C12P7/18 ,  C12P7/24 ,  C12Y102/01057 ,  Y02P20/52

Abstract: Recombinant butyraldehyde dehydrogenases (Blds) with improved production of 1,4-BDO, as well as recombinant microorganisms comprising polynucleotides encoding the recombinant Blds, and methods of producing 1,4-BDO by using the recombinant microorganisms.

公开(公告)号：US09447439B2

公开(公告)日：2016-09-20

申请号：US14468067

申请日：2014-08-25

Applicant: Samsung Electronics Co., Ltd.

Inventor： Youngmin Lee ,  Wooyong Lee ,  Jinwoo Kim ,  Jaechan Park ,  Jinhwan Park ,  Hwayoung Cho

IPC: C12P7/42 ,  C12N9/00 ,  C12P7/46 ,  C12N9/02 ,  C12P17/04

CPC classification number: C12P7/42 ,  C12N9/0008 ,  C12N9/93 ,  C12P7/46 ,  C12P17/04 ,  C12Y101/01027 ,  C12Y101/01061 ,  C12Y102/01002 ,  C12Y102/01024 ,  C12Y102/07003 ,  C12Y103/05 ,  C12Y108/01004 ,  C12Y203/01012 ,  C12Y208/03 ,  C12Y401/01 ,  C12Y604/01001 ,  Y02P20/52

Abstract: A genetically modified microorganism comprising a polynucleotide encoding α-ketoglutarate synthase or a mutant thereof, and a polynucleotide encoding pyruvate carboxylase or a mutant thereof; wherein the genetically modified microorganism has decreased malate quinone oxidoreductase activity and/or decreased phosphoenolpyruvate carboxykinase activity compared to an unmodified microorganism of the same type, and wherein the genetically modified microorganism produces 4-hydroxybutyrate.

Abstract translation: 一种遗传修饰微生物，其包含编码α-酮戊二酸合酶或其突变体的多核苷酸，以及编码丙酮酸羧化酶或其突变体的多核苷酸; 其中所述遗传修饰的微生物与相同类型的未修饰的微生物相比，具有降低的苹果酸醌氧化还原酶活性和/或降低的磷酸烯醇丙酮酸羧激酶活性，并且其中所述经遗传修饰的微生物产生4-羟基丁酸酯。

公开(公告)号：US20150044745A1

公开(公告)日：2015-02-12

申请号：US14456754

申请日：2014-08-11

Applicant: Samsung Electronics Co., Ltd.

Inventor： Soonchun CHUNG ,  Joonsong Park ,  Jinhwan Park ,  Jiae Yun ,  Jaechan Park ,  Kwangmyung Cho

IPC: C12P7/46 ,  C12N9/88

CPC classification number: C12P7/46 ,  C12N9/88 ,  C12Y402/01002

Abstract: A recombinant Corynebacterium genus microorganism, and a method of producing C4 dicarboxylic acid under anaerobic conditions using the Corynebacterium genus microorganism.

Abstract translation: 重组棒状杆菌属微生物，以及使用棒状杆菌属微生物在厌氧条件下生产C4二羧酸的方法。