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29 条记录 (耗时 0.022 秒)

    Method of production and use of crotoxin as an analgesic
    11.
    发明申请
    Method of production and use of crotoxin as an analgesic 审中-公开
    生产和使用毒素作为镇痛药的方法

    公开(公告)号：US20060034823A1

    公开(公告)日：2006-02-16

    申请号：US10917143

    申请日：2004-08-13

    申请人： Paul Reid ,  Zheng Qin

    发明人： Paul Reid ,  Zheng Qin

    IPC分类号： A61K38/48 ,  A61K31/60

    CPC分类号： A61K38/465 ,  A61K31/60 ,  C12Y301/01004 ,  A61K2300/00

    摘要： Disclosed a pharmaceutical composition including one of crotoxin, mojavetoxin or a related toxin and a carrier for use in the treatment of chronic pain, especially to the treatment of heretofore intractable pain such as that associated with advanced cancer wherein the treatment is independent of the reduction of tumors. The crotoxin is preferably obtained from the snake Crotalus durissus terrificus and the mojavetoxin is obtained from the rattlesnake Crotalus scutulatus scutulatus. Preferably the composition further comprises an effective amount of acetylsalicylic acid whereby the toxin and acetylsalicylic acid together produce a synergistic effect providing enhanced pain relief. The composition of the invention may be delivered in parenteral (i.p.) (intravenous, intramuscular or subcutaneous) applications. Alternatively, the composition may be applied as a topical application. The biological activity of the composition is characterized by its ability to bind to presynaptic and postsynapic receptor sites. This results in an inhibition of aceylcholine release and activity.

    摘要翻译： 本发明公开了一种药物组合物，其中包括一种抗生素，莫霍伊金或相关毒素，以及用于治疗慢性疼痛的载体，特别是治疗与晚期癌症相关的先天难治性疼痛，其中治疗独立于晚期癌症的降低 肿瘤。 该抗氧化蛋白质优选从蛇形龙胆（Crotalus durissus terrificus）中获得，并且鼠尾草毒素是从响尾蛇（Crotalus scutulatus scutulatus）获得的。 优选地，组合物还包含有效量的乙酰水杨酸，由此毒素和乙酰水杨酸一起产生协同效应，提供增强的疼痛缓解。 本发明的组合物可以肠胃外（腹膜内）（静脉内，肌内或皮下）应用递送。 或者，组合物可以作为局部应用施用。 组合物的生物活性的特征在于其与突触前和突触后受体位点结合的能力。 这导致乙酰胆碱释放和活性的抑制。

    Kelp/seaweed extract biocatalyst and methods of making same
    13.
    发明授权
    Kelp/seaweed extract biocatalyst and methods of making same 失效
    海带/海藻提取物生物催化剂及其制备方法

    公开(公告)号：US06284012B1

    公开(公告)日：2001-09-04

    申请号：US09193496

    申请日：1998-11-16

    申请人： David D. Mundschenk ,  Paul Reid

    发明人： David D. Mundschenk ,  Paul Reid

    IPC分类号： C05F1100

    CPC分类号： C05G3/0064 ,  C05F11/00

    摘要： Kelp/seaweed extract biocatalyst compositions, methods of making the kelp/seaweed extract biocatalyst compositions and methods of using these biocatalyst compositions are disclosed. The biocatalyst compositions are useful in wastewater treatment, bioremediation and the elimination of grease from grease traps and sewage systems. In addition, the biocatalyst compositions are useful in home, garden and lawn care applications.

    摘要翻译： 海藻提取物生物催化剂组合物，海藻/海藻提取物生物催化剂组合物的制备方法和使用这些生物催化剂组合物的方法。 生物催化剂组合物可用于废水处理，生物修复和消除油脂捕集器和污水系统中的油脂。 此外，生物催化剂组合物可用于家庭，花园和草坪护理应用。

    CARRYING SKI EQUIPMENT
    14.
    发明申请
    CARRYING SKI EQUIPMENT 审中-公开

    公开(公告)号：US20180193719A1

    公开(公告)日：2018-07-12

    申请号：US15328295

    申请日：2015-07-23

    申请人： Paul Reid

    发明人： Paul Reid

    IPC分类号： A63C11/02 ,  A45F5/02

    CPC分类号： A63C11/025 ,  A45F3/14 ,  A45F5/00 ,  A45F5/021 ,  A45F2005/026 ,  A63C11/02

    摘要： An apparatus and a method for carrying skis are disclosed. The skis are encircled with a strap to form a bundle. The bundle is releasably attached to a belt or bandolier worn by a person. The strap carries an engagement member, and the belt or bandolier carrying a holder with which the engagement member is adapted releasably to engage.

    Wellbore treatment apparatus and method
    16.
    发明授权
    Wellbore treatment apparatus and method 失效
    井筒处理装置及方法

    公开(公告)号：US07424912B2

    公开(公告)日：2008-09-16

    申请号：US11618091

    申请日：2006-12-29

    申请人： Paul Reid

    发明人： Paul Reid

    IPC分类号： E21B43/25 ,  E21B47/08

    CPC分类号： E21B47/08 ,  E21B17/1021 ,  E21B33/138

    摘要： A treatment apparatus and method for wellbore instability is described including a caliper with one or more radially extending arms which are capable of extending and retracting movement in a radial direction and a fluid supply facility to deliver treatment fluid from the ends of the arms to the wellbore wall, with a sensing and valve mechanism such that in use fluid is being delivered from the end of any extended arm to a breakout region of the wellbore where there is instability.

    摘要翻译： 描述了一种用于井筒不稳定性的处理装置和方法，其包括具有一个或多个径向延伸的臂的卡钳，其能够沿径向方向延伸和缩回运动，以及流体供应设施，以将治疗流体从臂的端部输送到井筒 具有感测和阀机构，使得在使用中，流体从任何延伸的臂的端部被输送到井筒的不稳定的断裂区域。

    Use of crotoxin as an analgesic - CIP
    18.
    发明申请
    Use of crotoxin as an analgesic - CIP 审中-公开
    使用抗氧化剂作为镇痛药 - CIP

    公开(公告)号：US20070148159A1

    公开(公告)日：2007-06-28

    申请号：US11313377

    申请日：2005-12-22

    申请人： Paul Reid ,  Zheng Qin

    发明人： Paul Reid ,  Zheng Qin

    IPC分类号： A61K38/48 ,  A61K31/60

    CPC分类号： A61K38/1703 ,  A61K31/60

    摘要： A method of producing analgesia and enhancing analgesia is disclosed. The method includes administering a beta-neurotoxin that is characterized by its ability to bind to pre- and postsynaptic receptors resulting in the inhibition of neurotransmission.

    摘要翻译： 公开了一种制备镇痛和增强止痛的方法。 该方法包括施用β-神经毒素，其特征在于其结合前和突触后受体的能力，导致神经传递的抑制。

    Modified venom and venom components as anti-retroviral agents
    19.
    发明申请
    Modified venom and venom components as anti-retroviral agents 审中-公开
    改良的毒液和毒液组分作为抗逆转录病毒剂

    公开(公告)号：US20060088843A1

    公开(公告)日：2006-04-27

    申请号：US10883834

    申请日：2004-10-25

    申请人： Paul Reid ,  Laurence Raymond

    发明人： Paul Reid ,  Laurence Raymond

    IPC分类号： C12Q1/70 ,  C12Q1/68

    CPC分类号： A61K38/1703

    摘要： The present invention relates to a class of proteins, a process of production thereof, and a method for treatment of neurological and viral diseases in humans and animals. More specifically it applies to the treatment of heretofore intractable diseases such as retro-viral infections including human immunodeficiency virus (HIV), simian immunodeficiency virus (SIV), feline immunodeficiency virus (FIV), bovine immunodeficiency virus (BIV) and equine acquired immunodeficiency virus (EAIV). The method of treatment comprises administering to the subject a disease mitigating amount of a detoxified and neurotropically active modified venom composition containing alpha-neurotoxins that target a nicotinic acetylcholine receptor.

    摘要翻译： 本发明涉及一类蛋白质，其生产方法，以及治疗人和动物神经病毒和病毒性疾病的方法。 更具体地说，它适用于治疗迄今为止的难治性疾病，例如包括人类免疫缺陷病毒（HIV），猿猴免疫缺陷病毒（SIV），猫免疫缺陷病毒（FIV），牛免疫缺陷病毒（BIV）和马获得性免疫缺陷病毒 （EAIV）。 治疗方法包括向受试者施用减轻剂量的含有靶向烟碱乙酰胆碱受体的α-神经毒素的解毒和神经行为活化的修饰的毒液组合物。

    Method of use of crotoxin as an anti-retroviral agent
    20.
    发明申请
    Method of use of crotoxin as an anti-retroviral agent 审中-公开
    使用抗氧化剂作为抗逆转录病毒剂的方法

    公开(公告)号：US20060045875A1

    公开(公告)日：2006-03-02

    申请号：US10934594

    申请日：2004-09-02

    申请人： Paul Reid

    发明人： Paul Reid

    IPC分类号： A61K38/48 ,  C07K14/47

    CPC分类号： A61K38/465 ,  C12Y301/01004

    摘要： The present invention provides a composition of matter and a method of using the composition for treating and preventing of retroviral infections of mammalian cells. It includes identification of Crotalus beta-neurotoxins as capable of preventing HIV infection and replication in that cell and a retroviral composition which can be administered in-vivo for the treatment of HIV infection. The retrovirus is selected from the group consisting of Lentiviruses (HIV-1, HIV-2, SIV, EIAV, BIV, and FIV). In addition, crotoxin can effect changes to the expression of HIV receptor proteins and/or cellular cofactors homologous to their target receptors.

    摘要翻译： 本发明提供了一种物质组合物和使用该组合物治疗和预防哺乳动物细胞的逆转录病毒感染的方法。 它包括鉴定能够预防HIV感染和复制的Crotalusβ-神经毒素以及可以在体内施用以治疗HIV感染的逆转录病毒组合物。 逆转录病毒选自慢病毒（HIV-1，HIV-2，SIV，EIAV，BIV和FIV）。 此外，克罗克毒素可以影响与其目标受体同源的HIV受体蛋白和/或细胞辅因子的表达的变化。