公开(公告)号：US20140028824A1

公开(公告)日：2014-01-30

申请号：US13942933

申请日：2013-07-16

Applicant: OLYMPUS MEDICAL SYSTEMS CORP. ,  OLYMPUS CORPORATION

Inventor： Kei KUBO ,  Yasushige ISHIHARA ,  Hiromi SHIDA ,  Satoshi TAKEKOSHI

IPC: A61B5/00

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646

Abstract: Provided is a fluoroscopy apparatus including a fluorescence-image generating portion that generates a fluorescence image; an identifying portion that identifies a position of a high-luminance region in the fluorescence image; a storage portion that stores the position of the high-luminance region; a detecting portion that detects an amount of change in a physical quantity, which can possibly act as a cause of changes in a property of the high-luminance region, starting from a time at which the position of the high-luminance region is identified by the identifying portion; a confidence-level calculating portion that calculates a confidence level of the property of the high-luminance region based on the detected amount of change; and a display-image generating portion that generates a display image in which the display mode at the position of the high-luminance region is set in accordance with the confidence level.

Abstract translation: 本发明提供一种荧光透视设备，包括产生荧光图像的荧光图像产生部分; 识别部，其识别所述荧光图像中的高亮度区域的位置; 存储部，其存储高亮度区域的位置; 检测部分，其从高亮度区域的位置的时间开始，从高亮度区域的位置开始，检测出物理量的变化量，其可能充当高亮度区域的性质变化的原因， 识别部分; 置信度计算部，其基于检测出的变化量来计算高亮度区域的属性的置信度; 以及显示图像生成部，其生成根据置信水平设定高亮度区域的位置的显示模式的显示图像。

公开(公告)号：US20140024948A1

公开(公告)日：2014-01-23

申请号：US14033687

申请日：2013-09-23

Applicant: OLYMPUS CORPORATION

Inventor： Hiromi SHIDA ,  Yasushige ISHIHARA

IPC: A61B5/00

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  G02B23/2469 ,  G02B2207/113

Abstract: Provided is a fluoroscopy apparatus including a fluorescence imaging portion that acquires a fluorescence image of biological tissue; a return-light imaging portion that acquires a return-light image of the biological tissue; a fluorescence-region identifying portion that identifies a fluorescence region in the fluorescence image by using a processing condition specified from among a plurality of processing conditions; a superimposed-image generating portion that generates a superimposed image by superimposing the identified fluorescence region on a corresponding position in the return-light image; a treatment-information acquisition portion that acquires treatment-details information indicating the specifics of treatment to be applied to the biological tissue; and an image switching portion that specifies the processing condition to be used by the fluorescence-region identifying portion in accordance with the treatment-details information acquired by the treatment-information acquisition portion.

Abstract translation: 本发明提供一种荧光检查装置，其具备获取生物体组织的荧光图像的荧光成像部， 获取生物组织的返回光图像的返回光成像部分; 荧光区域识别部，其通过使用从多个处理条件中指定的处理条件来识别所述荧光图像中的荧光区域; 叠加图像生成部，其通过将识别的荧光区域叠加在返回光图像的对应位置上来生成叠加图像; 治疗信息获取部，其获取表示应用于所述生物体组织的治疗的细节的治疗细节信息; 以及图像切换部，其根据由治疗信息获取部获取的治疗细节信息来指定荧光区域识别部使用的处理条件。

公开(公告)号：US20130314520A1

公开(公告)日：2013-11-28

申请号：US13956447

申请日：2013-08-01

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige ISHIHARA

IPC: H04N7/18

CPC classification number: H04N7/18 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/045 ,  G01N21/6456 ,  G01N2021/6484 ,  H04N2005/2255

Abstract: Observation is performed at a more appropriate sensitivity without reducing an image quality. Provided is a fluorescence observation device (1) including: an excitation light source (3) that emits excitation light to be radiated onto a subject (A); a fluorescence-image acquiring section (21) provided with an imaging element (18) that acquires a fluorescence image (G2) by imaging fluorescence produced in the subject (A) when the excitation light emitted from the excitation light source (3) is radiated onto the subject (A); and a sensitivity adjusting section (22) that adjusts, based on luminance information of the fluorescence image (G2) acquired by the imaging element (18) of the fluorescence-image acquiring section (21), a number of pixels for binning summing (B) and/or an exposure time (t) in the imaging element (18) such that a SN ratio of the fluorescence image (G2) is equal to or larger than a predetermined threshold.

Abstract translation: 以更合适的灵敏度进行观察，而不会降低图像质量。 本发明提供一种荧光观察装置（1），其特征在于，包括：发射被照射到被检体（A）上的激发光的激发光源（3）。 荧光图像获取部分（21）具有成像元件（18），当从激发光源（3）发出的激发光被照射时，成像元件（18）通过成像对象（A）中产生的荧光来获取荧光图像（G2） （A）; 以及灵敏度调整部（22），其基于由所述荧光图像获取部（21）的摄像元件（18）获取的荧光图像（G2）的亮度信息，调整用于合并求和的像素数（B ）和/或成像元件（18）中的曝光时间（t），使得荧光图像（G2）的SN比等于或大于预定阈值。

公开(公告)号：US20130028501A1

公开(公告)日：2013-01-31

申请号：US13645083

申请日：2012-10-04

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige ISHIHARA

IPC: G06K9/00

CPC classification number: A61B6/504 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/05 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  G06T5/009 ,  G06T5/50

Abstract: A fluoroscopy device includes a light source that irradiates an observation site with excitation light and white light; a fluorescence-image generating section that acquires a fluorescence image by capturing fluorescence generated in the observation site irradiated with the excitation light; a reference-image generating section that acquires a reference image by capturing return light returning from the observation site irradiated with the white light; an observation-condition determining section that determines the observation conditions of the observation site on the basis of the reference image acquired by the reference-image generating section; a preprocessing section that corrects gradation values of the reference image on the basis of the observation conditions of the observation site; and a fluorescence-image correcting section that generates a corrected fluorescence image by dividing the fluorescence image acquired by the fluorescence-image generating section by the reference image whose gradation values have been corrected by the preprocessing section.

Abstract translation: 荧光透视装置包括：用激发光和白光照射观察部位的光源; 荧光图像生成部，其通过捕获在被激发光照射的观察部位中产生的荧光获取荧光图像; 参考图像生成部，其通过捕获从所述观察部位返回的从所述白光照射的返回光获取参照图像; 观察条件确定部，其基于由参考图像生成部获取的参考图像来确定观察部位的观察条件; 基于所述观察部位的观察条件来校正所述参照图像的灰度值的预处理部; 以及荧光图像校正部，其通过将由所述荧光图像生成部获取的荧光图像除以由所述预处理部修正了灰度值的参照图像来生成校正后的荧光图像。

公开(公告)号：US20160262622A1

公开(公告)日：2016-09-15

申请号：US15163739

申请日：2016-05-25

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige ISHIHARA

IPC: A61B5/00 ,  A61B1/04 ,  A61B1/06

CPC classification number: A61B5/0071 ,  A61B1/04 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/7425 ,  A61B2562/0233

Abstract: A fluorescence observation apparatus comprising a light source having a single light-emitting portion for emitting white light and excitation light simultaneously and radiates the white light and the excitation light; a light guide that guides the radiated white and excitation lights and simultaneously irradiates the white and excitation lights light onto a specimen; a white-light-image acquisition unit that receives return light of the white light coming from the specimen and acquires a white-light image; a fluorescence-image acquisition unit that receives fluorescence excited in the specimen by the excitation light and acquires a fluorescence image; an illumination-light filter that is disposed between the light-emitting portion and a radiation exit end of the light source, and satisfies the following conditional expression, Pf(λw)

Abstract translation: 一种荧光观察装置，包括具有同时发出白光和激发光的单个发光部的光源，并且发射白光和激发光; 引导辐射的白光和激发光的同时将白色和激发光照射到样品上的光导体; 白光图像获取单元，其接收来自所述样本的白光的返回光并获取白光图像; 荧光图像获取单元，其通过所述激发光接收在所述样本中激发的荧光并获取荧光图像; 设置在光源的发光部和发光出射端之间的照明光滤光器，满足以下条件式Pf（λw）

公开(公告)号：US20160157722A1

公开(公告)日：2016-06-09

申请号：US15046860

申请日：2016-02-18

Applicant: OLYMPUS CORPORATION

Inventor： Kei KUBO ,  Yasushige ISHIHARA

IPC: A61B5/00

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  A61B1/045 ,  A61B1/0638 ,  A61B1/0646 ,  G06T5/008 ,  G06T5/50 ,  G06T19/006 ,  G06T19/20 ,  G06T2207/10064 ,  G06T2207/10068 ,  G06T2207/20212

Abstract: A fluorescence observation apparatus including a light source that radiates illumination light and excitation light; a return-light-image generating portion and a fluorescence-image generating portion that generate a return-light image and a fluorescence image, respectively; a fluorescence detecting portion that detects a fluorescence region in the fluorescence image; a return-light-image adjusting portion that adjusts gradation values of the return-light image; a superimposed-image generating portion that generates a superimposed image by using the return-light image, in which the gradation values have been adjusted, and the fluorescence image; and a coefficient setting portion that sets, in the case in which the fluorescence region is detected, a degree-of-reduction of the gradation values, so that the gradation values of the return-light image are decreased as compared with the case in which the fluorescence region is not detected.

Abstract translation: 一种荧光观察装置，包括：照射光和激发光的光源; 分别产生返回光图像和荧光图像的返回光图像生成部分和荧光图像生成部分; 荧光检测部，其检测所述荧光图像中的荧光区域; 返回光图像调整部，其调整返回光图像的灰度值; 通过使用调整了灰度值的返回光图像和荧光图像来生成叠加图像的叠加图像生成部; 以及系数设定部，其在检测出荧光区域的情况下，设定灰度值的减小度，使得返回光图像的灰度值与以下情况相比降低： 不检测荧光区域。

公开(公告)号：US20140301617A1

公开(公告)日：2014-10-09

申请号：US14312956

申请日：2014-06-24

Applicant: OLYMPUS CORPORATION ,  OLYMPUS MEDICAL SYSTEMS CORP.

Inventor： Hiromi SHIDA ,  Yasushige ISHIHARA ,  Satoshi TAKEKOSHI ,  Kei KUBO

IPC: G06T7/00 ,  G06K9/46

CPC classification number: G06T7/0014 ,  A61B1/00009 ,  A61B1/043 ,  G02B21/16 ,  G02B23/2461 ,  G02B23/2484 ,  G06K9/46 ,  G06K2009/4666

Abstract: Fluorescence generated at a lesion is distinguished from fluorescence generated at portions other than the lesion, and thus, observation is performed by using only the fluorescence generated at the lesion. Provided is a fluorescence observation apparatus including a light radiating portion that radiates excitation light onto an examination subject; a fluorescence-distribution acquiring portion that acquires an intensity distribution of fluorescence generated at the examination subject due to irradiation with the excitation light from the light radiating portion; and a non-target-region excluding portion that, in the fluorescence-intensity distribution acquired by the fluorescence-distribution acquiring portion, excludes regions in which a spectrum in a specific wavelength band has changed due to a specific biological component whose concentration in a lesion is lower than in other portions.

Abstract translation: 在损伤处产生的荧光与病变以外的部分产生的荧光不同，因此仅使用在病变处产生的荧光进行观察。 本发明提供一种荧光观察装置，其包括将激发光照射到检查对象上的光照射部， 荧光分布获取部分，其获取由于来自所述光辐射部分的激发光的照射而在所述检查对象产生的荧光的强度分布; 以及在由荧光分布获取部获取的荧光强度分布中排除由特定生物成分在特定波长带中的光谱变化的区域的非靶区域排除部分， 低于其他部分。

公开(公告)号：US20140184769A1

公开(公告)日：2014-07-03

申请号：US14198671

申请日：2014-03-06

Applicant: OLYMPUS MEDICAL SYSTEMS CORP. ,  OLYMPUS CORPORATION

Inventor： Yasushige ISHIHARA ,  Hiromi SHIDA ,  Kei KUBO ,  Satoshi TAKEKOSHI

IPC: G01N21/64

CPC classification number: G01N21/64 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  G01N21/6456 ,  G06T5/50 ,  G06T2207/20216

Abstract: Provided is a fluorescence observation apparatus including: a fluorescence image acquisition section and a reference image acquisition section that acquire a fluorescence image and a reference image of a subject, respectively; a division image generation section that generates a division image by dividing an image based on the fluorescence image by an image based on the reference image; a display section that displays a corrected fluorescence image based on the division image; a correction processing section that applies correction processing to at least one of the reference image and the fluorescence image and/or to the division image prior to the generation of the division image or prior to the display of the corrected fluorescence image; an observation condition determination section that determines observation conditions of the subject; and a correction condition setting section that sets parameters regarding the correction processing according to the observation conditions.

Abstract translation: 本发明提供一种荧光观察装置，包括：荧光图像获取部和参考图像获取部，分别获取被检体的荧光图像和参照图像; 分割图像生成部，其通过基于所述参照图像将基于所述荧光图像的图像分割为图像来生成分割图像; 显示部，其基于所述分割图像显示校正的荧光图像; 校正处理部，其在所述分割图像的生成之前或所述校正后的荧光图像的显示之前，对所述参考图像和所述荧光图像和/或所述分割图像中的至少一个进行校正处理; 观察条件确定部，其确定被检体的观察条件; 以及校正条件设定部，其根据观察条件设定关于校正处理的参数。

公开(公告)号：US20140098207A1

公开(公告)日：2014-04-10

申请号：US14100422

申请日：2013-12-09

Applicant: Olympus Corporation

Inventor： Yasushige ISHIHARA

IPC: A61B1/04 ,  G06T5/00

CPC classification number: G06T5/006 ,  A61B1/0005 ,  A61B1/00059 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/05 ,  A61B1/0646 ,  A61B1/0669

Abstract: There is provided a fluorescence observation apparatus, including: a lighting section including a light source emitting illumination light and excitation light; a fluorescence imaging section picking up fluorescence generated on a subject and acquiring a fluorescence image; a returned light imaging section picking up returned light returned from the subject and acquiring a returned light image; a preprocessing section multiplying at least either the fluorescence image or the returned light image by a coefficient in which a distance property of fluorescence intensity and a distance property of returned light intensity, which are acquired in advance with respect to a standard sample, come to be in a relation directly proportional to each other and generating a fluorescence image for correction and a returned light image for correction; and a fluorescence image correction section dividing the fluorescence image for correction by the returned light image for correction.

Abstract translation: 提供了一种荧光观察装置，包括：发光部，其具备发出照明光和激发光的光源; 荧光成像部，其拾取对象产生的荧光并获取荧光图像; 返回的光成像部拾取从被检体返回的返回光并获取返回的光图像; 至少将荧光图像或返回的光图像乘以其中相对于标准样品预先获取的荧光强度的距离属性和返回光强度的距离属性的系数成为的预处理部分 以相互直接成比例的关系产生用于校正的荧光图像和用于校正的返回光图像; 以及荧光图像校正部，将用于校正的荧光图像除以所述返回光图像进行校正。

公开(公告)号：US20140085686A1

公开(公告)日：2014-03-27

申请号：US14093806

申请日：2013-12-02

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige ISHIHARA

IPC: H04N1/028

CPC classification number: H04N1/02815 ,  A61B1/00009 ,  A61B1/00039 ,  A61B1/043 ,  A61B1/0638

Abstract: The probability of extracting a region containing a large amount of fluorescent material is increased in accordance with the kind of fluorescent reagent etc. A fluorescence observation device includes an illuminating unit irradiating a subject with excitation light and illumination light; a fluorescence image capturing unit acquiring a fluorescence image by capturing fluorescence generated at the subject a return-light image capturing unit acquiring a return-light image by capturing return light returned from the subject; an extracting unit determining and extracting a region having a gray level exceeding a gray-level threshold from the fluorescence image as a region-of-interest; a display unit displaying the region-of-interest and the return-light image in association with each other; a true/false input unit prompting an observer to enter true or false as to the determination of the region-of-interest; and a threshold updating unit updating the gray-level threshold so as to reflect the input result entered.

Abstract translation: 提取含有大量荧光材料的区域的概率根据荧光试剂等的种类而增加。荧光观察装置包括用激发光和照明光照射对象的照明单元。 荧光图像捕获单元，通过捕获在所述对象处生成的荧光图像，所述荧光图像通过捕获从所述对象返回的返回光来获取所述返回光图像，所述返回光图像捕获单元获取所述返回光图像; 提取单元从所述荧光图像确定并提取具有超过灰度级阈值的灰度级的区域作为所述兴趣区域; 显示单元，其显示相关联的感兴趣区域和返回光图像; 一个真/假输入单元，促使观察者对确定利益感兴趣区域进行真实或虚假的输入; 以及阈值更新单元，更新灰度级阈值，以便反映输入的输入结果。