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公开(公告)号:US11450406B2
公开(公告)日:2022-09-20
申请号:US16998006
申请日:2020-08-20
发明人: Eran Eden , Kfir Oved , Roy Navon , Assaf Cohen-Dotan , Olga Boico
IPC分类号: G16B5/20 , G16B5/00 , G16B20/00 , G16B40/00 , G16B20/20 , G16B40/30 , G16B25/10 , G16B40/20 , G16H50/50 , G06F17/18 , G16B25/00 , G01N33/569
摘要: A method of analyzing biological data containing expression values of a plurality of polypeptides in the blood of a subject. The method comprises: calculating a distance between a segment of a curved line and an axis defined by a direction, the distance being calculated at a point over the curved line defined by a coordinate along the direction. The method further comprises correlating the distance to the presence of, absence of, or likelihood that the subject has, a bacterial infection. The coordinate is defined by a combination of the expression values, wherein at least 90% of the segment is between a lower bound line and an upper bound line.
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公开(公告)号:US11385241B2
公开(公告)日:2022-07-12
申请号:US16334033
申请日:2017-09-27
发明人: Eran Eden , Kfir Oved , Assaf Cohen-Dotan , Roy Navon , Olga Boico , Meital Paz
IPC分类号: G01N33/50 , G01N33/52 , G01N33/53 , G01N33/60 , G01N33/68 , G16H50/30 , G16H50/70 , G16H50/20 , G01N33/58 , C07K14/47 , C07K14/525 , C07K14/54 , C07K14/52
摘要: A method of determining a management course for treating a subject showing symptoms of a disease is disclosed. The method comprises measuring the TRAIL protein level in a blood sample of the subject, wherein when the TRAIL level is below a predetermined amount, the subject is treated as a high-risk patient.
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公开(公告)号:US11466331B2
公开(公告)日:2022-10-11
申请号:US16081906
申请日:2017-03-02
发明人: Kfir Oved , Eran Eden , Olga Boico , Gali Kronenfeld , Roy Navon , Assaf Cohen-Dotan , Einav Simon
IPC分类号: C12Q1/70 , C12Q1/689 , G01N33/569 , C12Q1/00
摘要: Methods of determining infection type are disclosed. In one embodiment, the method comprises measuring the amount of a determinant which is set forth in Tables 1 or 2 in a sample derived from the subject, wherein said amount is indicative of the infection type.
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公开(公告)号:US11131671B2
公开(公告)日:2021-09-28
申请号:US16238582
申请日:2019-01-03
发明人: Eran Eden , Kfir Oved , Assaf Cohen-Dotan , Roy Navon , Olga Boico , Gali Kronenfeld , Meital Paz , Ellen Bamberger
IPC分类号: C07K14/525 , C07K14/555 , C07K14/575 , G01N33/52 , G01N33/53 , G01N33/535 , G01N33/547 , G01N33/68 , G01N33/569 , G01N33/50 , C07K14/54 , C07K16/12 , C07K16/24 , C07K16/26 , G01N33/577 , G16B20/00 , G16B40/00
摘要: Methods of diagnosing infections are disclosed. In one embodiment, the method comprises measuring the amount of each of the polypeptides TRAIL, CRP, IP10 and at least one additional polypeptide selected from the group consisting of IL-6 and PCT.
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公开(公告)号:US11081206B2
公开(公告)日:2021-08-03
申请号:US16355984
申请日:2019-03-18
发明人: Eran Eden , Kfir Oved , Roy Navon , Assaf Cohen-Dotan , Olga Boico
摘要: A method of analyzing biological data containing expression values of a plurality of polypeptides in the blood of a subject. The method comprises: calculating a distance between a segment of a curved line and an axis defined by a direction, the distance being calculated at a point over the curved line defined by a coordinate along the direction. The method further comprises correlating the distance to the presence of, absence of, or likelihood that the subject has, a bacterial infection. The coordinate is defined by a combination of the expression values, wherein at least 90% of the segment is between a lower bound line and an upper bound line.
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公开(公告)号:US10303846B2
公开(公告)日:2019-05-28
申请号:US15503439
申请日:2015-08-12
发明人: Eran Eden , Kfir Oved , Roy Navon , Assaf Cohen-Dotan , Olga Boico
摘要: A method of analyzing biological data containing expression values of a plurality of polypeptides in the blood of a subject. The method comprises: calculating a distance between a segment of a curved line and an axis defined by a direction, the distance being calculated at a point over the curved line defined by a coordinate along the direction. The method further comprises correlating the distance to the presence of, absence of, or likelihood that the subject has, a bacterial infection. The coordinate is defined by a combination of the expression values, wherein at least 90% of the segment is between a lower bound line and an upper bound line.
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