公开(公告)号：US20200063082A1

公开(公告)日：2020-02-27

申请号：US16673805

申请日：2019-11-04

Applicant: Massachusetts Institute of Technology ,  Sanofi

Inventor： Shireen Goh ,  Rajeev Jagga Ram ,  Michelangelo Canzoneri ,  Horst Blum

IPC: C12M3/06 ,  C12M1/00 ,  C12M1/34

Abstract: Control of volume in bioreactors and associated systems is generally described. Feeding and/or sampling strategies can be employed, in some embodiments, such that the working volume within the bioreactor remains substantially contstant.

公开(公告)号：US20140127802A1

公开(公告)日：2014-05-08

申请号：US14063967

申请日：2013-10-25

Applicant: Massachusetts Institute of Technology

Inventor： Shireen Goh ,  Rajeev Jagga Ram ,  Michelangelo Canzoneri ,  Horst Blum

IPC: C12M1/34 ,  C12M1/00

CPC classification number: C12M41/34 ,  B01L3/502723 ,  C12M23/24 ,  C12M23/26 ,  C12M23/34 ,  C12M29/04 ,  C12M41/26 ,  C12M41/32 ,  C12M41/44

Abstract: Strategies to control the level of dissolved carbon dioxide (CO2) concentrations and/or pH in small volume reactor chambers, and associated articles, systems, and methods, are generally provided. In certain embodiments, the reactor chambers can be configured to contain at least one biological cell.

Abstract translation: 通常提供了控制小体积反应器室中的溶解二氧化碳（CO 2）浓度和/或pH值以及相关物品，系统和方法的策略。 在某些实施方案中，反应器室可被配置成容纳至少一个生物细胞。