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公开(公告)号：US07544677B2
公开(公告)日：2009-06-09
申请号：US11659606
申请日：2005-08-19
Applicant: Mark T. Bilodeau , Nicholas D. P. Cosford , John C. Hartnett , Yiwei Li , Jun Liang , Peter J. Manley , Lou Anne Neilson , Tony Siu , Zhicai Wu
Inventor： Mark T. Bilodeau , Nicholas D. P. Cosford , John C. Hartnett , Yiwei Li , Jun Liang , Peter J. Manley , Lou Anne Neilson , Tony Siu , Zhicai Wu
IPC: A61K31/541 , A61K31/5355 , A61K31/519 , C07D471/04 , C07D519/00 , A61P35/00
CPC classification number: C07D471/04
Abstract: The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
Abstract translation: 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代的5-取代哌啶部分的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。
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公开(公告)号：US20090069312A1
公开(公告)日：2009-03-12
申请号：US12223353
申请日：2007-01-29
Applicant: B. Wesley Trotter , Richard C.A. Isaacs , Zhicai Wu , Jacob M. Hoffman , Mark T. Bilodeau , Ahren Iver Green
Inventor： B. Wesley Trotter , Richard C.A. Isaacs , Zhicai Wu , Jacob M. Hoffman , Mark T. Bilodeau , Ahren Iver Green
IPC: A61K31/538 , C07D413/14 , A61P9/06
CPC classification number: C07D413/14
Abstract: The present invention relates to dipyridin-3-ylmethoxy compounds and derivatives thereof having the structure I useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
Abstract translation: 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构I的二吡啶-3-基甲氧基化合物及其衍生物等。
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公开(公告)号：US20090030043A1
公开(公告)日：2009-01-29
申请号：US12223356
申请日：2007-01-29
Applicant: Jacob M. Hoffman , Anthony M. Smith , John Hartnett , Zhicai Wu , Mark T. Bilodeau
Inventor： Jacob M. Hoffman , Anthony M. Smith , John Hartnett , Zhicai Wu , Mark T. Bilodeau
IPC: A61K31/444 , C07D401/14
CPC classification number: C07D213/74
Abstract: The present invention relates to tetraaryl methyl amine compounds and derivatives thereof having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
Abstract translation: 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构（I）的四芳基甲胺化合物及其衍生物等。
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公开(公告)号：US07879839B2
公开(公告)日：2011-02-01
申请号：US11658114
申请日：2005-07-27
Applicant: Christopher J. Dinsmore , Jeffrey M. Bergman , Douglas C. Beshore , B. Wesley Trotter , Kausik K. Nanda , Richard Isaacs , Linda S. Payne , Lou Anne Neilson , Zhicai Wu , Mark T. Bilodeau , Peter J. Manley , Adrienne E. Balitza
Inventor： Christopher J. Dinsmore , Jeffrey M. Bergman , Douglas C. Beshore , B. Wesley Trotter , Kausik K. Nanda , Richard Isaacs , Linda S. Payne , Lou Anne Neilson , Zhicai Wu , Mark T. Bilodeau , Peter J. Manley , Adrienne E. Balitza
IPC: C07D401/14 , A61K31/438
CPC classification number: C07D213/36 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/55 , C07D213/56 , C07D213/64 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/08
Abstract: The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
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公开(公告)号：US20140088124A1
公开(公告)日：2014-03-27
申请号：US14123246
申请日：2012-06-01
Applicant: Robert J. DeVita , QingMei Hong , Zhong Lai , Kevin D. Dykstra , Yang Yu , Jian Liu , Donald M. Sperbeck , Tianying Jian , Deodial Guiadeen , Ginger Xu-qiang Yang , Zhicai Wu , Shuwen He , Pauline C. Ting , Robert Aslanian , Jeffrey T. Kuethe , James Balkovec , Rongze Kuang , Gang Zhou , Heping Wu
Inventor： Robert J. DeVita , QingMei Hong , Zhong Lai , Kevin D. Dykstra , Yang Yu , Jian Liu , Donald M. Sperbeck , Tianying Jian , Deodial Guiadeen , Ginger Xu-qiang Yang , Zhicai Wu , Shuwen He , Pauline C. Ting , Robert Aslanian , Jeffrey T. Kuethe , James Balkovec , Rongze Kuang , Gang Zhou , Heping Wu
IPC: C07D401/14 , C07D417/14 , C07D493/04 , C07D471/04
CPC classification number: C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04
Abstract: Described herein are compounds of formula (I), The compounds of formula I act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.
Abstract translation: 本文描述的是式（I）的化合物。式I化合物作为DGAT1抑制剂，可用于预防，治疗或作为高脂血症，糖尿病和肥胖症的补救剂。
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Patent Agency Ranking
公开(公告)号：US20070254901A1
公开(公告)日：2007-11-01
申请号：US11659606
申请日：2005-08-19
Applicant: Mark Bilodeau , Nicolas Cosford , John Hartnett , Yiwei Li , Jun Liang , Peter Manley , Lou Neilson , Tony Siu , Zhicai Wu
Inventor： Mark Bilodeau , Nicolas Cosford , John Hartnett , Yiwei Li , Jun Liang , Peter Manley , Lou Neilson , Tony Siu , Zhicai Wu
IPC: A61K31/519 , A61P35/00 , C07D471/04
CPC classification number: C07D471/04
Abstract: The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
Abstract translation: 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代的5-取代哌啶部分的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。
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公开(公告)号：US20130040929A1
公开(公告)日：2013-02-14
申请号：US13642646
申请日：2011-05-06
Applicant: Jeffrey J. Hale , Jinlong Jiang , Dong-Ming Shen , Zhi-Cai Shi , Min Shu , Zhicai Wu , Cangming Yang
Inventor： Jeffrey J. Hale , Jinlong Jiang , Dong-Ming Shen , Zhi-Cai Shi , Min Shu , Zhicai Wu , Cangming Yang
IPC: A61K31/506 , C07D401/04 , A61K31/454 , A61K31/4545 , A61P3/00 , C07D413/14 , A61K31/5377 , A61K31/4985 , A61P3/04 , A61P3/10 , C07D401/14 , A61K31/497
CPC classification number: C07D401/04 , C07D401/14
Abstract: Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
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18.发明申请SUBSTITUTED 1,2,4-OXADIAZOLES AND ANALOGS THEREOF AS CB2 RECEPTOR MODULATORS, USEFUL IN THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES 审中-公开作为CB2受体调节剂的替代的1,2,4-OXADIAZOLES及其类似物，有助于治疗疼痛，呼吸和非呼吸系统疾病公开(公告)号：US20100227845A1
公开(公告)日：2010-09-09
申请号：US12738192
申请日：2008-10-14
Applicant: Zhicai Wu , John C. Hartnett
Inventor： Zhicai Wu , John C. Hartnett
IPC: A61K31/4439 , C07D413/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P37/00 , C07D413/14 , A61K31/4545 , A61K31/496 , C07D417/14 , A61K31/541
CPC classification number: C07D413/04 , C07D401/04 , C07D413/14
Abstract: The present invention relates to compounds represented by Formula (I), Formula (II) and Formula (III) and pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical compositions comprising the instant compounds. This invention further provides methods to treat and prevent pain, respiratory and non-respiratory diseases.
Abstract translation: 本发明涉及由式（I），式（II）和式（III）表示的化合物及其药学上可接受的盐。 本发明还提供包含本发明化合物的药物组合物。 本发明还提供了治疗和预防疼痛，呼吸和非呼吸道疾病的方法。
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公开(公告)号：US20060030595A1
公开(公告)日：2006-02-09
申请号：US11188466
申请日：2005-07-25
Applicant: Mark Bilodeau , Christopher Dinsmore , Jeffrey Bergman , B. Trotter , Lou Neilson , Zhicai Wu , Peter Manley , John Hartnett
Inventor： Mark Bilodeau , Christopher Dinsmore , Jeffrey Bergman , B. Trotter , Lou Neilson , Zhicai Wu , Peter Manley , John Hartnett
IPC: A61K31/506 , A61K31/444 , C07D401/14 , C07D403/14
CPC classification number: C07D213/57 , C07D213/06 , C07D213/30 , C07D213/42 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D401/14 , C07D413/14 , C07D417/14
Abstract: The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
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公开(公告)号：US08933113B2
公开(公告)日：2015-01-13
申请号：US13979875
申请日：2012-01-19
Applicant: Alejandro Crespo , Ping Lan , Rudrajit Mal , Anthony Ogawa , Hong Shen , Peter J. Sinclair , Zhongxiang Sun , Ellen K. Vande Bunte , Zhicai Wu , Kun Liu , Robert J. DeVita , Dong-Ming Shen , Min Shu , John Qiang Tan , Changhe Qi , Yuguang Wang , Richard Beresis
Inventor： Alejandro Crespo , Ping Lan , Rudrajit Mal , Anthony Ogawa , Hong Shen , Peter J. Sinclair , Zhongxiang Sun , Ellen K. Vande Bunte , Zhicai Wu , Kun Liu , Robert J. DeVita , Dong-Ming Shen , Min Shu , John Qiang Tan , Changhe Qi , Yuguang Wang , Richard Beresis
IPC: A61K31/416 , C07D231/56 , A61K31/405 , A61K31/404 , C07D403/06 , C07D209/08 , C07D209/10 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K45/06 , C07D413/06
CPC classification number: C07D413/06 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/416 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K45/06 , C07D209/08 , C07D209/10 , C07D231/56 , C07D403/04 , C07D403/06 , C07D405/06
Abstract: Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and the pharmaceutical compositions which comprise compounds of the formula (I) are disclosed too.
Abstract translation: 公开了式（I）化合物及其药学上可接受的盐，其可用于治疗醛固酮介导的疾病。 还公开了制备式（I）化合物，用于治疗和预防上述疾病和用于制备用于此目的的药物的方法和包含式（I）化合物的药物组合物。
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