公开(公告)号：US08720270B2

公开(公告)日：2014-05-13

申请号：US13406519

申请日：2012-02-27

Applicant: Marc Stein ,  Andrew U. Chase ,  Philip Henson ,  Natalie Tran Burkhard ,  John Graham Keggi ,  Noah Byron Bonnheim

Inventor： Marc Stein ,  Andrew U. Chase ,  Philip Henson ,  Natalie Tran Burkhard ,  John Graham Keggi ,  Noah Byron Bonnheim

IPC: A61B5/22

CPC classification number: A61B8/0875 ,  A61B5/0082 ,  A61B5/01 ,  A61B5/1032 ,  A61B5/14539 ,  A61B5/4509 ,  A61B5/4528 ,  A61B5/4851 ,  A61B5/6846 ,  A61B8/58

Abstract: A prosthetic component suitable for long-term implantation is provided. The prosthetic component includes electronic circuitry and sensors to measure a parameter of the muscular-skeletal system. The prosthetic component comprises a first structure having at least one support surface, a second structure having at least one feature configured to couple to bone, and at least one sensor. The electronic circuitry and sensors are hermetically sealed within the prosthetic component. The prosthetic component includes at least on transmissive region. The transmissive region can be located in a region that has exposure to a region outside the joint. The transmissive region can comprise glass. One or more sensors can be used to monitor synovial fluid in proximity to the joint to determine joint health. The transmissive region can be used to support communication between the electronic circuitry and remote system.

Abstract translation: 提供了适合于长期植入的假体部件。 假肢部件包括用于测量肌肉骨骼系统的参数的电子电路和传感器。 假体部件包括具有至少一个支撑表面的第一结构，具有被配置为联接到骨骼的至少一个特征的第二结构以及至少一个传感器。 电子电路和传感器密封在假体部件内。 假体部件至少包括透射区域。 透射区域可以位于暴露于接头外部区域的区域中。 透射区域可以包括玻璃。 一个或多个传感器可用于监测靠近关节的滑液，以确定关节的健康状况。 透射区域可以用于支持电子电路和远程系统之间的通信。

公开(公告)号：US08701484B2

公开(公告)日：2014-04-22

申请号：US13406484

申请日：2012-02-27

Applicant: Marc Stein ,  Andrew U. Chase

Inventor： Marc Stein ,  Andrew U. Chase

IPC: A61B5/22

CPC classification number: A61B5/107 ,  A61B5/4509 ,  A61B5/4528 ,  A61B5/6846

Abstract: A measurement system for measuring a parameter of the muscular-skeletal system is disclosed. The measurement system comprises a capacitor, a signal generator, a digital counter, counter register, a digital clock, a digital timer, and a data register. The sensor of the measurement system is the capacitor. The measurement system generates a repeating signal having a measurement cycle that corresponds to the capacitance of the capacitor. The capacitor comprises more than one capacitor mechanically in series. Electrically, the capacitor comprises more than one capacitor in parallel. In one embodiment, the capacitor includes a dielectric layer comprising polyimide. A force, pressure, or load is applied to the capacitor that elastically compresses the device.

Abstract translation: 公开了一种用于测量肌肉骨骼系统参数的测量系统。 测量系统包括电容器，信号发生器，数字计数器，计数器寄存器，数字时钟，数字定时器和数据寄存器。 测量系统的传感器是电容器。 测量系统产生具有对应于电容器的电容的测量周期的重复信号。 电容器包括多个串联的电容器。 电气地，电容器包括多于一个并联的电容器。 在一个实施例中，电容器包括包含聚酰亚胺的电介质层。 力，压力或负载施加到弹性压缩装置的电容器上。

公开(公告)号：US20130079793A1

公开(公告)日：2013-03-28

申请号：US13243082

申请日：2011-09-23

Applicant: Marc Stein ,  Andrew U. Chase

Inventor： Marc Stein ,  Andrew U. Chase

IPC: A61B17/56

CPC classification number: A61F2/4657 ,  A61B5/45 ,  A61B5/4528 ,  A61B2034/2048 ,  A61B2090/064 ,  A61B2090/065 ,  A61F2/44 ,  A61F2/4684 ,  A61F2002/4666

Abstract: A measurement tool for measuring a parameter of the muscular-skeletal system is disclosed. The measurement tool includes a sensored head that comprises a first support structure, a second support structure, and a plurality of sensors for measuring load and position of load. The housing for the measurement tool includes a first housing component and a second housing component. The first housing component comprises a handle portion, a shaft portion, and a first support structure. Similarly, the second housing component comprises a handle portion, a shaft portion, and a second support structure. The sensored head includes an interconnect, a sensor guide, sensors, and a load plate. The interconnect and the sensor guide are aligned and retained in the first support structure by a sidewall.

Abstract translation: 公开了一种用于测量肌肉骨骼系统参数的测量工具。 测量工具包括感测头，其包括第一支撑结构，第二支撑结构和用于测量负载和负载位置的多个传感器。 用于测量工具的壳体包括第一壳体部件和第二壳体部件。 第一壳体部件包括手柄部分，轴部分和第一支撑结构。 类似地，第二壳体部件包括手柄部分，轴部分和第二支撑结构。 感应头包括互连，传感器引导件，传感器和负载板。 互连和传感器引导件通过侧壁对准并保持在第一支撑结构中。

公开(公告)号：US20130079673A1

公开(公告)日：2013-03-28

申请号：US13244219

申请日：2011-09-23

Applicant: Marc Stein ,  Andrew P. Miller ,  Jason Addink ,  Andrew U. Chase

Inventor： Marc Stein ,  Andrew P. Miller ,  Jason Addink ,  Andrew U. Chase

IPC: A61B5/103

CPC classification number: A61B5/4585 ,  A61B5/0031 ,  A61B5/11 ,  A61B5/686 ,  A61B5/6882 ,  A61B2560/0406 ,  A61B2562/24 ,  A61F2/4657 ,  A61F2/4684 ,  A61F2002/3895 ,  A61F2002/4666

Abstract: At least one embodiment is directed to an insert for measuring a parameter of the muscular-skeletal system. The insert can be temporary or permanent. In one embodiment, the insert is prosthetic component for a single compartment of the knee. The insert comprises a support structure and a support structure respectively having an articular surface and a load bearing surface. The height of the insert is less than 10 millimeters. At least one internal cavity is formed when support structures are coupled together for housing electronic circuitry, sensors, and the power source. The cavity is sterilized through a port. A membrane is between the port and the cavity. A sterilization gas permeates the membrane for sterilizing cavity. The membrane prevents ingress of solids and liquids to the cavity.

Abstract translation: 至少一个实施例涉及用于测量肌肉 - 骨骼系统的参数的插入件。 插入可以是临时的或永久的。 在一个实施例中，插入件是用于膝盖的单个隔室的假体部件。 插入件包括分别具有关节表面和承载表面的支撑结构和支撑结构。 刀片的高度小于10毫米。 当支撑结构耦合在一起以容纳电子电路，传感器和电源时，形成至少一个内部空腔。 腔通过端口消毒。 隔膜位于端口和腔体之间。 灭菌气体渗透膜用于消毒空腔。 膜防止固体和液体进入腔体。

公开(公告)号：US20130079672A1

公开(公告)日：2013-03-28

申请号：US13244211

申请日：2011-09-23

Applicant: Marc Stein ,  Andrew P. Miller ,  Jason Addink ,  Andrew U. Chase

Inventor： Marc Stein ,  Andrew P. Miller ,  Jason Addink ,  Andrew U. Chase

IPC: A61B5/103

CPC classification number: A61B5/6878 ,  A61B5/0031 ,  A61B5/1036 ,  A61B5/6882 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/4657 ,  A61F2002/30565 ,  A61F2002/30589 ,  A61F2002/30607 ,  A61F2002/30616 ,  A61F2002/30668 ,  A61F2002/3067 ,  A61F2002/30672 ,  A61F2002/30772 ,  A61F2002/3895 ,  A61F2002/4666

Abstract: At least one embodiment is directed to an insert for measuring a parameter of the muscular-skeletal system. The insert can be temporary or permanent. In one embodiment, the insert is prosthetic component for a single compartment of the knee. The insert comprises a support structure and a support structure respectively having an articular surface and a load bearing surface. The height of the insert can be less than 10 millimeters. At least one internal cavity is formed when support structures are coupled together for housing electronic circuitry, sensors, and the power source. The insert includes a flexible articular surface. Flexible articular surface transfers loading to sensors internal to the insert.

Abstract translation: 至少一个实施例涉及用于测量肌肉 - 骨骼系统的参数的插入件。 插入可以是临时的或永久的。 在一个实施例中，插入件是用于膝盖的单个隔室的假体部件。 插入件包括分别具有关节表面和承载表面的支撑结构和支撑结构。 刀片的高度可以小于10毫米。 当支撑结构耦合在一起以容纳电子电路，传感器和电源时，形成至少一个内部空腔。 插入物包括柔性关节表面。 弹性关节表面传递加载到插入物内部的传感器。

公开(公告)号：US08337428B2

公开(公告)日：2012-12-25

申请号：US12826134

申请日：2010-06-29

Applicant: Marc Stein ,  Andrew Kelly

Inventor： Marc Stein ,  Andrew Kelly

IPC: A61B5/103 ,  A61B17/56

CPC classification number: A61B5/6878 ,  A61B5/4509 ,  A61B5/4528 ,  A61B5/6846 ,  A61B5/7239 ,  A61B8/15 ,  Y10T307/615

Abstract: A sensor system uses positive closed-loop feedback to provide energy waves into a medium. It comprises a transducer (604), a propagating structure (602), and a transducer (606). A parameter is applied to the propagating structure that affects the medium. A sensor is coupled to a propagation tuned oscillator (416) that forms a positive closed-loop feedback path. The propagation tuned oscillator (416) includes a zero-crossing receiver (200) that generates a pulse upon sensing a transition of an energy wave from the propagating structure (602). The zero-crossing receiver (200) is in the feedback path that maintains the emission of energy waves into the propagating structure (602). The zero-crossing receiver (200) comprises a preamplifier (206), a filter (208), an offset adjustment circuit (210), a comparator (212) and a pulse circuit (218). The transit time, phase, or frequency is measured of the propagating energy waves and correlated to the parameter being measured.

Abstract translation: 传感器系统使用正闭环反馈来向介质提供能量波。 它包括换能器（604），传播结构（602）和换能器（606）。 将参数应用于影响介质的传播结构。 传感器耦合到形成正闭环反馈路径的传播调谐振荡器（416）。 传播调谐振荡器（416）包括过零接收器（200），其在感测到来自传播结构（602）的能量波的转变时产生脉冲。 过零接收器（200）处于将能量波发射到传播结构（602）中的反馈路径中。 过零接收器（200）包括前置放大器（206），滤波器（208），偏移调整电路（210），比较器（212）和脉冲电路（218）。 传播时间，相位或频率是测量传播的能量波，并与所测量的参数相关。

公开(公告)号：US20120190940A1

公开(公告)日：2012-07-26

申请号：US13406525

申请日：2012-02-27

Applicant: Marc Stein ,  Andrew Chase

Inventor： Marc Stein ,  Andrew Chase

IPC: A61B5/01 ,  A61B5/00

CPC classification number: A61B5/4851 ,  A61B5/0008 ,  A61B5/0022 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/4509 ,  A61B5/4528 ,  A61B5/6846

Abstract: A prosthetic component suitable for long-term implantation is provided. The prosthetic component includes electronic circuitry and sensors to measure a parameter of the muscular-skeletal system. The prosthetic component comprises a first structure having at least one support surface, a second structure having at least one feature configured to couple to bone. The electronic circuitry and sensors are hermetically sealed within the prosthetic component. Sensors can be used to monitor synovial fluid in proximity to the joint to determine joint health. The prosthetic component can include a temperature sensor or a pH sensor. The temperature or pH of the synovial fluid can be correlated to a variety of joint conditions. Measurements over time can be analyzed for trends. The temperature or pH can be calibrated for the patient. For example, calibration can be for temperature or pH of a patient healthy joint. The measurements are compared against this patient reference.

Abstract translation: 提供了适合于长期植入的假体部件。 假肢部件包括用于测量肌肉骨骼系统的参数的电子电路和传感器。 假体部件包括具有至少一个支撑表面的第一结构，具有被配置为联接到骨的至少一个特征的第二结构。 电子电路和传感器密封在假体部件内。 传感器可用于监测靠近关节的滑液，以确定关节的健康状况。 假体部件可以包括温度传感器或pH传感器。 滑液的温度或pH可以与各种关节条件相关。 随着时间的推移可以分析趋势。 可以为患者校准温度或pH。 例如，校准可以用于患者健康关节的温度或pH。 将测量值与该患者参考值进行比较。

公开(公告)号：US20120152036A1

公开(公告)日：2012-06-21

申请号：US13406510

申请日：2012-02-27

Applicant: Marc Stein ,  Andrew Chase

Inventor： Marc Stein ,  Andrew Chase

IPC: G01L1/14

CPC classification number: A61F2/4657 ,  A61B5/076 ,  A61B5/4509 ,  A61B5/4528 ,  A61B5/6846 ,  A61B5/6847 ,  A61B17/1615 ,  A61B17/1666 ,  A61B2090/065 ,  A61B2562/0252 ,  A61B2562/182

Abstract: A measurement system for measuring a parameter of the muscular-skeletal system is disclosed. The measurement system comprises a capacitor, a signal generator, a digital counter, counter register, a digital clock, a digital timer, and a data register. The sensor of the measurement system is the capacitor. The measurement system generates a repeating signal having a measurement cycle that corresponds to the capacitance of the capacitor. The capacitor comprises more than one capacitor mechanically in series. Electrically, the capacitor comprises more than one capacitor in parallel. In one embodiment, the capacitor includes a dielectric layer comprising polyimide. A force, pressure, or load is applied to the capacitor that elastically compresses the device. The capacitor is shielded from parasitic coupling and parasitic capacitance.

Abstract translation: 公开了一种用于测量肌肉骨骼系统参数的测量系统。 测量系统包括电容器，信号发生器，数字计数器，计数器寄存器，数字时钟，数字计时器和数据寄存器。 测量系统的传感器是电容器。 测量系统产生具有对应于电容器的电容的测量周期的重复信号。 电容器包括多个串联的电容器。 电气地，电容器包括多于一个并联的电容器。 在一个实施例中，电容器包括包含聚酰亚胺的电介质层。 力，压力或负载施加到弹性压缩装置的电容器上。 电容器屏蔽寄生耦合和寄生电容。

公开(公告)号：US20100331687A1

公开(公告)日：2010-12-30

申请号：US12826247

申请日：2010-06-29

Applicant: Marc Stein ,  Andrew Kelly

Inventor： Marc Stein ,  Andrew Kelly

IPC: A61B8/00 ,  G01S7/493

CPC classification number: A61B5/6878 ,  A61B5/4509 ,  A61B5/4528 ,  A61B5/6846 ,  A61B5/7239 ,  A61B8/15 ,  Y10T307/615

Abstract: A measurement system for capturing a transit time, phase, or frequency of energy waves propagating through a propagation medium is disclosed. The measurement system comprises two different closed-loop feedback paths. The first path includes a driver circuit (628), a transducer (604), a propagation medium (602), a transducer (606), and a zero-crossing receiver (640). The zero-crossing receiver (640) detects transition states of propagated energy waves in the propagation medium including the transition of each energy wave through a mid-point of a symmetrical or cyclical waveform. A second path includes the driver circuit (1228), a transducer (1204), a propagation medium (1202), a reflecting surface (1206), and an edge-detect receiver (1240). Energy waves in the propagating medium (1202) are reflected at least once. The edge-detect receiver (1240) detects a wave front of an energy wave. Each positive closed-loop path maintains the emission, propagation, and detection of energy waves in the propagation medium.

Abstract translation: 公开了一种用于捕获通过传播介质传播的能量波的传播时间，相位或频率的测量系统。 测量系统包括两个不同的闭环反馈路径。 第一路径包括驱动器电路（628），换能器（604），传播介质（602），换能器（606）和过零接收器（640）。 过零接收器（640）检测传播介质中传播的能量波的转变状态，包括每个能量波通过对称或循环波形的中点的转变。 第二路径包括驱动器电路（1228），换能器（1204），传播介质（1202），反射表面（1206）和边缘检测接收器（1240）。 传播介质（1202）中的能量波反射至少一次。 边缘检测接收器（1240）检测能量波的波前。 每个正闭环路径保持传播介质中能量波的发射，传播和检测。

公开(公告)号：US20100331685A1

公开(公告)日：2010-12-30

申请号：US12826109

申请日：2010-06-29

Applicant: Marc Stein ,  Andrew Kelly

Inventor： Marc Stein ,  Andrew Kelly

IPC: A61B8/00

CPC classification number: A61B5/6878 ,  A61B5/4509 ,  A61B5/4528 ,  A61B5/6846 ,  A61B5/7239 ,  A61B8/15 ,  Y10T307/615

Abstract: A measurement system for capturing a transit time, phase, or frequency of energy waves propagating through a propagation medium is disclosed. The measurement system comprises two different closed-loop feedback paths. The first path includes a transducer driver (726), a transducer (704), a propagation structure (702), a transducer (706), and a zero-crossing receiver (740). The transducer driver (726) efficiently drives the transducer (704) and comprises a digital driver (106), a level shifter (112), and a matching network (114). A second path includes a transducer driver (1126), a transducer (1104), a propagation medium (1102), a reflecting surface (1106), and an edge-detect receiver (1140). Energy waves in the propagating medium (1102) are reflected at least once. The edge-detect receiver (1140) detects a wave front of an energy wave. Each positive closed-loop path maintains the emission, propagation, and detection of energy waves in the propagation medium.

Abstract translation: 公开了一种用于捕获通过传播介质传播的能量波的传播时间，相位或频率的测量系统。 测量系统包括两个不同的闭环反馈路径。 第一路径包括换能器驱动器（726），换能器（704），传播结构（702），换能器（706）和过零接收器（740）。 换能器驱动器（726）有效地驱动换能器（704）并且包括数字驱动器（106），电平转换器（112）和匹配网络（114）。 第二路径包括换能器驱动器（1126），换能器（1104），传播介质（1102），反射表面（1106）和边缘检测接收器（1140）。 传播介质（1102）中的能量波反射至少一次。 边缘检测接收器（1140）检测能量波的波前。 每个正闭环路径保持传播介质中能量波的发射，传播和检测。