公开(公告)号：US10508138B2

公开(公告)日：2019-12-17

申请号：US15737937

申请日：2015-09-16

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Hak-Sung Kim ,  Da Eun Hwang ,  Jeong Hyun Ryou

IPC: C07K14/00 ,  C07K14/475 ,  A61K38/16 ,  C07K14/46 ,  A61P27/02 ,  A61P35/00 ,  A61K38/00

Abstract: The present disclosure relates to a novel polypeptide capable of binding specifically to vascular endothelial growth factor, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a recombinant microorganism including the expression vector, a method of producing the polypeptide using the recombinant microorganism, a composition for treating or preventing age-related macular degeneration or cancer, which comprises the polypeptide, and a method for preventing or treating age-related macular degeneration or cancer, which comprises administering the composition for treating or preventing age-related macular degeneration or cancer, which comprises the polypeptide. The disclosed polypeptide is capable of binding to vascular endothelial growth factor to inhibit the activity thereof, and thus can be widely used as an agent for treating and preventing various diseases associated with vascular endothelial growth factor (VEGF).

公开(公告)号：US20180170980A1

公开(公告)日：2018-06-21

申请号：US15737937

申请日：2015-09-16

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Hak-Sung Kim ,  Da Eun Hwang ,  Jeong Hyun Ryou

IPC: C07K14/46 ,  A61P35/00 ,  A61P27/02

CPC classification number: C07K14/461 ,  A61K38/00 ,  A61P27/02 ,  A61P35/00 ,  C07K14/195 ,  C07K14/52 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/70

Abstract: The present disclosure relates to a novel polypeptide capable of binding specifically to vascular endothelial growth factor, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a recombinant microorganism including the expression vector, a method of producing the polypeptide using the recombinant microorganism, a composition for treating or preventing cancer, which comprises the polypeptide, and a method for preventing or treating cancer, which comprises administering the composition for treating or preventing cancer, which comprises the polypeptide. The disclosed polypeptide is capable of binding to vascular endothelial growth factor to inhibit the activity thereof, and thus can be widely used as an agent for treating and preventing various diseases associated with vascular endothelial growth factor (VEGF).

公开(公告)号：US09777046B2

公开(公告)日：2017-10-03

申请号：US14322864

申请日：2014-07-02

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Hak-Sung Kim ,  Woosung Heu ,  Joong-Jae Lee ,  Seong-Min Jo

IPC: C07K14/195 ,  C07K14/705 ,  C07K16/06

CPC classification number: C07K14/195 ,  C07K14/705 ,  C07K16/065 ,  C07K2319/70

Abstract: The present invention relates to a polypeptide (repebody) selectively bound to an immunoglobulin G, a polynucleotide which encodes the repebody, a vector containing the polynucleotide, a recombinant microorganism in which the polynucleotide is introduced, a method for producing the repebody using the recombinant microorganism, and a method for immobilizing or purifying an immunoglobulin G using the repebody. The repebody according to the present invention is useful as utilized for immobilization of an immunoglobulin G, purification of an immunoglobulin G, and production of an immunosensor, since the repebody selectively bound to an immunoglobulin G.