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公开(公告)号:US20140288076A1
公开(公告)日:2014-09-25
申请号:US14295398
申请日:2014-06-04
Applicant: Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
Inventor: Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC: C07D409/14 , C07D401/14 , C07D405/14 , C07D401/04
CPC classification number: A61K31/497 , C07D213/74 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
Abstract: The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
Abstract translation: 本发明提供式(I)化合物及其药学上可接受的盐,对映体,立体异构体,旋转异构体,互变异构体,非对映体或其外消旋物。 还提供了治疗由CDK9介导的疾病或病症的方法。
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12.
公开(公告)号:US08293769B2
公开(公告)日:2012-10-23
申请号:US12451326
申请日:2008-05-20
Applicant: Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton , Allan S. Wagman , Marion Wiesmann
Inventor: Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton , Allan S. Wagman , Marion Wiesmann
IPC: A61K31/5377 , A61K31/519 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4745 , A61K31/4545 , A61K31/454 , A61K31/444 , A61K31/4439 , C07D495/04 , C07D487/04 , C07D417/12 , C07D417/14 , C07D413/12 , C07D413/14
CPC classification number: C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
Abstract: Benzoxazole and benzothiazole compounds and their oxides, esters, prodrugs, solvates, and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF 1R.
Abstract translation: 公开了苯并恶唑和苯并噻唑化合物及其氧化物,酯,前药,溶剂合物及其药学上可接受的盐。 还公开了单独或与至少一种另外的治疗剂组合的化合物与药学上可接受的载体的组合,以及化合物单独或与至少一种另外的治疗剂组合的用途。 这些实施方案可用于抑制细胞增殖,抑制肿瘤的生长和/或复分解,治疗或预防癌症,治疗或预防退行性骨疾病如类风湿性关节炎和/或抑制分子如CSF 1R。
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公开(公告)号:US08173657B2
公开(公告)日:2012-05-08
申请号:US12294233
申请日:2007-03-23
Applicant: James Sutton , Feng Xu , Nicholas Valiante , Jiong Lan
Inventor: James Sutton , Feng Xu , Nicholas Valiante , Jiong Lan
IPC: A61K31/50 , A61K39/02 , A61K39/12 , A61K39/00 , C07D471/00 , C07D487/00
CPC classification number: A61K31/4985 , A61K39/21 , A61K39/39 , C07D487/04
Abstract: The invention provides novel compositions comprising imidazoquinoxaline compounds of formula (I) and analogs thereof. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of administering the compositions in combination with (an) other agent(s).
Abstract translation: 本发明提供了包含式(I)的咪唑并喹喔啉化合物及其类似物的新型组合物。 还提供了以有效量施用组合物以增强受试者的免疫应答的方法。 进一步提供了组合物与(一种或多种)其它试剂组合施用的新组合物和方法。
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14.
公开(公告)号:US20100261679A1
公开(公告)日:2010-10-14
申请号:US12738277
申请日:2008-10-16
Applicant: James Sutton , Martin Sendzik , Weibo Wang
Inventor: James Sutton , Martin Sendzik , Weibo Wang
IPC: A61K31/66 , C12N5/071 , A61K31/4709 , A61K31/517 , A61K31/5377 , A61K31/4439 , C07D215/38 , C07D401/12 , C07D413/12 , C07D417/10 , A61P35/00
CPC classification number: A61K31/4184 , A61K31/4188 , A61K31/428 , A61K31/429 , A61K31/47 , A61K31/517
Abstract: Disclosed herein are compounds and their oxides, esters, prodrugs, solvates, and pharmaceutically acceptable salts thereof, compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.
Abstract translation: 本文公开了化合物及其氧化物,酯,前药,溶剂化物和药学上可接受的盐,化合物的组合物,单独或与至少一种另外的治疗剂组合与药学上可接受的载体,以及该化合物的用途, 单独或与至少一种另外的治疗剂组合。 这些实施方案可用于抑制细胞增殖,抑制肿瘤的生长和/或复分解,治疗或预防癌症,治疗或预防退行性骨疾病如类风湿性关节炎和/或抑制分子如CSF-1R。
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公开(公告)号:US20090232844A1
公开(公告)日:2009-09-17
申请号:US12294237
申请日:2007-03-23
Applicant: James Sutton , Nicholas Valiante
Inventor: James Sutton , Nicholas Valiante
IPC: A61K39/145 , C07D471/04 , A61K31/437 , A61K31/4375 , C07D471/14 , A61P31/12 , A61P31/04 , A61K39/00 , A61K39/02 , A61K39/12
CPC classification number: C07D471/14 , C07D471/04
Abstract: The invention provides novel compositions comprising Imidazopyridine compounds. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of administering the compositions in combination with (an)other agent(s).
Abstract translation: 本发明提供包含咪唑并吡啶化合物的新型组合物。 还提供了以有效量施用组合物以增强受试者的免疫应答的方法。 进一步提供了组合物与(一种或多种)其它试剂组合施用的新组合物和方法。
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公开(公告)号:US20080109638A1
公开(公告)日:2008-05-08
申请号:US12005570
申请日:2007-12-27
Applicant: John Wilson , Ioannis Schoinas , Mazin Yousif , Linda Rankin , David Grawrock , Robert Greiner , James Sutton , Kushagra Vaid , Willard Wiseman
Inventor: John Wilson , Ioannis Schoinas , Mazin Yousif , Linda Rankin , David Grawrock , Robert Greiner , James Sutton , Kushagra Vaid , Willard Wiseman
IPC: G06F9/06
CPC classification number: G06F21/575 , G06F21/44 , G06F21/445 , G06F21/50 , G06F21/606 , G06F21/64 , G06F21/71 , G06F2221/034
Abstract: In one embodiment of the present invention, a method includes verifying an initiating logical processor of a system; validating a trusted agent with the initiating logical processor if the initiating logical processor is verified; and launching the trusted agent on a plurality of processors of the system if the trusted agent is validated. After execution of such a trusted agent, a secure kernel may then be launched, in certain embodiments. The system may be a multiprocessor server system having a partially or fully connected topology with arbitrary point-to-point interconnects, for example.
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公开(公告)号:US20080109636A1
公开(公告)日:2008-05-08
申请号:US12005450
申请日:2007-12-27
Applicant: John Wilson , Ioannis Schoinas , Mazin Yousif , Linda Rankin , David Grawrock , Robert Greiner , James Sutton , Kushagra Vaid , Willard Wiseman
Inventor: John Wilson , Ioannis Schoinas , Mazin Yousif , Linda Rankin , David Grawrock , Robert Greiner , James Sutton , Kushagra Vaid , Willard Wiseman
IPC: G06F9/06
CPC classification number: G06F21/575 , G06F21/44 , G06F21/445 , G06F21/50 , G06F21/606 , G06F21/64 , G06F21/71 , G06F2221/034
Abstract: In one embodiment of the present invention, a method includes verifying an initiating logical processor of a system; validating a trusted agent with the initiating logical processor if the initiating logical processor is verified; and launching the trusted agent on a plurality of processors of the system if the trusted agent is validated. After execution of such a trusted agent, a secure kernel may then be launched, in certain embodiments. The system may be a multiprocessor server system having a partially or fully connected topology with arbitrary point-to-point interconnects, for example.
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公开(公告)号:US20060206943A1
公开(公告)日:2006-09-14
申请号:US11386269
申请日:2006-03-21
Applicant: Carl Ellison , Roger Golliver , Howard Herbert , Derrick Lin , Francis McKeen , Gilbert Neiger , Ken Reneris , James Sutton , Shreekant Thakkar , Millind Mittal
Inventor: Carl Ellison , Roger Golliver , Howard Herbert , Derrick Lin , Francis McKeen , Gilbert Neiger , Ken Reneris , James Sutton , Shreekant Thakkar , Millind Mittal
IPC: H04N7/16
CPC classification number: G06F21/53 , G06F9/468 , G06F21/562 , G06F21/57 , G06F21/74 , G06F2221/2105
Abstract: A processing system has a processor that can operate in a normal ring 0 operating mode and one or more higher ring operating modes above the normal ring 0 operating mode. In addition, the processor can operate in an isolated execution mode. A memory in the processing system may include an ordinary memory area that can be accessed from the normal ring 0 operating mode, as well as an isolated memory area that can be accessed from the isolated execution mode but not from the normal ring 0 operating mode. The processing system may also include an operating system (OS) nub, as well as a key generator. The key generator may generate an OS nub key (OSNK) based at least in part on an identification of the OS nub and a master binding key (BK0) of the platform. Other embodiments are described and claimed.
Abstract translation: 处理系统具有处理器,该处理器可以在正常环0操作模式和高于正常环0操作模式的一个或多个较高环操作模式下操作。 此外,处理器可以在隔离的执行模式下操作。 处理系统中的存储器可以包括可以从正常环0操作模式访问的普通存储器区域以及可以从隔离执行模式而不是从正常环0操作模式访问的隔离存储器区域。 处理系统还可以包括操作系统(OS)nub以及密钥生成器。 密钥生成器可以至少部分地基于OS nub的标识和平台的主绑定密钥(BK 0)来生成OS nub密钥(OSNK)。 描述和要求保护其他实施例。
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公开(公告)号:US20060199123A1
公开(公告)日:2006-09-07
申请号:US11063602
申请日:2005-02-24
Applicant: Michel Seguin , James Sutton , Rebecca Tobiasz , Matthew Odinotski
Inventor: Michel Seguin , James Sutton , Rebecca Tobiasz , Matthew Odinotski
IPC: F23N5/00
CPC classification number: F23N5/082 , F23N2029/08 , G01N21/72
Abstract: Techniques for determining a characteristic of a flame are provided by the present invention. Provided are methods as well as devices. A flame is monitored across a contiguous spectral range to detect light emitted by the monitored flame. The contiguous spectral range is segmented into a plurality of discrete ranges, and detected light across each of the one or more of the plurality of discrete ranges is respectively processed to determine at least one characteristic of the flame.
Abstract translation: 用于确定火焰特性的技术由本发明提供。 提供的方法和设备。 在连续的光谱范围内监视火焰以检测被监视的火焰发射的光。 连续的光谱范围被分割成多个离散的范围,并且分别处理多个离散范围中的一个或多个离散范围中的每一个上的检测光以确定火焰的至少一个特征。
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公开(公告)号:US20060080528A1
公开(公告)日:2006-04-13
申请号:US11289747
申请日:2005-11-29
Applicant: Carl Ellison , James Sutton
Inventor: Carl Ellison , James Sutton
IPC: H04L9/00
CPC classification number: H04L9/3265 , H04L9/3271 , H04L2209/42
Abstract: In one embodiment, a method for utilizing a pseudonym to protect the identity of a platform and its user is described. The method comprises producing a pseudonym that includes a public pseudonym key. The public pseudonym key is placed in a certificate template. Hash operations are performed on the certificate template to produce a certificate hash value, which is transformed from the platform. Thereafter, a signed result is returned to the platform. The signed result is a digital signature for the transformed certificate hash value. Upon performing an inverse transformation of the signed result, a digital signature of the certificate hash value is recovered. This digital signature may be used for data integrity checks for subsequent communications using the pseudonym.
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