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公开(公告)号：US12005437B2
公开(公告)日：2024-06-11
申请号：US16884852
申请日：2020-05-27
申请人： Illumina, Inc.
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01L2200/16 , B01L2300/042 , B01L2300/044 , B01L2300/047 , B01L2300/14 , B01L2400/0475 , B01L2400/06
摘要： Two-phase flushing systems and methods. An example method includes moving a valve to a first position to fluidly connect a first reagent reservoir containing a first reagent to a flow cell and flowing the first reagent from the first reagent reservoir to the flow cell to perform a biochemical reaction. The method includes moving the valve to a second position to fluidly connect a gas to the flow cell and flowing gas into the flow cell to expel at least a portion of the first reagent from the biochemical reaction from the flow cell. The method includes moving the valve to a third position to fluidly connect a buffer reagent reservoir containing a buffer reagent to the flow cell and flowing the buffer reagent into the flow cell.
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公开(公告)号：US20230330671A1
公开(公告)日：2023-10-19
申请号：US18215794
申请日：2023-06-28
申请人： ILLUMINA, INC.
发明人： Sz-chin Steven Lin , Richard Lemoine , Rajagopal Panchapakesan , Wesley A. Cox-Muranami , Darren Segale
CPC分类号： B01L3/502738 , G01M3/26 , F16K99/0028 , G01M3/2876 , F16K99/0013 , F16K2099/0084 , B01L2400/0644
摘要： A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.
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公开(公告)号：US20220280940A1
公开(公告)日：2022-09-08
申请号：US17750610
申请日：2022-05-23
申请人： ILLUMINA, INC.
发明人： Sz-Chin Steven Lin , Richard Lemoine , Rajagopal Panchapakesan , Wesley A. Cox-Muranami , Darren Segale
摘要： A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.
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公开(公告)号：US11351541B2
公开(公告)日：2022-06-07
申请号：US16500787
申请日：2018-04-02
申请人： ILLUMINA, INC.
发明人： Sz-Chin Steven Lin , Richard Lemoine , Rajagopal Panchapakesan , Wesley A. Cox-Muranami , Darren Segale
摘要： A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.
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公开(公告)号：US12011713B2
公开(公告)日：2024-06-18
申请号：US17817204
申请日：2022-08-03
申请人： Illumina, Inc.
发明人： Wesley A. Cox-Muranami , Kay Klausing , Bradley Kent Drews , Nicholas Watson , Jennifer Olivia Foley , Murphy Hitchcock , Paul Sangiorgio , Sz-Chin Steven Lin
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01L2200/141 , B01L2200/16 , B01L2300/047 , B01L2300/06 , B01L2400/0487 , B01L2400/0644
摘要： A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.
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公开(公告)号：US11724258B2
公开(公告)日：2023-08-15
申请号：US17750610
申请日：2022-05-23
申请人： ILLUMINA, INC.
发明人： Sz-Chin Steven Lin , Richard Lemoine , Rajagopal Panchapakesan , Wesley A. Cox-Muranami , Darren Segale
CPC分类号： B01L3/502738 , F16K99/0013 , F16K99/0028 , G01M3/26 , G01M3/2876 , B01L2400/0644 , F16K2099/0084
摘要： A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.
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公开(公告)号：US11372016B2
公开(公告)日：2022-06-28
申请号：US16584306
申请日：2019-09-26
申请人： Illumina, Inc.
IPC分类号： G01N35/10
摘要： An apparatus includes a fluidic circuit, a bypass fluidic circuit, a first set of fluid wells, a second set of fluid wells, a first valve, and a second valve. The first valve operatively associated with the first set of fluid wells such that the first selectively fluidly connects any one of the first set of fluid wells to a first valve outlet. The second valve operatively associated with the fluidic circuit, the bypass fluidic circuit, the first valve outlet, and the second set of fluid wells such that the second valve selectively fluidly connects any one of the second set of fluid wells and the first valve outlet to the fluidic circuit or the first valve outlet to the bypass fluidic circuit.
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18.发明申请公开(公告)号：US20210276241A1
公开(公告)日：2021-09-09
申请号：US17250276
申请日：2020-01-15
申请人： Illumina, Inc.
摘要： Laminated microfluidic structures and methods for manufacturing the same are provided. In some instances, a laminated microfluidic structure is provided which includes a distended region having a sipper port at the bottom and an internal channel that fluidically connects the sipper port to a location outside of the distended region. Thermoforming and/or injection molding techniques for manufacturing such laminated microfluidic structures are provided. In other instances, a laminated microfluidic structure may be co-molded with a polymeric material to produce an integrated laminated microfluidic structure and housing.
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