公开(公告)号：US20160106949A1

公开(公告)日：2016-04-21

申请号：US14886556

申请日：2015-10-19

Applicant: INO Therapeutics LLC

Inventor： Thomas Kohlmann ,  John Klaus

IPC: A61M16/20

Abstract: Described are systems and methods for providing a pulse of a therapeutic gas with a desired flow profile to maximize therapeutic effectiveness. Systems and methods of the present disclosure can generate and/or provide desired flow profiles with various shapes and/or properties by configuring, modifying, optimizing, and/or factoring in aspects of at least one fixed flow rate assembly of a therapeutic gas delivery system such as, but not limited to, spatial relationships of elements of the fixed flow rate assembly, rate of valve closure and opening, latent flows, transient wave generation and/or propagation, to name a few.

Abstract translation: 描述了用于提供具有期望流动分布的治疗气体的脉冲以最大化治疗有效性的系统和方法。 本公开的系统和方法可以通过在治疗气体输送系统的至少一个固定流速组件的方面进行配置，修改，优化和/或分解来产生和/或提供具有各种形状和/或性质的所需流量分布 例如但不限于固定流量组件的元件，阀闭合和打开速率，潜在流量，瞬态波产生和/或传播的空间关系，仅举几个例子。

公开(公告)号：US20140261415A1

公开(公告)日：2014-09-18

申请号：US14218067

申请日：2014-03-18

Applicant: INO Therapeutics LLC

Inventor： Jaron Acker ,  Thomas Kohlmann ,  Craig R. Tolmie

IPC: A61M16/20 ,  A61M16/04 ,  A61M16/00 ,  A61M16/06 ,  A61M16/12 ,  A61M16/10

CPC classification number: A61M16/12 ,  A61M16/024 ,  A61M16/0677 ,  A61M16/202 ,  A61M16/203 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/0039 ,  A61M2202/0275 ,  A61M2205/3334 ,  A61M2205/502

Abstract: Described are methods and devices for therapeutic or medical gas delivery that utilize at least one proportional control valve and at least one binary control valve. The proportional control valve may be in series with the binary control valve to provide a valve combination capable of pulsing therapeutic gas at different flow rates, depending on the setting of the proportional control valve. Alternatively, the proportional control valve and binary control valve may be in parallel flow paths.

Abstract translation: 描述了利用至少一个比例控制阀和至少一个二进制控制阀的治疗或医用气体输送的方法和装置。 比例控制阀可以与二进制控制阀串联，以提供能够根据比例控制阀的设定以不同流量脉冲治疗气体的阀组合。 或者，比例控制阀和二进制控制阀可以是并联的流动路径。

公开(公告)号：US08770199B2

公开(公告)日：2014-07-08

申请号：US14096629

申请日：2013-12-04

Applicant: INO Therapeutics LLC

Inventor： Craig Flanagan ,  Simon Freed ,  John Klaus ,  Thomas Kohlmann ,  Martin D. Meglasson ,  Manesh Naidu ,  Parag Shah

IPC: A61M15/08 ,  A62B7/00 ,  A61M15/00 ,  A61M16/10 ,  A61M16/00 ,  A61M16/06 ,  A61M16/12 ,  A61M16/20

CPC classification number: A61M16/0672 ,  A61M16/009 ,  A61M16/0666 ,  A61M16/0677 ,  A61M16/0875 ,  A61M16/10 ,  A61M16/1005 ,  A61M16/101 ,  A61M16/104 ,  A61M16/12 ,  A61M16/122 ,  A61M16/125 ,  A61M16/204 ,  A61M16/208 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2202/0208 ,  A61M2202/0266 ,  A61M2202/0275 ,  A61M2202/0283 ,  A61M2205/0216 ,  A61M2205/3303 ,  A61M2205/3331 ,  A61M2205/75 ,  A61M2210/0618

Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.

Abstract translation: 本发明通常涉及通过例如减少吸入的一氧化氮（NO）的稀释度来提供一氧化氮治疗的精度和/或精度的系统，装置，材料和方法。 如本文所述，由于各种因素，可能会发生NO稀释。 为了减少预期的NO剂量的稀释，公开了各种示例性鼻插管，气动构造，制造方法和使用方法等。

公开(公告)号：US20140166009A1

公开(公告)日：2014-06-19

申请号：US14096548

申请日：2013-12-04

Applicant: INO Therapeutics LLC

Inventor： Craig Flanagan ,  Simon Freed ,  John Klaus ,  Thomas Kohlmann ,  Martin D. Meglasson ,  Manesh Naidu ,  Parag Shah

IPC: A61M16/06 ,  A61M16/20 ,  A61M16/00 ,  A61M16/12 ,  A61M16/10

CPC classification number: A61M16/0677 ,  A61M16/06 ,  A61M16/0666 ,  A61M16/0672 ,  A61M16/0858 ,  A61M16/208 ,  A61M2202/0208 ,  A61M2202/0275 ,  A61M2206/10 ,  A61M2207/00

Abstract: Described are nasal cannulas that improve the precision of the delivered dose for nitric oxide therapy by reducing the dilution of nitric oxide. The nasal cannulas may reduce the total volume and potential for retrograde flow during nitric oxide therapy through the design of the specific dimensions of the flow path and/or having check valves in the nitric oxide delivery line and/or having a flapper or umbrella valve dedicated to nitric oxide delivery. The nasal cannulas may also use materials that limit oxygen diffusion through the cannula walls. The nosepiece for these cannulas may be manufactured by a molding technique.

Abstract translation: 描述了通过减少一氧化氮的稀释来改善一氧化氮治疗的递送剂量的精确度的鼻插管。 鼻塞可以通过设计流路的具体尺寸和/或在一氧化氮输送管线中具有止回阀和/或具有专门的挡板或伞形阀来减少一氧化氮治疗期间的逆行流量的总体积和潜力 一氧化氮输送。 鼻插管还可以使用限制通过插管壁的氧扩散的材料。 这些插管的鼻梁可以通过模制技术制造。