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公开(公告)号：US20200171002A1
公开(公告)日：2020-06-04
申请号：US16512823
申请日：2019-07-16
Applicant: Array BioPharma Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: A61K31/4184 , A61K45/06 , A61K9/20 , A61K9/00 , C07D235/08 , A61K47/12 , A61K47/02 , C30B29/54 , C30B7/08 , C07D235/06 , A61K47/38 , A61K47/26
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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公开(公告)号：US20180296533A1
公开(公告)日：2018-10-18
申请号：US15842715
申请日：2017-12-14
Applicant: Array BioPharma Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: A61K31/4184 , A61K45/06 , A61K47/26 , A61K9/20 , A61K9/00 , C07D235/08 , C07D235/06 , A61K47/12 , A61K47/02 , C30B29/54 , C30B7/08 , A61K47/38
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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公开(公告)号：US09562016B2
公开(公告)日：2017-02-07
申请号：US14974655
申请日：2015-12-18
Applicant: Novartis AG , Array BioPharma, Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: C07D235/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , A61K9/20 , C30B7/08 , C30B29/54 , C07D235/08
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Abstract translation: 本发明涉及制备6-（4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺的方法， （4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺，以及有用的中间体。 本文还提供包含该结晶化合物的药物组合物。
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公开(公告)号：US20140128442A1
公开(公告)日：2014-05-08
申请号：US14057498
申请日：2013-10-18
Applicant: Array BioPharma, Inc. , Novartis AG
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: C07D235/06 , A61K47/38 , A61K47/26
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Abstract translation: 本发明涉及制备6-（4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺的方法， （4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺，以及有用的中间体。 本文还提供包含该结晶化合物的药物组合物。
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公开(公告)号：US10398683B2
公开(公告)日：2019-09-03
申请号：US15842715
申请日：2017-12-14
Applicant: Array BioPharma Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: A61K31/4184 , A61K45/06 , A61K47/26 , A61K9/20 , C07D235/08 , C07D235/06 , A61K47/12 , A61K47/02 , C30B29/54 , C30B7/08 , A61K47/38 , A61K9/00
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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Patent Agency Ranking
![PROCESS FOR THE PREPARATION OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6-DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CARBONITRILE](/abs-image/US/2019/04/11/US20190106438A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190106438A1
公开(公告)日：2019-04-11
申请号：US16156955
申请日：2018-10-10
Applicant: Loxo Oncology, Inc. , Array BioPharma Inc.
Inventor： Charles Todd Eary , Stacey Spencer , Zack Crane , Katelyn Chando , Sylvie Asselin , Weidong Liu , Mike Welch , Adam Cook , Gabrielle R. Kolakowski , Andrew T. Metcalf , David A. Moreno , Tony P. Tang
IPC: C07D519/00
Abstract: In some embodiments, provided herein is a process for preparing a compound of Formula I or a pharmaceutically acceptable salt thereof, as disclosed herein.
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公开(公告)号：US09980944B2
公开(公告)日：2018-05-29
申请号：US15445393
申请日：2017-02-28
Applicant: Array BioPharma, Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: A61K31/4184 , A61K9/00 , A61K9/20 , A61K45/06
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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公开(公告)号：US20160168103A1
公开(公告)日：2016-06-16
申请号：US14974655
申请日：2015-12-18
Applicant: Array BioPharma, Inc. , Novartis Pharma AG
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: C07D235/06 , A61K47/12 , A61K47/02 , A61K47/26 , A61K47/38
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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![Process for the preparation of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile](/abs-image/US/2020/08/18/US10745419B2/abs.jpg.150x150.jpg)
公开(公告)号：US10745419B2
公开(公告)日：2020-08-18
申请号：US16156955
申请日：2018-10-10
Applicant: Loxo Oncology, Inc. , Array BioPharma Inc.
Inventor： Charles Todd Eary , Stacey Spencer , Zack Crane , Katelyn Chando , Sylvie Asselin , Weidong Liu , Mike Welch , Adam Cook , Gabrielle R. Kolakowski , Andrew T. Metcalf , David A. Moreno , Tony P. Tang
IPC: C07D519/00 , C07D471/04
Abstract: In some embodiments, provided herein is a process for preparing a compound of Formula I or a pharmaceutically acceptable salt thereof, as disclosed herein.
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公开(公告)号：US20170087156A1
公开(公告)日：2017-03-30
申请号：US15311148
申请日：2015-05-14
Applicant: Array BioPharma Inc.
Inventor： Shelley Allen , Steven W. Andrews , Brian Baer , Zackary Crane , Weidong Liu , Daniel John Watson
IPC: A61K31/506 , A61K9/00 , C07D207/16 , C07D403/14 , A61K45/06
CPC classification number: A61K31/506 , A61K9/0053 , A61K45/06 , C07D207/16 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
Abstract: Provided is Compound (I) or a pharmaceutically acceptable salt thereof, which is an inhibitor of TrkA kinase and is useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation and inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, pelvic pain syndrome, diseases related to an imbalance of the regulation of bone remodeling, and diseases resulting from Connective Tissue Growth Factor aberrant signaling.
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