公开(公告)号：US10272072B2

公开(公告)日：2019-04-30

申请号：US15352184

申请日：2016-11-15

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Alexandre Joseph Buckmelter ,  Karl H. Clodfelter ,  Peter Dragovich ,  Francis Gosselin ,  Bingsong Han ,  Jian Lin ,  Dominic J. Reynolds ,  Bruce Roth ,  Chase C. Smith ,  Zhongguo Wang ,  Po-Wai Yuen ,  Xiaozhang Zheng

IPC: A61K31/4353 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/4355 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/496 ,  A61K31/519 ,  A61K31/55 ,  A61K45/06 ,  C07D487/04 ,  C07D491/048

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

公开(公告)号：US20180244694A1

公开(公告)日：2018-08-30

申请号：US15962333

申请日：2018-04-25

Applicant: Genentech, Inc.

Inventor： Yu Jiang ,  Guosheng Wu ,  Po-Wai Yuen ,  Elisia Villemure ,  Jacob Schwarz ,  Cuong Ly ,  Benjamin Sellers ,  Matthew Volgraf

IPC: C07D513/14 ,  C07D519/00 ,  C07D513/04 ,  C07D513/10

CPC classification number: C07D513/14 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00

Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US10772874B2

公开(公告)日：2020-09-15

申请号：US16538208

申请日：2019-08-12

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Alexandre J. Buckmelter ,  Karl H. Clodfelter ,  Peter Dragovich ,  Francis Gosselin ,  Bingsong Han ,  Jian Lin ,  Dominic J. Reynolds ,  Bruce Roth ,  Chase C. Smith ,  Zhongguo Wang ,  Po-Wai Yuen ,  Xiaozhang Zheng

IPC: C07D491/048 ,  C07D487/04 ,  A61K31/4355 ,  A61K31/4365 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/497 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

公开(公告)号：US20200283403A1

公开(公告)日：2020-09-10

申请号：US16824885

申请日：2020-03-20

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Alexandre J. Buckmelter ,  Karl H. Clodfelter ,  Bingsong Han ,  Jian Lin ,  Dominic J. Reynolds ,  Chase C. Smith ,  Zhongguo Wang ,  Xiaozhang Zheng ,  Po-Wai Yuen

IPC: C07D401/12 ,  C07C317/42 ,  C07D213/54 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D213/84 ,  C07D471/04 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4545 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/40

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

公开(公告)号：US10730889B2

公开(公告)日：2020-08-04

申请号：US15936086

申请日：2018-03-26

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Peter Dragovich ,  Xiongcai Liu ,  Snahel Patel ,  Po-Wai Yuen ,  Mark Zak ,  Guiling Zhao ,  Yamin Zhang ,  Xiaozhang Zheng

IPC: C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  A61K31/438 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/513

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US20190105307A1

公开(公告)日：2019-04-11

申请号：US16212360

申请日：2018-12-06

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Alexandre J. Buckmelter ,  Karl H. Clodfelter ,  Peter Dragovich ,  Francis Gosselin ,  Bingsong Han ,  Jian Lin ,  Dominic J. Reynolds ,  Bruce Roth ,  Chase C. Smith ,  Zhongguo Wang ,  Po-Wai Yuen ,  Xiaozhang Zheng

IPC: A61K31/4355 ,  A61K31/496 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/497 ,  A61K31/519 ,  C07D471/04 ,  A61K31/55 ,  C07D487/04 ,  C07D491/048 ,  A61K45/06 ,  C07D495/04 ,  C07D491/04 ,  A61K31/5377

CPC classification number: A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/496 ,  A61K31/497 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

公开(公告)号：US09988400B2

公开(公告)日：2018-06-05

申请号：US15094687

申请日：2016-04-08

Applicant: Genentech, Inc.

Inventor： Yu Jiang ,  Guosheng Wu ,  Po-Wai Yuen ,  Elisia Villemure ,  Jacob Schwarz ,  Cuong Ly ,  Benjamin Sellers ,  Matthew Volgraf

IPC: C07D513/04 ,  C07D513/10 ,  C07D513/14 ,  C07D519/00

CPC classification number: C07D513/14 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00

Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US09822129B2

公开(公告)日：2017-11-21

申请号：US14382210

申请日：2013-03-01

Applicant: GENENTECH,INC. ,  FORMA TM, LLC ,  Po-Wai Yuen

Inventor： Kenneth W Bair ,  Timm R Baumeister ,  Peter Dragovich ,  Xiongcai Liu ,  Snahel Patel ,  Po-Wai Yuen ,  Mark Zak ,  Guiling Zhao ,  Yamin Zhang ,  Xiaozhang Zheng

IPC: C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  A61K31/438 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06

CPC classification number: C07D519/00 ,  A61K31/438 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US20160222033A1

公开(公告)日：2016-08-04

申请号：US15094687

申请日：2016-04-08

Applicant: Genentech, Inc.

Inventor： Jiang Yu ,  Guosheng Wu ,  Po-Wai Yuen ,  Elisia Villemure ,  Jacob Schwarz ,  Cuong Ly ,  Benjamin Sellers ,  Volgraf Matthew

IPC: C07D513/14 ,  C07D513/10 ,  C07D519/00 ,  C07D513/04

CPC classification number: C07D513/14 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00

Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

Abstract translation: 本发明涉及某些噻唑并嘧啶酮化合物，包含这些化合物的药物组合物，以及使用这些化合物的治疗方法。

公开(公告)号：US09346815B2

公开(公告)日：2016-05-24

申请号：US14720323

申请日：2015-05-22

Applicant: Genentech, Inc.

Inventor： Mark Edward Zak ,  Nicholas Charles Ray ,  Simon Charles Goodacre ,  Rohan Mendonca ,  Terry Kellar ,  Yun-Xing Cheng ,  Wei Li ,  Po-Wai Yuen

IPC: C07D487/04 ,  A61K31/519 ,  A61P11/06 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/519 ,  C07D487/04 ,  C07D519/00

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract translation: 本文描述了式（00A）的化合物和用作Janus激酶抑制剂的方法。