公开(公告)号：US20210171545A1

公开(公告)日：2021-06-10

申请号：US16944581

申请日：2020-07-31

Applicant: Integral Early Discovery, Inc. ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Peter Dragovich ,  Xiongcai Liu ,  Snahel Patel ,  Po-Wai Yuen ,  Mark Zak ,  Guiling Zhao ,  Yamin Zhang ,  Xiaozhang Zheng

IPC: C07D519/00 ,  C07D495/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  A61K31/438 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/513

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US10696692B2

公开(公告)日：2020-06-30

申请号：US14382141

申请日：2013-03-01

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W Bair ,  Timm R Baumeister ,  Alexandre J Buckmelter ,  Karl H Clodfelter ,  Peter Dragovich ,  Francis Gosselin ,  Janet Gunzner-Toste ,  Bingsong Han ,  Jian Lin ,  Xiongcai Liu ,  Dominic J Reynolds ,  Chase C Smith ,  Zhongguo Wang ,  Mark Zak ,  Yamin Zhang ,  Guiling Zhao ,  Xiaozhang Zheng ,  Po-Wai Yuen

IPC: A61K51/00 ,  A61M36/14 ,  C07D519/00 ,  C07D471/04 ,  C07D495/04 ,  C07D487/04 ,  C07D491/048 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/551 ,  A61K45/06

Abstract: The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US10307426B2

公开(公告)日：2019-06-04

申请号：US15984747

申请日：2018-05-21

Applicant: Genentech, Inc.

Inventor： Mark Zak ,  F. Anthony Romero ,  Yun-Xing Cheng

IPC: C07D487/04 ,  A61K31/519 ,  A61P11/06 ,  A61P29/00

Abstract: Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20190071404A1

公开(公告)日：2019-03-07

申请号：US16181228

申请日：2018-11-05

Applicant: Genentech, Inc.

Inventor： James John Crawford ,  Mark Zak ,  Terry Kellar ,  Yun-Xing Cheng ,  Wei Li ,  F. Anthony Romero ,  Paul Gibbons ,  Guiling Zhao ,  Gregory Hamilton ,  Simon Charles Goodacre

IPC: C07D231/40 ,  C07D401/04 ,  C07D405/04 ,  C07D403/08 ,  C07D409/14 ,  C07D401/14 ,  C07D405/12

Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.

公开(公告)号：US20180354959A1

公开(公告)日：2018-12-13

申请号：US16104347

申请日：2018-08-17

Applicant: Genentech, Inc.

Inventor： Mark Zak ,  Terry Kellar ,  Paul Gibbons

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Compounds of Formula (I): salts thereof and methods of use as Janus kinase inhibitors are described herein.

公开(公告)号：US20180339998A1

公开(公告)日：2018-11-29

申请号：US15936086

申请日：2018-03-26

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Peter Dragovich ,  Xiongcai Liu ,  Snahel Patel ,  Po-Wai Yuen ,  Mark Zak ,  Guiling Zhao ,  Yamin Zhang ,  Xiaozhang Zheng

IPC: C07D519/00 ,  A61K45/06 ,  C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/496 ,  A61K31/497 ,  A61K31/513 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/438 ,  C07D495/04 ,  C07D491/048 ,  C07D487/04 ,  A61K31/501

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US08722661B2

公开(公告)日：2014-05-13

申请号：US13911601

申请日：2013-06-06

Applicant: Genentech, Inc.

Inventor： Nancy-Ellen Haynes ,  Johannes Hermann ,  Kyungjin Kim ,  Nathan Robert Scott ,  Lin Yi ,  Mark Zak

IPC: A61K31/00 ,  C07D401/00 ,  C07D487/00 ,  C07D471/02

CPC classification number: C07D487/04 ,  C07D471/04

Abstract: There are provided compounds of the formula (I) wherein Q, R1 and R2 are defined herein. The compounds have activity as anticancer agents.

Abstract translation: 提供式（I）化合物，其中Q，R 1和R 2在本文中定义。 该化合物具有作为抗癌剂的活性。