公开(公告)号：US09645076B2

公开(公告)日：2017-05-09

申请号：US14583288

申请日：2014-12-26

Applicant: General Electric Company

Inventor： Nagapriya Kavoori Sethumadhavan ,  Sandip Maity ,  Samhitha Palanganda Poonacha ,  Moitrayee Mukherjee ,  Purbasha Halder ,  Harish Sasikumar ,  Prasenjit Pandey

IPC: G01N21/25 ,  G01N21/31 ,  G01J3/433 ,  G01N21/39 ,  G01N21/03 ,  G01N21/3504

CPC classification number: G01N21/31 ,  G01J3/433 ,  G01N21/03 ,  G01N21/3504 ,  G01N21/39 ,  G01N2201/061

Abstract: A method for determining a concentration of at least one individual gas present in a gas-mixture includes irradiating a first component by incident modulated-light-beams characterized by a determined absorption wavelength range, modulation frequencies and a modulation amplitudes to generate first transmitted-light-beams, irradiating a second component, comprising a determined concentration of the at least one individual gas, by the first incident modulated-light-beams to generate second transmitted-light-beams, generating noise signals representative of a characteristic of the first transmitted-light-beams, generating noise-free signals representative of a characteristic of the second transmitted-light-beams, selecting an optimal modulation frequency and an optimal modulation amplitude from the modulation frequencies and the modulation amplitudes based on the noise signals and the noise-free signals, and determining a concentration of the at least one individual gas in the gas-mixture based on the optimal modulation frequency and the optimal modulation amplitude of the determined absorption wavelength range.

公开(公告)号：US20160187251A1

公开(公告)日：2016-06-30

申请号：US14583288

申请日：2014-12-26

Applicant: General Electric Company

Inventor： Nagapriya Kavoori Sethumadhavan ,  Sandip Maity ,  Samhitha Palanganda Poonacha ,  Moitrayee Mukherjee ,  Purbasha Halder ,  Harish Sasikumar ,  Prasenjit Pandey

IPC: G01N21/31 ,  G01N21/03

CPC classification number: G01N21/31 ,  G01J3/433 ,  G01N21/03 ,  G01N21/3504 ,  G01N21/39 ,  G01N2201/061

Abstract: A method for determining a concentration of at least one individual gas present in a gas-mixture includes irradiating a first component by incident modulated-light-beams characterized by a determined absorption wavelength range, modulation frequencies and a modulation amplitudes to generate first transmitted-light-beams, irradiating a second component, comprising a determined concentration of the at least one individual gas, by the first incident modulated-light-beams to generate second transmitted-light-beams, generating noise signals representative of a characteristic of the first transmitted-light-beams, generating noise-free signals representative of a characteristic of the second transmitted-light-beams, selecting an optimal modulation frequency and an optimal modulation amplitude from the modulation frequencies and the modulation amplitudes based on the noise signals and the noise-free signals, and determining a concentration of the at least one individual gas in the gas-mixture based on the optimal modulation frequency and the optimal modulation amplitude of the determined absorption wavelength range.

Abstract translation: 用于确定气体混合物中存在的至少一种单独气体的浓度的方法包括通过入射的调制光束照射第一分量，其特征在于确定的吸收波长范围，调制频率和调制幅度，以产生第一透射光 - 通过所述第一入射调制光束照射包含所述至少一种单独气体的确定浓度的第二组分以产生第二透射光束，产生表示所述第一透射光束的特性的噪声信号， 产生表示第二透射光束的特性的无噪声信号，基于噪声信号和无噪声从调制频率和调制幅度中选择最佳调制频率和最佳调制幅度 信号，并确定气体混合物中的至少一种单独气体的浓度 基于所确定的吸收波长范围的最佳调制频率和最佳调制幅度。

公开(公告)号：US20150059435A1

公开(公告)日：2015-03-05

申请号：US14467304

申请日：2014-08-25

Applicant: General Electric Company

Inventor： Niloy Choudhury ,  Nagapriya Kavoori Sethumadhavan ,  Sandip Maity

IPC: G01N21/17

CPC classification number: G01N21/1702 ,  G01J3/433 ,  G01N21/3577 ,  G01N21/39 ,  G01N21/85 ,  G01N29/222 ,  G01N29/2425 ,  G01N29/30 ,  G01N33/2841 ,  G01N33/2847 ,  G01N2021/1704 ,  G01N2201/06113 ,  G01N2201/067 ,  G01N2291/02809

Abstract: A system and a method for detecting of components in a sample fluid includes a first chamber having a sample fluid and a second chamber coupled to the first chamber, wherein the second chamber has a reference fluid. The system includes a modulated light source for emitting a modulated light beam to the sample fluid and the reference fluid, to generate a first acoustic signal in the first chamber and a second acoustic signal in the second chamber. The system further includes a pressure sensor disposed between the first chamber and the second chamber, for detecting a difference between the first acoustic signal and the second acoustic signal. The system includes a processor based module communicatively coupled to the pressure sensor and configured to receive a signal representative of the difference and determine at least one of a component and the concentration of the component in the sample fluid.

Abstract translation: 用于检测样品流体中的组分的系统和方法包括具有样品流体的第一室和联接到第一室的第二室，其中第二室具有参考流体。 该系统包括用于将调制的光束发射到样品流体和参考流体的调制光源，以在第一室中产生第一声信号，并在第二室中产生第二声信号。 该系统还包括设置在第一室和第二室之间的压力传感器，用于检测第一声信号和第二声信号之间的差。 该系统包括基于处理器的模块，其通信地耦合到压力传感器并且被配置为接收代表该差异的信号，并且确定样品流体中的组分和组分的浓度中的至少一个。

公开(公告)号：US20200181560A1

公开(公告)日：2020-06-11

申请号：US16316297

申请日：2017-06-22

Applicant: General Electric Company

Inventor： Prashanth Hosabettu Mohan ,  Sandip Maity ,  Nagapriya Kavoori Sethumadhavan ,  Swapnil Puranik ,  Li Ou

IPC: C12M1/34 ,  C12M3/06 ,  C12M1/36

Abstract: A microfluidic device (100) is disclosed for in-process monitoring of cell culture conditions including for example one or more of: cell density; cell viability; secreted proteins; protein analysis; epitope markers; concentrations of metabolites or nutrients and antigenic determinations; the device comprising: a cell inlet path (120); plural fluid reservoirs (130) in fluid communication with the cell input path, a cell analysis area (160) in fluid communication with the path and reservoirs, and a waste storage volume (166) also in fluid communication with the cell analysis area, the device being operable to cause a primary fluid flow along the inlet path to the analysis area, and to selectively cause secondary fluid flow(s) into the path from none, one or more of the selected reservoirs to combine, if one or more of the reservoirs are selected, with the primary fluid flow from the cell inlet path, in each case for analysis at the cell analysis area, the device being further operable to cause a fluid flow of the primary and any combined secondary flows from the cell analysis area into the waste storage volume.

公开(公告)号：US09689795B2

公开(公告)日：2017-06-27

申请号：US14668099

申请日：2015-03-25

Applicant: General Electric Company

Inventor： Mark Marshall Meyers ,  David Peter Robinson ,  Sandip Maity ,  Nagapriya Kavoori Sethumadhavan

IPC: G01J3/02 ,  G01N21/25 ,  G01N33/00 ,  G01J3/433 ,  G01N21/03 ,  G01J3/42 ,  G01N21/3504

CPC classification number: G01N21/255 ,  G01J3/021 ,  G01J3/42 ,  G01J3/433 ,  G01N21/031 ,  G01N21/3504 ,  G01N33/0009

Abstract: A system is presented. The system includes an absorption cell filled-with a gas-mixture, a mirror-cum-window comprising a first portion that acts as a first mirror and a second portion that acts as a first window, a second mirror, a plurality of radiation sources to generate a plurality of light beams directed into the absorption cell through the first window followed by reflection of the plurality of light beams between the first mirror and the second mirror to irradiate the gas-mixture resulting in generation of a plurality of transmitted light beams passing out of the absorption cell through the second window, a detector that detects at least one characteristic of the plurality of transmitted light beams resulting in generation of one or more response signals, and a processing subsystem that analyzes the gas-mixture at least based on the one or more response signals.

公开(公告)号：US20170010250A1

公开(公告)日：2017-01-12

申请号：US15275089

申请日：2016-09-23

Applicant: General Electric Company

Inventor： Sandip Maity ,  Nagapriya Kavoori Sethurnadhavan ,  Samhitha Palanganda Poonacha ,  Prashanth Raghavendra Prasad

IPC: G01N33/28 ,  G01N25/00

CPC classification number: G01N33/2841 ,  G01N21/3504 ,  G01N25/005

Abstract: A system, comprising at least one source for irradiating electromagnetic radiation into a sample fluid and a reference fluid resulting in a change in a temperature of the sample fluid and a change in a temperature of the reference fluid, and a processing subsystem that monitors and determines a concentration of a gas of interest dissolved in the sample fluid based upon a difference between the change in the temperature of the sample fluid and the change in the temperature of the reference fluid, wherein the reference fluid does not contain the gas of interest, and the electromagnetic radiation has a wavelength range corresponding to a spectral absorption range of the gas of interest.

Abstract translation: 一种系统，包括用于将电磁辐射照射到样品流体中的至少一个源和导致样品流体的温度变化和参考流体的温度变化的参考流体，以及监测和确定 基于样品流体的温度变化与参考流体的温度变化之间的差异，溶解在样品流体中的目标气体的浓度，其中参考流体不包含感兴趣的气体，以及 电磁辐射具有对应于感兴趣的气体的光谱吸收范围的波长范围。

公开(公告)号：US20170003218A1

公开(公告)日：2017-01-05

申请号：US14278335

申请日：2014-05-15

Applicant: General Electric Company

Inventor： Rachit Sharma ,  Chayan Mitra ,  Sandip Maity ,  Vinayak Tilak ,  Xiaoyong Liu ,  Anthony Kowal ,  Chong Tao

IPC: G01N21/39 ,  G01N21/03 ,  G01N21/27

CPC classification number: G01N21/39 ,  G01N21/274 ,  G01N33/004 ,  G01N2021/399 ,  G01N2201/1218

Abstract: A method includes receiving a gas mixture at a first pressure including at least a primary gas and a secondary gas and changing a pressure of the received gas mixture from the first pressure to a second pressure. Further, the method includes determining a spectra of the gas mixture at the second pressure, wherein at least the first spectral line of the primary gas is spectrally distinguished from at least the second spectral line of the secondary gas, identifying a peak wavelength associated with the spectrally distinguished first spectral line of the primary gas based on at least two wavelengths of the secondary gas corresponding to at least two peak amplitudes in the spectra of the gas mixture, and determining a concentration of the primary gas based on the identified peak wavelength associated with the spectrally distinguished first spectral line of the primary gas.

Abstract translation: 一种方法包括在包括至少初级气体和次级气体的第一压力下接收气体混合物，并将接收到的气体混合物的压力从第一压力改变到第二压力。 此外，该方法包括在第二压力下确定气体混合物的光谱，其中至少第一主气体的第一谱线与第二气体的至少第二谱线进行光谱区分，识别与第二气体相关联的峰值波长 基于对应于气体混合物的光谱中的至少两个峰值振幅的二次气体的至少两个波长的主气体的谱分辨第一谱线，以及基于与所述气体混合物相关联的所识别的峰值波长来确定初级气体的浓度 主要气体的光谱区分第一谱线。

公开(公告)号：US20160282260A1

公开(公告)日：2016-09-29

申请号：US14668099

申请日：2015-03-25

Applicant: General Electric Company

Inventor： Mark Marshall Meyers ,  David Peter Robinson ,  Sandip Maity ,  Nagapriya Kavoori Sethumadhavan

IPC: G01N21/25 ,  G01N33/00

CPC classification number: G01N21/255 ,  G01J3/021 ,  G01J3/42 ,  G01J3/433 ,  G01N21/031 ,  G01N21/3504 ,  G01N33/0009

Abstract: A system is presented. The system includes an absorption cell filled-with a gas-mixture, a mirror-cum-window comprising a first portion that acts as a first mirror and a second portion that acts as a first window, a second mirror, a plurality of radiation sources to generate a plurality of light beams directed into the absorption cell through the first window followed by reflection of the plurality of light beams between the first mirror and the second mirror to irradiate the gas-mixture resulting in generation of a plurality of transmitted light beams passing out of the absorption cell through the second window, a detector that detects at least one characteristic of the plurality of transmitted light beams resulting in generation of one or more response signals, and a processing subsystem that analyzes the gas-mixture at least based on the one or more response signals.

Abstract translation: 提出了一个系统。 该系统包括填充有气体混合物的吸收单元，包括充当第一反射镜的第一部分和充当第一窗口的第二部分的反射镜与窗口，第二反射镜，多个辐射源 以通过第一窗口产生引导到吸收单元中的多个光束，随后在第一反射镜和第二反射镜之间反射多个光束，以照射气体混合物，从而产生通过的多个透射光束 通过第二窗口离开吸收单元，检测器，其检测导致产生一个或多个响应信号的多个透射光束的至少一个特性;以及处理子系统，至少基于该气体混合物分析气体混合物 一个或多个响应信号。

公开(公告)号：US10024787B2

公开(公告)日：2018-07-17

申请号：US14278335

申请日：2014-05-15

Applicant: General Electric Company

Inventor： Rachit Sharma ,  Chayan Mitra ,  Sandip Maity ,  Vinayak Tilak ,  Xiaoyong Liu ,  Anthony Kowal ,  Chong Tao

IPC: G01N21/39 ,  G01N21/03 ,  G01N21/27 ,  G01N33/00

Abstract: A method includes receiving a gas mixture at a first pressure including at least a primary gas and a secondary gas and changing a pressure of the received gas mixture from the first pressure to a second pressure. Further, the method includes determining a spectra of the gas mixture at the second pressure, wherein at least the first spectral line of the primary gas is spectrally distinguished from at least the second spectral line of the secondary gas, identifying a peak wavelength associated with the spectrally distinguished first spectral line of the primary gas based on at least two wavelengths of the secondary gas corresponding to at least two peak amplitudes in the spectra of the gas mixture, and determining a concentration of the primary gas based on the identified peak wavelength associated with the spectrally distinguished first spectral line of the primary gas.

公开(公告)号：US09759610B2

公开(公告)日：2017-09-12

申请号：US13950733

申请日：2013-07-25

Applicant: General Electric Company

Inventor： Sandip Maity ,  Nagapriya Kavoori Sethumadhavan ,  Shashank Sinha

IPC: G01J5/00 ,  G01N21/3504 ,  G01N25/48 ,  G01N21/359

CPC classification number: G01J5/0014 ,  G01N21/3504 ,  G01N21/359 ,  G01N25/4873

Abstract: A method for dissolved gas analysis is presented. The method includes the steps of irradiating a fluid with electromagnetic radiation; and determining a concentration of a gas as a function of a temperature change of the fluid in response to the irradiation. A device for such an analysis of dissolved gases in a fluid, and a system having such device are also described.