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公开(公告)号：US20180237764A1
公开(公告)日：2018-08-23
申请号：US15955377
申请日：2018-04-17
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US09708597B2
公开(公告)日：2017-07-18
申请号：US14158106
申请日：2014-01-17
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
CPC classification number: C12N13/00 , A61B5/150755 , C12M35/02 , G01N33/49 , H03K3/53
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US09452199B2
公开(公告)日：2016-09-27
申请号：US14157819
申请日：2014-01-17
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Duh-Lan Lee , Allen Lawrence Garner
CPC classification number: A61K38/1858 , A61K35/19 , C12N13/00 , G01N33/48707 , G01N33/49
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
Abstract translation: 公开了用于释放生长因子的方法和系统。 在某些实施方案中，将血液样品暴露于一个或多个电脉冲的序列以触发样品中生长因子的释放。 在某些实施方案中，生长因子释放不伴随血液样品内的凝血。
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公开(公告)号：US09238808B2
公开(公告)日：2016-01-19
申请号：US13911987
申请日：2013-06-06
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Andrew Soliz Torres , Allen Lawrence Garner
CPC classification number: C12N13/00 , H02J7/0052 , H02J2007/0059 , H03K3/57 , Y10T307/707
Abstract: A pulse generation system for applying electric pulses across a load includes a first plurality of energy storage modules connected in series on a positive chain and configured to apply a positive potential to the load and a second plurality of energy storage modules connected in series on a negative chain and configured to apply a negative potential to the load. Each energy storage module of the positive chain and the negative chain includes a rectifier and a storage element, and at least one control element.
Abstract translation: 用于在负载上施加电脉冲的脉冲发生系统包括串联连接在正极链上并被配置为向负载施加正电位的第一多个能量存储模块和串联连接在负极上的第二多个能量存储模块 并配置为向负载施加负电位。 正链和负链的每个储能模块包括整流器和存储元件，以及至少一个控制元件。
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Patent Agency Ranking
公开(公告)号：US20140363881A1
公开(公告)日：2014-12-11
申请号：US13911987
申请日：2013-06-06
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Andrew Soliz Torres , Allen Lawrence Garner
CPC classification number: C12N13/00 , H02J7/0052 , H02J2007/0059 , H03K3/57 , Y10T307/707
Abstract: A pulse generation system for applying electric pulses across a load includes a first plurality of energy storage modules connected in series on a positive chain and configured to apply a positive potential to the load and a second plurality of energy storage modules connected in series on a negative chain and configured to apply a negative potential to the load. Each energy storage module of the positive chain and the negative chain includes a rectifier and a storage element, and at least one control element.
Abstract translation: 用于在负载上施加电脉冲的脉冲发生系统包括串联连接在正极链上并被配置为向负载施加正电势的第一多个能量存储模块和串联连接在负极上的第二多个能量存储模块 并配置为向负载施加负电位。 正链和负链的每个储能模块包括整流器和存储元件，以及至少一个控制元件。
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公开(公告)号：US11525768B2
公开(公告)日：2022-12-13
申请号：US16538616
申请日：2019-08-12
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US11464829B2
公开(公告)日：2022-10-11
申请号：US16514662
申请日：2019-07-17
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
IPC: A61K38/18 , A61K35/19 , G01N33/49 , C12N13/00 , G01N33/487
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US20150203836A1
公开(公告)日：2015-07-23
申请号：US14158106
申请日：2014-01-17
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
CPC classification number: C12N13/00 , A61B5/150755 , C12M35/02 , G01N33/49 , H03K3/53
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
Abstract translation: 根据本公开，描述了通过电容耦合将样本暴露于一个或多个电脉冲。 在某些实施方案中，样品可以是使用脉冲电场处理或修饰的生物样品。 在某些实施例中，电脉冲可以使用电容耦合传送到负载。 在其他实施例中，电脉冲可以是双极性脉冲。
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公开(公告)号：US20140363412A1
公开(公告)日：2014-12-11
申请号：US13912050
申请日：2013-06-06
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Antonio Caiafa , Brian Duh-Lan Lee , Nicole Evelyn LaPlante , Andrew Soliz Torres , Allen Lawrence Garner
CPC classification number: A61K35/19 , A61K41/00 , A61N1/00 , C12N5/0644 , C12N13/00
Abstract: Embodiments of the disclosure relate to platelet activation and/or aggregation using electric pulses. In one embodiment, a platelet-containing sample is exposed to electric pulses. At least one of the electric pulses has a duration greater than 1 microsecond and a field strength below 50 kV/cm. In another embodiment, the electric pulses may be designed with particular field strengths and durations.
Abstract translation: 本公开的实施方案涉及使用电脉冲的血小板活化和/或聚集。 在一个实施方案中，将含血小板的样品暴露于电脉冲。 电脉冲中的至少一个具有大于1微秒的持续时间和低于50kV / cm的场强。 在另一个实施例中，电脉冲可以被设计为具有特定的场强和持续时间。
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