公开(公告)号：US10788494B2

公开(公告)日：2020-09-29

申请号：US15914094

申请日：2018-03-07

Applicant: Genentech, Inc.

Inventor： Feny Gunawan ,  Yi-Chun Hsiao ,  Denise C. Krawitz ,  Margaret S. Lin ,  Martin Vanderlaan ,  Rajesh Vij ,  Inn H. Yuk ,  Judith Zhu-Shimoni

IPC: C07K16/40 ,  G01N33/573 ,  G01N33/577

Abstract: Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.

公开(公告)号：US20180364236A1

公开(公告)日：2018-12-20

申请号：US15914099

申请日：2018-03-07

Applicant: Genentech, Inc.

Inventor： Feny Gunawan ,  Yi-Chun Hsiao ,  Denise C. Krawitz ,  Margaret S. Lin ,  Martin Vanderlaan ,  Rajesh Vij ,  Inn H. Yuk ,  Judith Zhu-Shimoni

IPC: G01N33/573 ,  G01N33/577 ,  C07K16/40

Abstract: Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.

公开(公告)号：US20160320391A1

公开(公告)日：2016-11-03

申请号：US15065615

申请日：2016-03-09

Applicant: Genentech, Inc.

Inventor： Feny Gunawan ,  Yi-Chun Hsiao ,  Denise C. Krawitz ,  Margaret S. Lin ,  Martin Vanderlaan ,  Rajesh Vij ,  Inn H. Yuk ,  Judith Zhu-Shimoni

IPC: G01N33/573 ,  C07K16/40 ,  G01N33/577

CPC classification number: G01N33/573 ,  C07K16/40 ,  C07K2317/33 ,  C07K2317/565 ,  G01N33/577 ,  G01N2333/918 ,  G01N2333/92 ,  G01N2500/10

Abstract: Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.

Abstract translation: 提供了结合仓鼠磷脂酶B样2的单克隆和多克隆抗体。 还提供了用于检测和定量仓鼠磷脂酶B样2的方法，例如在重组多肽制备中，以及用于进行这些方法的试剂盒。 还提供筛选或选择表达低水平仓鼠磷脂酶B样2的宿主细胞系或重组多肽表达细胞系的方法。

公开(公告)号：US20130143237A1

公开(公告)日：2013-06-06

申请号：US13689407

申请日：2012-11-29

Applicant: Genentech, Inc.

Inventor： Siminder Atwal ,  Jo-Anne Hongo ,  Mark Lackner ,  Elizabeth Punnoose ,  Bonnee Rubinfeld ,  Rajesh Vij

IPC: G01N33/68 ,  C07K16/30

CPC classification number: G01N33/57434 ,  C07K16/3069 ,  C12N5/0693 ,  C12Y116/01 ,  C12Y301/03048 ,  G01N33/57492 ,  G01N2333/4742 ,  G01N2333/70596 ,  G01N2333/90287 ,  G01N2333/916 ,  G01N2800/52

Abstract: The invention provides methods for diagnosing prostate cancer. The invention also provides novel anti-STEAP-1 antibodies and uses thereof.

Abstract translation: 本发明提供诊断前列腺癌的方法。 本发明还提供新的抗STEAP-1抗体及其用途。