公开(公告)号：US10690639B2

公开(公告)日：2020-06-23

申请号：US15809239

申请日：2017-11-10

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger ,  Christoph Hollnagel

IPC: G01N30/60 ,  G01N30/14 ,  G01N30/24 ,  G01N30/20 ,  G01N30/02 ,  G01N30/38

Abstract: A liquid chromatography system includes a separation column, a trap column, and a first switching valve. The first switching valve is adapted to assume a first switching position for bringing a sample into the trap column in a first flow direction. The switching valve is also adapted to assume a second switching position for fluidly connecting the trap column with the separation column and providing a flow from the trap column to the separation column in a second flow direction. The second flow direction is opposite to the first flow direction. The first switching valve is adapted to assume a third switching position for fluidly connecting the trap column, with the separation column and providing a flow from the trap column to the separation column in the first flow direction.

公开(公告)号：US20230349866A1

公开(公告)日：2023-11-02

申请号：US18349110

申请日：2023-07-07

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger

IPC: G01N30/20

CPC classification number: G01N30/20 ,  G01N30/22

Abstract: A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.

公开(公告)号：US11733214B2

公开(公告)日：2023-08-22

申请号：US18145890

申请日：2022-12-23

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger

IPC: G01N30/20 ,  G01N30/22 ,  G01N30/32 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/22 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/207

Abstract: A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.

公开(公告)号：US20220163491A1

公开(公告)日：2022-05-26

申请号：US17667139

申请日：2022-02-08

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger ,  Christoph Hollnagel

IPC: G01N30/20 ,  B01D15/22 ,  G01N30/60

Abstract: A system for component interconnection for use in liquid chromatography includes a first switching valve and a second switching valve. A first connecting line fluidly connects the first switching valve to the second switching valve. A second connecting line fluidly connects the first switching valve to the second switching valve. A metering device is located in the first connecting line.

公开(公告)号：US11280768B2

公开(公告)日：2022-03-22

申请号：US15809270

申请日：2017-11-10

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger ,  Christoph Hollnagel

IPC: G01N30/20 ,  B01D15/22 ,  G01N30/60 ,  G01N30/24 ,  G01N30/08 ,  G01N30/46 ,  G01N30/02

Abstract: A system for component interconnection for use in liquid chromatography includes a first switching valve and a second switching valve. A first connecting line fluidly connects the first switching valve to the second switching valve. A second connecting line fluidly connects the first switching valve to the second switching valve. A metering device is located in the first connecting line.

公开(公告)号：US10722816B2

公开(公告)日：2020-07-28

申请号：US15991823

申请日：2018-05-29

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann Hochgraeber ,  Thomas Wachinger

IPC: G01N30/34 ,  B01D15/16

Abstract: The invention relates to a method for setting a gradient delay volume GDV of a liquid chromatography system for a chromatography run in liquid chromatography, in particular a high-performance liquid chromatography system, in which a desired value GDVtarget of a gradient delay volume of the liquid chromatography system is ascertained or predefined and, if the value GDVtarget deviates from a specific fixed value GDVactual of a liquid chromatography system, this value GDVtarget is set in a range 0≤ΔGDV=GDVtarget−GDVactual≤Vmax of a volume of a volume adjustment device 5. Furthermore, the invention relates to an automatic sampler for carrying out such a method.

公开(公告)号：US10473631B2

公开(公告)日：2019-11-12

申请号：US15190529

申请日：2016-06-23

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger

IPC: G01N30/20 ,  G01N30/24

Abstract: A sampler for liquid chromatography is described. The sampler includes an injection valve and a sample loop. The injection valve includes one waste port, two sample loop ports, and two high-pressure ports. The sample loop port includes a first loop part and a second loop part. The injection valve can be configured to have LOAD position and INJECT position. The injection valve can also be configured to have one or more additional positions such as a FULL PURGE position, a PUMP PURGE position, and a NEGATIVE PRESSURE position.

公开(公告)号：US12000805B2

公开(公告)日：2024-06-04

申请号：US17072997

申请日：2020-10-16

Applicant: Dionex Softron GmbH

Inventor： Christoph Hollnagel ,  Hermann Hochgraeber ,  Thomas Wachinger

IPC: G01N30/20 ,  G01N30/14 ,  G01N30/22 ,  G01N30/36

CPC classification number: G01N30/20 ,  G01N30/14 ,  G01N2030/201 ,  G01N2030/207 ,  G01N30/22 ,  G01N30/36

Abstract: A method of introducing a sample into a separation column includes introducing the sample into a trap column, isolating the trap column from ambient atmosphere and pressurizing the trap column to a first pressure while the trap column is isolated from ambient atmosphere, providing a fluid connection between the trap column and the separation column after pressurizing the trap column to the first pressure, supplying the sample from the trap column to the separation column.

公开(公告)号：US11714067B2

公开(公告)日：2023-08-01

申请号：US17218018

申请日：2021-03-30

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger ,  Daniel Buerger

IPC: G01N30/60 ,  F16L19/02

CPC classification number: G01N30/6026 ,  F16L19/0206 ,  F16L19/0212 ,  G01N30/6039

Abstract: A plug for connecting capillaries includes at least one capillary tube, at least one sealing, and at least one pressure piece. The capillary tube includes a first inner diameter and an open end section. The sealing includes a second inner diameter, a first end section and a shape adapted to seal the open end section of the capillary tube when connected. The pressure piece is adapted to exert at least axial pressure and/or force to at least a part of the sealing. The pressure piece is also adapted to host the first end section of the sealing in abutment with the open end section of the capillary tube so that the capillary tube and the sealing are aligned.

公开(公告)号：US20230125365A1

公开(公告)日：2023-04-27

申请号：US18145890

申请日：2022-12-23

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger

IPC: G01N30/20

Abstract: A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.