公开(公告)号：US11377474B2

公开(公告)日：2022-07-05

申请号：US16532344

申请日：2019-08-05

Applicant: AMGEN INC.

Inventor： Jeroen Bezemer ,  Ying Chen ,  Richard Crockett ,  Kevin Crossley ,  Sheng Cui ,  Liang Huang ,  Sian Jones ,  Asher Lower ,  Krishnakumar Ranganathan

IPC: C07K7/06 ,  C07K1/107 ,  A61K38/00

Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.

公开(公告)号：US10407464B2

公开(公告)日：2019-09-10

申请号：US15300209

申请日：2015-04-03

Applicant: AMGEN INC.

Inventor： Jeroen Bezemer ,  Ying Chen ,  Richard Crockett ,  Kevin Crossley ,  Sheng Cui ,  Liang Huang ,  Sian Jones ,  Asher Lower ,  Krishnakumar Ranganathan

IPC: C07K7/06 ,  C07K1/107 ,  A61K38/00

Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease-mineral and bone disorder (CKD-MBD).

公开(公告)号：US20180079777A1

公开(公告)日：2018-03-22

申请号：US15561009

申请日：2016-03-25

Applicant: Amgen Inc.

Inventor： Sheng Cui ,  Krishnakumar Ranganathan ,  Richard Crockett ,  Ying Chen ,  Aleksander Swietlow ,  Kevin Crossley ,  Yun Shi ,  Karel Decroos ,  Etienne Moniotte

IPC: C07K1/02 ,  C07K7/06 ,  C07K1/18

CPC classification number: C07K1/026 ,  C07K1/18 ,  C07K5/081 ,  C07K5/1019 ,  C07K7/06

Abstract: The instant disclosure is directed to solution phase fragment coupling methods for preparing etelcalcetide and its pharmaceutically acceptable salts.

公开(公告)号：US20160016906A1

公开(公告)日：2016-01-21

申请号：US14773436

申请日：2014-03-14

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Sheng Cui ,  Henry Morrison ,  Karthik Nagapudi ,  Shawn Walker ,  Charles Bernard ,  Karl Bennett Hansen ,  Neil Fred Langille ,  Alan Martin Allgeier ,  Steven Mennen ,  Jacqueline Woo ,  Bradley Paul Morgan ,  Alex Muci

IPC: C07D213/75

CPC classification number: C07D213/75 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/496 ,  A61K47/38

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use. Omecamtiv mecarbil (AMG 423, CK-1827452), having the structure:

Abstract translation: 本发明提供了奥美康米卡非二盐酸盐形式，其组合物和药物制剂及其制备和使用方法。 Omecamtiv mecarbil（AMG 423，CK-1827452），具有以下结构：