公开(公告)号：US20130324549A1

公开(公告)日：2013-12-05

申请号：US13897086

申请日：2013-05-17

Applicant: Cytokinetics, Inc.

Inventor： Bradley P. MORGAN ,  David J. Morgans ,  Alex Muci ,  Pu-Ping Lu ,  Erica A. Kraynack ,  Todd Tochimoto

IPC: C07D213/75

CPC classification number: C07D213/75 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/5377

Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Abstract translation: 某些取代的脲衍生物选择性地调节心肌肉瘤，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。

公开(公告)号：US12264133B2

公开(公告)日：2025-04-01

申请号：US17452025

申请日：2021-10-22

Applicant: Cytokinetics, Inc.

Inventor： Bradley Paul Morgan ,  Alex Muci ,  Pu-Ping Lu ,  Todd Tochimoto ,  David J. Morgans, Jr. ,  Erica Anne Kraynack

IPC: C07D241/04 ,  C07D211/56 ,  C07D213/75 ,  C07D239/42 ,  C07D261/14 ,  C07D263/48 ,  C07D271/113 ,  C07D295/26 ,  C07D401/10 ,  C07D401/12 ,  C07D417/00 ,  C07D417/10 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D513/04

Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

公开(公告)号：US11958809B2

公开(公告)日：2024-04-16

申请号：US17448833

申请日：2021-09-24

Applicant: Cytokinetics, Inc.

Inventor： Sheng Cui ,  Henry Morrison ,  Karthik Nagapudi ,  Shawn D. Walker ,  Charles Bernard ,  Karl Bennett Hansen ,  Neil Fred Langille ,  Alan Martin Allgeier ,  Steven M. Mennen ,  Jacqueline C. S. Woo ,  Bradley Paul Morgan ,  Alex Muci

IPC: C07D213/75 ,  A61K9/20 ,  A61K31/444 ,  A61K31/496 ,  A61K47/38 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06

CPC classification number: C07D213/75 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/496 ,  A61K47/38

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

公开(公告)号：US10975034B2

公开(公告)日：2021-04-13

申请号：US16459754

申请日：2019-07-02

Applicant: Cytokinetics, Inc.

Inventor： Bradley Paul Morgan ,  Alex Muci ,  Pu-Ping Lu ,  Erica Anne Kraynack ,  Todd Tochimoto ,  David J. Morgans, Jr.

IPC: C07D213/75 ,  C07D417/00 ,  C07D417/12 ,  C07D513/04 ,  C07D491/04 ,  C07D487/04 ,  C07D417/10 ,  C07D211/56 ,  C07D401/10 ,  C07D295/26 ,  C07D271/113 ,  C07D263/48 ,  C07D261/14 ,  C07D239/42 ,  C07D401/12

Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.