公开(公告)号：US20240270788A1

公开(公告)日：2024-08-15

申请号：US18603661

申请日：2024-03-13

Applicant: AMGEN INC.

Inventor： Rizwan SHARNEZ ,  William TRIEU ,  Marc A. CAPORINI ,  Ron C. Kelly ,  Neill Burt ,  Laura Nicholson ,  Twinkle R. Christian

IPC: C07K1/30 ,  A61K39/395 ,  B01J8/20 ,  B01J8/38 ,  C30B7/00 ,  C30B7/10 ,  C30B30/00 ,  C30B30/02 ,  C30B30/04 ,  G01N24/00 ,  G01N24/08 ,  G01R33/20 ,  G01R33/46

CPC classification number: C07K1/306 ,  A61K39/39591 ,  B01J8/20 ,  B01J8/38 ,  C30B7/00 ,  C30B7/10 ,  C30B30/04 ,  G01N24/087 ,  C30B30/00 ,  C30B30/02 ,  G01N24/00 ,  G01N24/008 ,  G01R33/20 ,  G01R33/46

Abstract: Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.

公开(公告)号：US11958882B2

公开(公告)日：2024-04-16

申请号：US16494165

申请日：2018-03-14

Applicant: AMGEN INC.

Inventor： Rizwan Sharnez ,  William Trieu ,  Marc A. Caporini ,  Ron C. Kelly ,  Neill Burt ,  Laura Nicholson ,  Twinkle R. Christian

IPC: C30B7/10 ,  A61K39/395 ,  B01J8/20 ,  B01J8/38 ,  C07K1/30 ,  C30B7/00 ,  C30B30/04 ,  G01N24/08 ,  C30B30/00 ,  C30B30/02 ,  G01N24/00 ,  G01R33/20 ,  G01R33/46

CPC classification number: C07K1/306 ,  A61K39/39591 ,  B01J8/20 ,  B01J8/38 ,  C30B7/00 ,  C30B7/10 ,  C30B30/04 ,  G01N24/087 ,  C30B30/00 ,  C30B30/02 ,  G01N24/00 ,  G01N24/008 ,  G01R33/20 ,  G01R33/46

Abstract: Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.

公开(公告)号：US20200024363A1

公开(公告)日：2020-01-23

申请号：US16337325

申请日：2017-10-06

Applicant: AMGEN INC.

Inventor： Alona Teran ,  Qahera Muniam ,  Nazer Khalaf ,  Rahul Rajan Kaushik ,  Christi L. Clogston ,  Twinkle R. Christian ,  William J. Callahan

IPC: C07K16/40 ,  A61K9/19 ,  A61K47/22 ,  A61K47/18 ,  A61K47/24 ,  A61K47/26 ,  A61K47/42

Abstract: Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.

公开(公告)号：US20160083460A1

公开(公告)日：2016-03-24

申请号：US14832268

申请日：2015-08-21

Applicant: AMGEN INC.

Inventor： Christi L. Clogston ,  Twinkle R. Christian ,  Timothy D. Osslund ,  Elisabeth Freeman

IPC: C07K16/18

CPC classification number: C07K16/18 ,  A61K39/39591 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/56 ,  C07K2317/76

Abstract: Described herein are anti-sclerostin antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.

Abstract translation: 本文描述了抗硬化蛋白抗体结晶，制备这种抗体结晶的方法和包含抗体晶体的制剂。