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    Absorption Enhancers for Drug Administration
    11.
    发明申请
    Absorption Enhancers for Drug Administration 审中-公开
    药物管理吸收增强剂

    公开(公告)号：US20140128479A1

    公开(公告)日：2014-05-08

    申请号：US14152686

    申请日：2014-01-10

    申请人： Aegis Therapeutics, LLC.

    发明人： Edward T. Maggio

    IPC分类号： A61K47/26

    CPC分类号： A61K47/26 ,  A61K9/0043 ,  A61K9/0048 ,  A61K31/4439 ,  A61K31/70

    摘要： A composition including a surfactant and at least one alkyl glycoside and/or saccharide alkyl ester and a drug. The surfactant composition(s) when admixed with a drug is non-toxic and non-irritating, while stabilizing and increasing the bioavailability of the drug. The invention also provides compositions that enhance absorption of drugs via the oral, ocular, nasal, nasolacrimal, inhalation or pulmonary, oral cavity (sublingual or Buccal cell) or CSF delivery route of a patient, including but not limited to insulin, glucagon and exendin-4.

    摘要翻译： 包含表面活性剂和至少一种烷基糖苷和/或糖类烷基酯和药物的组合物。 当与药物混合时，表面活性剂组合物是无毒且无刺激性的，同时稳定并增加药物的生物利用度。 本发明还提供了通过口服，眼，鼻，鼻泪，吸入或肺，口腔（舌下或Buccal细胞）或CSF递送途径增加药物吸收的组合物，包括但不限于胰岛素，胰高血糖素和毒蜥外泌肽 -4。

    Compositions for Drug Administration
    12.
    发明申请
    Compositions for Drug Administration 审中-公开
    药物管理组成

    公开(公告)号：US20130253009A1

    公开(公告)日：2013-09-26

    申请号：US13893219

    申请日：2013-05-13

    申请人： Aegis Therapeutics, LLC

    发明人： Edward T. Maggio

    IPC分类号： A61K47/26

    CPC分类号： A61K47/26 ,  A61K9/0043 ,  A61K9/0048 ,  A61K31/4439 ,  A61K31/70

    摘要： The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject, as well as compositions and methods for providing migraine pain relief. The compositions include at least one alkyl glycoside and at least one therapeutic agent, such as a 5-HT receptor agonist, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms.

    摘要翻译： 本发明提供组合物和方法以及增加受试者中治疗剂的生物利用度，以及用于提供偏头痛缓解的组合物和方法。 所述组合物包括至少一种烷基糖苷和至少一种治疗剂，例如5-HT受体激动剂，其中烷基糖苷具有约10至约16个碳原子的烷基链长度。

    COMPOSITIONS FOR DRUG ADMINISTRATION
    17.
    发明申请
    COMPOSITIONS FOR DRUG ADMINISTRATION 审中-公开

    公开(公告)号：US20180169247A1

    公开(公告)日：2018-06-21

    申请号：US15890131

    申请日：2018-02-06

    申请人： Aegis Therapeutics, LLC

    发明人： Edward T. Maggio

    IPC分类号： A61K47/26 ,  A61K31/485 ,  A61K31/7016

    摘要： The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject. The compositions include at least one alkyl glycoside and at least one therapeutic agent, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms.

    Stabilizing Alkylglycoside Compositions and Methods Thereof
    19.
    发明申请
    Stabilizing Alkylglycoside Compositions and Methods Thereof 审中-公开
    稳定烷基糖苷组合物及其方法

    公开(公告)号：US20150216980A1

    公开(公告)日：2015-08-06

    申请号：US14494990

    申请日：2014-09-24

    申请人： Aegis Therapeutics, LLC

    发明人： Edward T. Maggio

    IPC分类号： A61K47/26 ,  A61K47/10 ,  A61K47/36 ,  A61K47/18 ,  A61K38/08 ,  A61K45/06

    CPC分类号： A61K38/12 ,  A61K9/0043 ,  A61K9/08 ,  A61K9/127 ,  A61K9/19 ,  A61K31/70 ,  A61K38/08 ,  A61K45/06 ,  A61K47/10 ,  A61K47/183 ,  A61K47/186 ,  A61K47/26 ,  A61K47/36

    摘要： The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or variant thereof, for example parathyroid hormone (PTH) or PTH analogs, amylin, a monoclonal antibody, insulin, Peptide T or analog thereof, gastrin, gastrin releasing peptides, gastrin releasing peptide-like (GRP) proteins, epidermal growth factor or analog thereof.

    摘要翻译： 本发明涉及含有烷基糖苷的组合物和增加其多肽，多肽或其变体（例如甲状旁腺激素（PTH））的稳定性，降低聚集和免疫原性，增加生物学活性以及减少或预防纤维状形成的方法， 或PTH类似物，胰岛淀粉样多肽，单克隆抗体，胰岛素，肽T或其类似物，胃泌素，胃泌素释放肽，胃泌素释放肽样（GRP）蛋白，表皮生长因子或其类似物。