公开(公告)号：US20210164418A1

公开(公告)日：2021-06-03

申请号：US17048243

申请日：2019-04-18

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'ORLEANS ,  UNIVERSITE D'EVRY-VAL D'ESSONNE

Inventor： Luc LEGER ,  Vladeta ZMIJANOVIC ,  Mohamed SELLAM ,  Amer CHPOUN

IPC: F02K9/97 ,  F02K9/82

Abstract: A mixing tube with multiple shapes is provided, allowing additional injection of gas in order to keep the flow detached from the second shape in an ascent phase and to bring about, in a descent phase, a controlled detachment as a result of the change of slope between the two shapes. A propulsion nozzle for an engine of a spacecraft or aircraft is provided including such a mixing tube and a method for controlling the speed transition of the propulsion gases in such a nozzle in accordance with the altitude. Also, a method is provided for vectorising the thrust in such a nozzle by radial and asymmetrical injection of gas and a control method which prevents re-attachment of the jet to the second shape of such a propulsion nozzle for an engine of a spacecraft when it is in the take-off or landing phase.

公开(公告)号：US20200289673A1

公开(公告)日：2020-09-17

申请号：US16491623

申请日：2018-03-09

Applicant: GENETHON ,  UNIVERSITE D'EVRY VAL D'ESSONNE ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE ,  SORBONNE UNIVERSITÉ

Inventor： FEDERICO MINGOZZI ,  GIUSEPPE RONZITTI ,  PATRICE VIDAL

IPC: A61K48/00 ,  A61P3/08 ,  C12N7/00 ,  C12N9/16

Abstract: The present invention relates to vectors and compositions for the treatment of glycogen storage disease III.

公开(公告)号：US20250127930A1

公开(公告)日：2025-04-24

申请号：US18991814

申请日：2024-12-23

Applicant: GENETHON ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE ,  SORBONNE UNIVERSITÉ ,  UNIVERSITE D'EVRY VAL D'ESSONNE ,  ASSOCIATION INSTITUT DE MYOLOGIE

Inventor： FEDERICO MINGOZZI ,  PASQUALINA COLELLA

IPC: A61K48/00 ,  C12N15/86

Abstract: The present invention relates to hybrid transcription regulatory elements to drive gene expression, in particular hybrid promoters, designed by the fusion of at least two transcription regulatory elements with different tissue selectivity, such as two promoters driving expression in different tissues in a tissue-selective manner.

公开(公告)号：US12171843B2

公开(公告)日：2024-12-24

申请号：US16968196

申请日：2019-02-07

Applicant: GENETHON ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE ,  SORBONNE UNIVERSITÉ ,  UNIVERSITE D'EVRY VAL D'ESSONNE ,  ASSOCIATION INSTITUT DE MYOLOGIE

Inventor： Federico Mingozzi ,  Pasqualina Colella

IPC: A61K48/00 ,  C12N15/86 ,  C12Q1/68

Abstract: The present invention relates to hybrid transcription regulatory elements to drive gene expression, in particular hybrid promoters, designed by the fusion of at least two transcription regulatory elements with different tissue selectivity, such as two promoters driving expression in different tissues in a tissue-selective manner.

公开(公告)号：US20240312008A1

公开(公告)日：2024-09-19

申请号：US18576644

申请日：2022-07-01

Applicant: UNIVERSITE D'EVRY VAL D'ESSONNE ,  CENTRE HOSPITALIER SUD FRANCILIEN

Inventor： Jonathan KOBOLD ,  Vincent VIGNERON ,  Hichem MAAREF ,  Cosmin ALECU ,  Didier SMADJA ,  Nicola CHAUSSON ,  Yann LHERMITTE

IPC: G06T7/00 ,  G06T5/40 ,  G06T7/12 ,  G06T15/00 ,  G16H30/40

CPC classification number: G06T7/0012 ,  G06T5/40 ,  G06T7/12 ,  G06T15/00 ,  G16H30/40 ,  G06T2207/10088 ,  G06T2207/20084 ,  G06T2207/30016 ,  G06T2207/30096

Abstract: A method for segmenting a thrombus and a lesion caused by the thrombus in a three-dimensional brain image, includes supervised training of a primary recurrent artificial neural network to provide a lesion prediction from an image; supervised training of a secondary recurrent artificial neural network to provide a thrombus prediction from an image; using each trained primary recurrent artificial neural network on each image of a set of images obtained from the three-dimensional image, and merging the lesion predictions obtained to obtain a set of lesion segmentations: if the set of lesion segmentations includes a segmentation, selecting the widest segmentation as the lesion segmentation; using each trained secondary recurrent artificial neural network on each image of a set of secondary images obtained from the three-dimensional image, and merging the thrombus predictions obtained to obtain a set of thrombus segmentations.

公开(公告)号：US12037362B2

公开(公告)日：2024-07-16

申请号：US16981086

申请日：2019-04-04

Applicant: Genethon ,  Institut National de la Sante et de la Recherche Medicale ,  Universite d'Evry Val d'Essonne ,  Sorbonne Universite ,  Association Institut de Myologie

Inventor： Isabelle Richard ,  Evelyne Gicquel ,  Federico Mingozzi

IPC: C07K14/005 ,  A61K48/00 ,  A61P25/28 ,  C07K14/075 ,  C12N7/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86

CPC classification number: C07K14/005 ,  A61P25/28 ,  C07K14/075 ,  C12N7/00 ,  C12N9/22 ,  C12N15/111 ,  C12N15/86 ,  A61K48/00 ,  C12N2310/20 ,  C12N2750/14121 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14152 ,  C12N2750/14171

Abstract: The invention relates to a recombinant adeno-associated virus (AAV) capsid protein, which is a hybrid between AAV serotype 9 (AAV9) and AAV serotype 74 (AAVrh74) capsid proteins, wherein said recombinant hybrid AAV capsid protein has a reduced liver tropism compared to the parent AAV9 and AAVrh74 capsid proteins. The invention relates also to the derived hybrid AAV serotype vector particles packaging a gene of interest and their use in gene therapy, in particular for treating neuromuscular genetic diseases.

公开(公告)号：US20230183651A1

公开(公告)日：2023-06-15

申请号：US17905524

申请日：2021-03-02

Applicant: ADHARA ,  CENTRE D'ETUDE DES CELLULES SOUCHES ,  UNIVERSITE D'EVRY VAL D'ESSONNE

Inventor： Christine BALDESCHI ,  Anabelle DARLE

IPC: C12N5/071

CPC classification number: C12N5/069 ,  C12N5/0698 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/727 ,  C12N2501/01 ,  C12N2506/02

Abstract: The invention relates to a method for obtaining endothelial cells from human pluripotent stem cells.

公开(公告)号：US20230151390A1

公开(公告)日：2023-05-18

申请号：US17996085

申请日：2021-04-14

Applicant: GENETHON ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITE D'EVRY VAL D'ESSONNE

Inventor： ANA BUJ BELLO ,  JÉRÔME DENARD ,  MARTINA MARINELLO

IPC: C12N15/86 ,  A61P3/00 ,  A61K38/50

CPC classification number: C12N15/86 ,  A61P3/00 ,  A61K38/50 ,  C12Y305/01023 ,  C12N2750/14143 ,  C12N2750/14171 ,  C12N2800/22 ,  C12N2830/42 ,  C12N2830/50 ,  A61K48/00

Abstract: The present invention relates to a vector comprising an ASAH1 open reading frame, for use in the treatment of acid ceramidase deficiency.

公开(公告)号：US20230119089A1

公开(公告)日：2023-04-20

申请号：US17905528

申请日：2021-03-02

Applicant: ADHARA ,  CENTRE D'ETUDE DES CELLULES SOUCHES ,  UNIVERSITE D'EVRY VAL D'ESSONNE

Inventor： Gilles LEMAITRE ,  Christine BALDESCHI ,  Sophie DOMINGUES

IPC: C12N5/077

Abstract: The invention relates to a method for differentiating human pluripotent stem cells into fibroblasts, characterized in that the human pluripotent stem cells are cultured on an adherent system in the presence of a medium that is suitable for culturing fibroblasts and in the absence of feeder cells.

公开(公告)号：US20220370640A1

公开(公告)日：2022-11-24

申请号：US17753768

申请日：2020-09-18

Applicant: GENETHON ,  UNIVERSITE D'EVRY-VAL-D'ESSONNE

Inventor： Evelyne GICQUEL ,  Isabelle RICHARD

IPC: A61K48/00 ,  A61K9/00 ,  A61P21/00

Abstract: The present invention concerns an expression system for systemic administration comprising a sequence encoding a FKRP protein, and: —a promoter sequence allowing the expression at a therapeutically acceptable level of FKRP in the skeletal muscles and a target sequence of an miRNA expressed in the heart; or—a promoter sequence allowing the expression at a therapeutically acceptable level of FKRP in the skeletal muscles and presenting a promoter activity at a toxically acceptable level in the heart; and its use for the treatment of various diseases linked to FKRP deficiencies.