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公开(公告)号：US20080167292A1
公开(公告)日：2008-07-10
申请号：US11985277
申请日：2007-11-14
IPC分类号： A61K31/55
CPC分类号： C07D487/04
摘要： The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供了极光A激酶的有效抑制剂，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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12.发明授权公开(公告)号：US06504019B2
公开(公告)日：2003-01-07
申请号：US09813644
申请日：2001-03-21
申请人： Guohan Yang , Donna M. Ford , Say-Jong Law , John E. Monahan , Todd B. Sells
发明人： Guohan Yang , Donna M. Ford , Say-Jong Law , John E. Monahan , Todd B. Sells
IPC分类号： C07H2104
摘要： Highly hydrophilic non-nucleosidic tags with multiple labels are provided for use in nucleic acid probes. The tags are branched structures having a phosphodiester backbone, which have the advantages of a small dimensional size and high hydrophilicity. After the tag is labeled, its high negative charge and minimal size help to keep the carriers away from DNA or RNA molecules, due to repulsion between negative charges. Non-specific intercalation and steric hindrance are therefore minimized, and the hydrophobicity, if any of reporter molecules is reduced. The probes are used in place of conventionally labeled oligonucleotides for a variety of hybridization reactions.
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公开(公告)号：US08809356B2
公开(公告)日：2014-08-19
申请号：US13592389
申请日：2012-08-23
IPC分类号： C07D239/47
CPC分类号： C07D239/47 , C07D239/46 , C07D473/02
摘要： Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.
摘要翻译： 公开了作为Nedd8活化酶（NAE）抑制剂的化学实体，即化合物{（1S，2S，4R）-4 - [（6 - {[（1R，2S）-5-氯-2-甲氧基 -2,3-二氢-1H-茚-1-基]氨基}嘧啶-4-基）氧基] -2-羟基环戊基}甲基氨基磺酸酯及其药学上可接受的盐; 其固态形式; 及其前体药物。 还公开了使用化学实体来治疗诸如癌症的疾病的方法。
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公开(公告)号：US08026246B2
公开(公告)日：2011-09-27
申请号：US11985277
申请日：2007-11-14
IPC分类号： A61K31/505 , C07D491/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供了极光A激酶的有效抑制剂，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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15.发明授权Pyridobenzazepine compounds and methods for inhibiting mitotic progression 有权吡啶并苯并吖嗪化合物和抑制有丝分裂进展的方法公开(公告)号：US07718648B2
公开(公告)日：2010-05-18
申请号：US11890406
申请日：2007-08-06
IPC分类号： A61P35/00 , A61K31/55 , C07D487/00
CPC分类号： C07D471/04
摘要： This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供抑制极光激酶的化合物，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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公开(公告)号：US20090299060A1
公开(公告)日：2009-12-03
申请号：US12472583
申请日：2009-05-27
申请人： Christopher F. Claiborne , Lloyd J. Payne , Richard J. Boyce , Todd B. Sells , Stephen G. Stroud , Stuart Travers , Tricia J. Vos , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Lloyd J. Payne , Richard J. Boyce , Todd B. Sells , Stephen G. Stroud , Stuart Travers , Tricia J. Vos , Gabriel S. Weatherhead
IPC分类号： C07D487/02
CPC分类号： C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D513/14
摘要： This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供抑制极光激酶的化合物，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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