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174 条记录 (耗时 0.033 秒)

    Topical Medicaments and Methods for Photodynamic Treatment of Disease
    11.
    发明申请
    Topical Medicaments and Methods for Photodynamic Treatment of Disease 有权
    光动力治疗疾病的专题药物和方法

    公开(公告)号：US20080118578A1

    公开(公告)日：2008-05-22

    申请号：US11936963

    申请日：2007-11-08

    申请人： H. Craig Dees ,  Timothy C. Scott ,  John Smolik ,  Eric A. Wachter ,  Walter G. Fisher

    发明人： H. Craig Dees ,  Timothy C. Scott ,  John Smolik ,  Eric A. Wachter ,  Walter G. Fisher

    IPC分类号： A61K33/14 ,  A61P43/00

    CPC分类号： A61K31/352 ,  A61K33/14 ,  A61K41/00 ,  A61K2300/00

    摘要： New photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene. The halogenated xanthenes constitute a family of potent photosensitizers that become photoactivated upon illumination of the treatment site with visible wavelengths of light. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs; the mouth and digestive tract and related organs; the urinary and reproductive tracts and related organs; the respiratory tract and related organs; various other internal or external tissue surfaces, such as tissue surfaces exposed during surgery; and for treatment of a variety of conditions related to microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid or aerosol delivery vehicles.

    摘要翻译： 描述了用于治疗人或动物组织的新的光动力学，局部适用药物和这种光动力药物的某些医学用途，其中这种药物的主要活性成分是卤代呫吨。 卤化呫吨构成了一系列有效的光敏剂，在用可见光波长照射治疗部位时变得光活化。 在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官的各种病症; 口腔和消化道及相关器官; 泌尿生殖道及相关器官; 呼吸道及相关器官; 各种其他内部或外部组织表面，例如在手术期间暴露的组织表面; 并用于治疗与微生物或寄生虫感染有关的各种病症。 在另一个优选的实施方案中，这种药物是以包括液体，半固体或气溶胶递送载体在内的各种制剂生产的。

    Sonar based drowning monitor
    12.
    发明授权
    Sonar based drowning monitor 失效
    基于声纳的溺水监视器

    公开(公告)号：US07330123B1

    公开(公告)日：2008-02-12

    申请号：US10865127

    申请日：2004-06-09

    申请人： Dennis A. Grahn ,  H. Craig Heller ,  Robert M. Sapolsky ,  Lisa Share

    发明人： Dennis A. Grahn ,  H. Craig Heller ,  Robert M. Sapolsky ,  Lisa Share

    IPC分类号： G08B23/00

    CPC分类号： G08B21/082

    摘要： Low-cost, reliable, easy to use device and method identifies potential drowning or near-drowning events (i.e. a submerged inert human) in a timely manner, provides the precise location of the event, and issues an alert that such an event is in progress. Device is optionally networked to remote monitoring station.

    摘要翻译： 低成本，可靠，易于使用的设备和方法及时识别潜在的溺水或近溺水事件（即淹没的惰性人），提供事件的精确位置，并发出此类事件的警报 进展。 设备可选地联网到远程监控站。

    Treatment of pigmented tissues using optical energy
    13.
    发明授权
    Treatment of pigmented tissues using optical energy 失效
    用光能处理色素组织

    公开(公告)号：US07036516B1

    公开(公告)日：2006-05-02

    申请号：US09130213

    申请日：1998-08-06

    申请人： H. Craig Dees ,  Eric A. Wachter

    发明人： H. Craig Dees ,  Eric A. Wachter

    IPC分类号： A61B19/00

    CPC分类号： A61B18/203 ,  A61B2017/00769 ,  A61B2018/00452 ,  A61B2018/00458 ,  A61B2018/0047 ,  A61B2018/00476 ,  A61N5/062

    摘要： A method and apparatus for selectively photobleaching or killing pigmented tissues by photochemically converting pigments in the tissues using light and specifically two-photon excitation. Phototoxic products thereby produced then kill pigmented cells. Hyperthermia or an exogenous agent can also be added to augment efficacy. The present invention is also directed to selective thermal destruction of pigmented tissues using related optical means.

    摘要翻译： 一种用于通过使用光和具体的双光子激发光化学转换组织中的颜料来选择性漂白或杀死有色组织的方法和装置。 由此产生的光毒产物然后杀死色素细胞。 也可以加入热疗或外源性药剂以增强功效。 本发明还涉及使用相关光学装置对着色组织的选择性热破坏。

    Methods and devices for extracting thermal energy from the body core of a mammal
    16.
    发明授权
    Methods and devices for extracting thermal energy from the body core of a mammal 有权
    用于从哺乳动物的身体核提取热能的方法和装置

    公开(公告)号：US06974442B2

    公开(公告)日：2005-12-13

    申请号：US10704345

    申请日：2003-11-06

    申请人： Dennis A. Grahn ,  H. Craig Heller

    发明人： Dennis A. Grahn ,  H. Craig Heller

    IPC分类号： A61F7/00 ,  A61F7/02 ,  A61F7/10 ,  A61H33/00

    CPC分类号： A61F7/10 ,  A61F2007/0029 ,  A61F2007/0056

    摘要： Methods and devices for extracting thermal energy from the core body of a mammal are provided. In practicing the subject methods, a portion of the mammal, e.g. a limb or portion thereof, is placed in a sealed enclosure to produce an enclosed portion of the mammal. A surface of the enclosed portion of the mammal is then contacted with a low temperature medium under negative pressure conditions for a period of time sufficient to provide for the desired core body thermal energy extraction. The subject methods and devices find use in a variety of applications, e.g. providing relief from temperature sensitive disorders, such as multiple sclerosis, and the treatment of hyperthermia, among other treatments. The subject methods and devices are particularly suited for use in enhancing the physical ability of a mammal.

    摘要翻译： 提供了用于从哺乳动物的核心体提取热能的方法和装置。 在实施本发明方法时，哺乳动物的一部分，例如， 将肢体或其部分放置在密封的外壳中以产生哺乳动物的封闭部分。 然后将哺乳动物的封闭部分的表面在负压条件下与低温培养基接触足以提供所需核心体热能提取的时间。 主题方法和装置可用于各种应用，例如， 提供诸如多发性硬化的温度敏感性疾病和治疗热疗等的缓解。 本发明的方法和装置特别适用于增强哺乳动物的身体能力。

    Rheology modification of polymers prepared using metallocenes
    18.
    发明授权
    Rheology modification of polymers prepared using metallocenes 有权
    使用金属茂制备的聚合物的流变改性

    公开(公告)号：US06528136B1

    公开(公告)日：2003-03-04

    申请号：US09140603

    申请日：1998-08-26

    申请人： Thoi H. Ho ,  Wendy D. Hoenig ,  Che-I Kao ,  Michael E. Rowland ,  Clark H. Cummins ,  Michael J. Mullins ,  H. Craig Silvis

    发明人： Thoi H. Ho ,  Wendy D. Hoenig ,  Che-I Kao ,  Michael E. Rowland ,  Clark H. Cummins ,  Michael J. Mullins ,  H. Craig Silvis

    IPC分类号： B29D2200

    CPC分类号： C08L23/02 ,  C08G81/02 ,  C08K5/43 ,  C08L23/04 ,  C08L23/06 ,  C08L23/08 ,  C08L23/0815 ,  C08L23/0838 ,  C08L23/0853 ,  C08L23/16 ,  C08L2205/22 ,  C08L2312/00 ,  C08L2314/06 ,  Y10T428/1334 ,  Y10T428/1352 ,  Y10T428/1386 ,  Y10T428/139 ,  Y10T428/31913 ,  Y10T428/31917 ,  C08L2666/04

    摘要： The invention includes a process of preparing a coupled polymer comprising heating an admixture containing (1) at least one polyolefin comprising ethylene and optionally at least one comonomer which is selected from alpha olefins having at least 3 carbon atoms, dienes and combinations thereof said polyolefin having a molecular weight distribution of less than or equal to about 3 and (2) a coupling amount at least one poly(sulfonyl azide) to at least the decomposition temperature of the poly(sulfonyl azide) for a period sufficient for decomposition of at least about 80 weight percent of the poly(sulfonyl azide) and sufficient to result in a coupled polymer; particularly where the polyolefin is the product of polymerization of ethylene and optionally at least one other alpha-olefin in the presence of a single site catalyst (transition metal like Va or Cr, metallocene or constrained geometry). The amount of poly(sulfonyl azide) is preferably from about 0.01 to about 5 weight percent of the polyolefin. The poly(sulfonyl azide)and polyolefin preferably react at a temperature at least the decomposition temperature and greater than about 150° C. The invention also includes any composition made by the process of the invention and any article made from the composition as well as processes for making the articles, particularly melt processing (especially where the article is formed from a melt of a composition of the invention), more preferably selected by molding, blow molding or extrusion blow molding the composition. The invention also includes the use of a composition of the invention in any of these processes.

    摘要翻译： 本发明包括一种制备偶联聚合物的方法，包括加热含有（1）至少一种包含乙烯和任选至少一种选自具有至少3个碳原子的α-烯烃的共聚单体的聚烯烃，二烯及其组合的混合物的混合物，所述聚烯烃具有 小于或等于约3的分子量分布和（2）偶联量至少一种聚（磺酰基叠氮化物）至少达到聚（磺酰基叠氮化物）的分解温度足够分解至少约 80重量％的聚（磺酰基叠氮化物）并且足以产生偶联的聚合物; 特别是当聚烯烃是在单中心催化剂（过渡金属如Va或Cr，金属茂或约束几何形式）存在下乙烯和任选的至少一种其它α-烯烃聚合的产物时。 聚（磺酰基叠氮化物）的量优选为聚烯烃的约0.01至约5重量％。 聚（磺酰基叠氮化物）和聚烯烃优选在至少分解温度和大于约150℃的温度下进行反应。本发明还包括通过本发明的方法制备的任何组合物和由组合物制成的任何制品以及工艺 用于制造制品，特别是熔融加工（特别是在由本发明的组合物的熔体形成制品的情况下），更优选通过模制，吹塑或挤出吹塑该组合物来选择。 本发明还包括在任何这些方法中使用本发明的组合物。