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    Method for improved selectivity in photo-activation and detection of molecular diagnostic agents
    4.
    发明授权
    Method for improved selectivity in photo-activation and detection of molecular diagnostic agents 失效
    提高光激活和分子诊断剂检测选择性的方法

    公开(公告)号：US5832931A

    公开(公告)日：1998-11-10

    申请号：US741370

    申请日：1996-10-30

    申请人： Eric A. Wachter ,  Walter G. Fisher ,  H. Craig Dees

    发明人： Eric A. Wachter ,  Walter G. Fisher ,  H. Craig Dees

    IPC分类号： G01N21/64 ,  A61B17/00 ,  A61B19/00 ,  A61K41/00 ,  A61K49/00

    CPC分类号： A61N5/062 ,  A61K41/008 ,  A61K49/0017 ,  A61K49/0039 ,  A61K49/0043 ,  A61B2017/00057 ,  B82Y15/00

    摘要： A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

    摘要翻译： 用于对特定体积的植物或动物组织进行成像的方法，其中所述植物或动物组织含有至少一种光活性分子试剂。 该方法包括以下步骤：用足以促进包含在植物或动物组织的特定体积中的光活性分子试剂的同时双光子激发的光照射植物或动物组织的特定体积，在 在植物或动物组织的特定体积中的至少一种光活性分子试剂中的至少一种，从而产生至少一种光活化分子试剂，其中至少一种光活化分子试剂发射能量，检测能量 由至少一种光活化分子试剂发射，并产生检测到的能量信号，其特征在于植物或动物组织的特定体积。 本发明也是用于对特定体积的材料进行成像的方法，其中所述材料含有至少一种光活性分子试剂。

    Method of treatment of cancer
    5.
    发明申请
    Method of treatment of cancer 审中-公开
    癌症治疗方法

    公开(公告)号：US20090117199A1

    公开(公告)日：2009-05-07

    申请号：US12315781

    申请日：2008-12-05

    申请人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    发明人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    IPC分类号： A61K33/42 ,  A61K33/14 ,  A61P35/00

    CPC分类号： A61K31/352 ,  A61K9/0019

    摘要： A method for the treatment of cancer, particularly a metastatic melanoma or a neoplastic lesion, the method comprising intralesional administration of a hydrophilic vehicle comprising 4,5,6,7-Tetrachloro-2′,4′,5′,7′-tetraiodofluorescein, or a physiologically acceptable salt thereof, at a concentration of about 0.1 w/v % up to about 20 w/v % and an electrolyte comprising at least one cation selected from the group consisting of sodium, potassium, calcium and magnesium and at least one anion selected from the group consisting of chlorine, a phosphate and a nitrate, wherein the electrolyte is at a concentration of between about 0.1 w/v % and about 2 w/v % and the pH of the solution between about 4 to about 10.

    摘要翻译： 一种治疗癌症，特别是转移性黑色素瘤或肿瘤性病变的方法，所述方法包括病灶内施用包含4,5,6,7-四氯-2'，4'，5'，7'-四碘荧光素的亲水载体 或其生理上可接受的盐，浓度为约0.1w / v％至约20w / v％，以及包含至少一种选自钠，钾，钙和镁的阳离子的电解质，并且至少 一个选自氯，磷酸盐和硝酸盐的阴离子，其中电解质的浓度为约0.1w / v％至约2w / v％，溶液的pH为约4至约10 。

    Method for improved selectivity in photo-activation of molecular agents
    6.
    发明授权
    Method for improved selectivity in photo-activation of molecular agents 失效
    提高分子试剂光激活选择性的方法

    公开(公告)号：US5998597A

    公开(公告)日：1999-12-07

    申请号：US989231

    申请日：1997-12-11

    申请人： Walter G. Fisher ,  Eric A. Wachter ,  H. Craig Dees

    发明人： Walter G. Fisher ,  Eric A. Wachter ,  H. Craig Dees

    IPC分类号： C07D487/22 ,  A61B17/00 ,  A61B19/00 ,  A61K41/00 ,  A61N5/06 ,  A61P35/00 ,  C07H21/64 ,  C07K5/00 ,  C07K14/00

    CPC分类号： A61K41/0057 ,  A61K41/008 ,  A61B2017/00057 ,  A61N5/062 ,  B82Y15/00

    摘要： A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.

    摘要翻译： 一种用于治疗特定体积的植物或动物组织的方法，包括以下步骤：用至少一种光活性分子试剂处理所述植物或动物组织，其中所述植物或动物组织的特定体积保留至少一部分 所述至少一种光活性分子试剂，然后用足以促进保留在所述至少一种光活性分子试剂中的所述至少一种光活性分子试剂中的至少一种的同时双光子激发的光来处理所述植物或动物组织的特定体积 植物或动物组织的特定体积，其中至少一种光活性分子试剂在植物或动物组织的特定体积中变得活跃。 还公开了一种用于在植物或动物组织中治疗癌症的方法以及在特定体积的材料中产生至少一种光活化分子试剂的方法。

    Medicaments for Chemotherapeutic Treatment of Disease
    8.
    发明申请
    Medicaments for Chemotherapeutic Treatment of Disease 失效
    化疗药物治疗疾病

    公开(公告)号：US20080118567A1

    公开(公告)日：2008-05-22

    申请号：US11951800

    申请日：2007-12-06

    申请人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    发明人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    IPC分类号： A61K31/352 ,  A61P35/04 ,  A61K9/14

    CPC分类号： A61K9/0019 ,  A61K31/352

    摘要： New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

    摘要翻译： 描述了新的化学治疗药物和某些医疗用途以及用于治疗人或动物组织中的这种化学治疗药物的方法，其中这种药物的主要活性成分是卤化呫吨或卤代呫吨衍生物。 优选地，卤代呫吨是玫瑰红或玫瑰红的功能衍生物。 卤代呫吨构成一系列有用的化学治疗剂，其在某些组织中提供选择性的，持续的积累。 在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官，循环系统 内脏和淋巴系统及相关器官，各种其他组织，如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。 在另一个优选的实施方案中，这些药物可用于体内或局部给药的各种制剂，包括在液体，半固体，固体或气溶胶输送载体中。

    Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents
    9.
    发明授权
    Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents 有权
    用放射性标记的卤代呫吨酶诊断剂进行正电子发射成像的方法

    公开(公告)号：US07338652B2

    公开(公告)日：2008-03-04

    申请号：US11050512

    申请日：2005-02-03

    申请人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    发明人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    IPC分类号： A61K49/04

    CPC分类号： A61K51/0421

    摘要： New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene derivative. Preferably, the radiolabeled halogenated xanthene is radiolabeled Rose Bengal or a functional derivative of Rose Bengal.

    摘要翻译： 描述了用于正电子发射断层摄影（PET）的新诊断剂和用于这种药剂用于人或动物组织成像的方法，其中这种药剂的主要活性成分是放射性标记的卤化呫吨或卤代呫吨衍生物。 优选地，放射性标记的卤代呫吨是放射性标记的玫瑰红或玫瑰红的功能衍生物。