公开(公告)号：US5318902A

公开(公告)日：1994-06-07

申请号：US948040

申请日：1992-09-21

Applicant: Edward J. St. Martin

Inventor： Edward J. St. Martin

IPC: C09B61/00 ,  C12P17/16 ,  C12P17/00 ,  C12N1/14

CPC classification number: C09B61/00 ,  C12P17/162 ,  Y10S435/911

Abstract: Several classes of water immiscible lipophilic phases effect the transfer of crystalline orange precursor pigments produced by Monascus species in an aqueous culture medium from the aqueous to the lipophilic phase without solubilizing a major portion of the pigment. Liquid vegetable and mineral oils are two such classes. This phenomenon permits high recovery of pigment in a simple and convenient manner, and also permits development of a batch recycle and a continuous fermentation process for pigment production.

Abstract translation: 几类水不混溶的亲脂相影响在水性培养基中由红曲霉属物种产生的结晶橙前体颜料从水溶液转移到亲油相，而不溶解大部分颜料。 液体植物油和矿物油是两类。 这种现象允许以简单和方便的方式高回收颜料，并且还允许开发用于颜料生产的分批循环和连续发酵方法。

公开(公告)号：US08580096B2

公开(公告)日：2013-11-12

申请号：US13248231

申请日：2011-09-29

Applicant: Edward J. St. Martin ,  YuPo J. Lin

Inventor： Edward J. St. Martin ,  YuPo J. Lin

IPC: B01D61/48

CPC classification number: C12P7/46 ,  B01D61/445 ,  B01D61/48 ,  B01D2311/2688 ,  C12M47/10

Abstract: A method for producing succinic acid is provided, which comprises circulating a fermentation broth containing succinate ion through an electrodeionization apparatus. The apparatus comprises an anode; a cathode; a stacked ion-exchange assembly comprising a one or more oriented ion-exchange units between the anode and the cathode. Each ion-exchange unit comprises a porous ion-exchange resin wafer including an inlet and an outlet together are adapted to circulate a liquid reaction stream containing a carboxylate anion from a fermentor through the resin wafer; a flow-distributing gasket for circulating a product stream through a product reservoir; an anion exchange membrane for transporting at least a portion of the carboxylate anion to the product stream; and a bipolar ion-exchange membrane to direct protons toward the cathode and into the product stream and to direct hydroxyl ions toward the anode and into the reaction stream in the resin wafer of an adjacent ion-exchange unit.

Abstract translation: 提供了一种生产琥珀酸的方法，其包括使含有琥珀酸离子的发酵液循环通过电去离子装置。 该装置包括阳极; 阴极 包括在阳极和阴极之间的一个或多个取向离子交换单元的层叠离子交换组件。 每个离子交换单元包括多孔离子交换树脂晶片，其包括入口和出口，一起适于使含有羧酸根阴离子的液体反应物流从发酵罐循环通过树脂晶片; 用于使产品流循环通过产品储存器的流量分配垫圈; 用于将至少一部分羧酸根阴离子输送到产物流的阴离子交换膜; 和双极离子交换膜，以将质子引向阴极并进入产物流，并将羟基离子引向阳极并进入相邻离子交换单元的树脂晶片中的反应流中。

公开(公告)号：US07306934B2

公开(公告)日：2007-12-11

申请号：US10702798

申请日：2003-11-05

Applicant: Michelle B. Arora ,  Jamie A. Hestekin ,  YuPo J. Lin ,  Edward J. St. Martin ,  Seth W. Snyder

Inventor： Michelle B. Arora ,  Jamie A. Hestekin ,  YuPo J. Lin ,  Edward J. St. Martin ,  Seth W. Snyder

IPC: C12N11/08 ,  C12N11/02 ,  C12P1/00 ,  C12M1/00 ,  C07K17/02 ,  C07K17/08

CPC classification number: B01D61/425 ,  B01D61/48 ,  B01J20/3265 ,  B01J47/00 ,  B01J47/018 ,  B01J47/08 ,  Y10S530/812 ,  Y10S530/815

Abstract: A porous solid ion exchange wafer having a combination of a biomolecule capture-resin and an ion-exchange resin forming a charged capture resin within said wafer. Also disclosed is a porous solid ion exchange wafer having a combination of a biomolecule capture-resin and an ion-exchange resin forming a charged capture resin within said wafer containing a biomolecule with a tag. A separate bioreactor is also disclosed incorporating the wafer described above.

Abstract translation: 具有在所述晶片内形成带电捕获树脂的生物分子捕获树脂和离子交换树脂的组合的多孔固体离子交换晶片。 还公开了具有生物分子捕获树脂和离子交换树脂的组合的多孔固体离子交换晶片，所述离子交换树脂在所述含有标签的生物分子的晶片内形成带电捕获树脂。 还公开了单独的生物反应器，其结合了上述晶片。

公开(公告)号：US06797140B2

公开(公告)日：2004-09-28

申请号：US10213721

申请日：2002-08-06

Applicant: YuPo J. Lin ,  Jamie Hestekin ,  Michelle Arora ,  Edward J. St. Martin

Inventor： YuPo J. Lin ,  Jamie Hestekin ,  Michelle Arora ,  Edward J. St. Martin

IPC: B01D6148

CPC classification number: B01D61/48 ,  B01D61/445 ,  B01J47/08 ,  C02F1/4695 ,  C02F1/66

Abstract: An electrodeionization method for continuously producing and or separating and/or concentrating ionizable organics present in dilute concentrations in an ionic solution while controlling the pH to within one to one-half pH unit method for continuously producing and or separating and/or concentrating ionizable organics present in dilute concentrations in an ionic solution while controlling the pH to within one to one-half pH unit.

Abstract translation: 一种用于连续生产和/或分离和/或浓缩离子溶液中稀释浓度的可离子化有机物的电去离子方法，同时将pH控制在用于连续生产和/或分离和/或浓缩可电离有机物的pH值单位方法中。 以离子溶液中的稀释浓度，同时将pH控制在一到一个半pH单位内。

公开(公告)号：US5567605A

公开(公告)日：1996-10-22

申请号：US342502

申请日：1994-11-21

Applicant: Edward J. St. Martin

Inventor： Edward J. St. Martin

IPC: C12Q1/32 ,  C12Q1/26 ,  G01N33/00 ,  G01N33/48

CPC classification number: C12Q1/32

Abstract: A D-allose specific dehydrogenase has been isolated which can be used with NAD as a cofactor in a sensitive, specific, quantitative assay for D-allose in aqueous media. A qualitative, color-based test for the presence of D-allose results when an election-accepting dye is coupled to NAD.

Abstract translation: 已经分离出一种D-丙氨酸特异性脱氢酶，可以在水性介质中的D-丙氨酸的灵敏，特异性，定量测定中用NAD作为辅因子。 当选择接受染料与NAD偶联时，对D-双螺旋酮的存在进行定性的基于颜色的测试。

公开(公告)号：US08007647B2

公开(公告)日：2011-08-30

申请号：US12005586

申请日：2007-12-27

Applicant: YuPo J. Lin ,  Seth W. Snyder ,  Edward J. St. Martin

Inventor： YuPo J. Lin ,  Seth W. Snyder ,  Edward J. St. Martin

IPC: B01D61/48

CPC classification number: B01D61/445 ,  B01D61/48 ,  B01J47/08 ,  C12M41/32

Abstract: A bioreactor with an anode and a cathode, and a plurality of reaction chambers each having an inlet and an outlet and each including a porous solid ion exchange wafer having ion-exchange resins. Each of the reaction chambers is interleaved between a cation exchange membrane and an anion exchange membrane or between either a cation or an anion exchange membrane and a bipolar exchange membrane. A product chamber is separated from one of the reaction chambers by either a cation or an anion exchange membrane. Recirculation mechanism is provided for transporting material between the reaction chamber inlets and outlets. A method of producing organic acids, amino acids, or amines using the separative bioreactor is disclosed.

Abstract translation: 具有阳极和阴极的生物反应器和多个具有入口和出口的反应室，每个反应室均包含具有离子交换树脂的多孔固体离子交换晶片。 每个反应室在阳离子交换膜和阴离子交换膜之间或阳离子或阴离子交换膜和双极交换膜之间交错。 通过阳离子或阴离子交换膜将产物室与一个反应室分离。 提供循环机构用于在反应室入口和出口之间输送材料。 公开了使用分离式生物反应器生产有机酸，氨基酸或胺的方法。

公开(公告)号：US20080187902A1

公开(公告)日：2008-08-07

申请号：US12005586

申请日：2007-12-27

Applicant: YuPo J. Lin ,  Seth W. Snyder ,  Edward J. St. Martin

Inventor： YuPo J. Lin ,  Seth W. Snyder ,  Edward J. St. Martin

IPC: C12Q3/00 ,  C12M1/36 ,  C12P13/04 ,  C12P7/00 ,  C12P13/00

CPC classification number: B01D61/445 ,  B01D61/48 ,  B01J47/08 ,  C12M41/32

Abstract: A bioreactor with an anode and a cathode, and a plurality of reaction chambers each having an inlet and an outlet and each including a porous solid ion exchange wafer having ion-exchange resins. Each of the reaction chambers is interleaved between a cation exchange membrane and an anion exchange membrane or between either a cation or an anion exchange membrane and a bipolar exchange membrane. A product chamber is separated from one of the reaction chambers by either a cation or an anion exchange membrane. Recirculation mechanism is provided for transporting material between the reaction chamber inlets and outlets. A method of producing organic acids, amino acids, or amines using the separative bioreactor is disclosed.

Abstract translation: 具有阳极和阴极的生物反应器和多个具有入口和出口的反应室，每个反应室均包括具有离子交换树脂的多孔固体离子交换晶片。 每个反应室在阳离子交换膜和阴离子交换膜之间或阳离子或阴离子交换膜和双极交换膜之间交错。 通过阳离子或阴离子交换膜将产物室与一个反应室分离。 提供循环机构用于在反应室入口和出口之间输送材料。 公开了使用分离式生物反应器生产有机酸，氨基酸或胺的方法。