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公开(公告)号：US09527842B2
公开(公告)日：2016-12-27
申请号：US14773223
申请日：2014-03-13
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K45/06 , C07D498/22 , C07D513/22 , A61K31/538
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/538 , A61K45/06 , C07D498/22 , C07D513/22 , C07D519/00
摘要： The disclosure generally relates to compounds of formula (I), including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
摘要翻译： 本发明一般涉及式（I）化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
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公开(公告)号：US11541055B2
公开(公告)日：2023-01-03
申请号：US16762209
申请日：2019-10-22
发明人： Eric P. Gillis , Kyle E. Parcella , Manoj Patel
IPC分类号： A61K31/517 , A61K31/496 , A61K31/4985 , A61K31/5365 , A61K9/00 , C07D403/14 , A61K31/7068
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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公开(公告)号：US20210395248A1
公开(公告)日：2021-12-23
申请号：US17287736
申请日：2019-11-04
IPC分类号： C07D471/04 , C07D519/00 , A61P31/18
摘要： Compounds of Formula I, and pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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![PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION](/abs-image/US/2021/10/21/US20210323967A1/abs.jpg.150x150.jpg)
14.发明申请公开(公告)号：US20210323967A1
公开(公告)日：2021-10-21
申请号：US17268107
申请日：2020-06-17
发明人： Eric P. GILLIS , Christiana IWUAGWU
IPC分类号： C07D487/04 , A61K45/06 , A61P31/18 , A61K9/00
摘要： The compound and pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth.
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公开(公告)号：US20210214345A1
公开(公告)日：2021-07-15
申请号：US17263272
申请日：2019-08-07
发明人： Makonen BELEMA , Manoj PATEL
IPC分类号： C07D403/14 , A61K31/513
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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![5-(n-[6,5]-fused bicyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication](/abs-image/US/2020/03/03/US10577353B2/abs.jpg.150x150.jpg)
公开(公告)号：US10577353B2
公开(公告)日：2020-03-03
申请号：US15749144
申请日：2016-08-10
发明人： John F. Kadow , B. Narasimhulu Naidu , Tao Wang , Zhiwei Yin , Zhongxing Zhang
IPC分类号： C07D401/14 , C07D403/14 , C07D473/16 , C07D471/04 , C07D513/04 , C07D487/04 , C07D495/04 , C07D417/14 , C07D473/18 , A61K31/4427 , A61P31/18 , A61K31/5365
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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17.发明授权公开(公告)号：US10407410B2
公开(公告)日：2019-09-10
申请号：US16094536
申请日：2017-05-09
发明人： John F. Kadow , B. Narasimhulu Naidu , Manoj Patel , Michael A. Walker , Tao Wang , Zhiwei Yin , Zhongxing Zhang , Zhizhen Barbara Zheng
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D407/14 , C07D409/14 , C07D417/14 , A61P31/18 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5365 , C07D411/14
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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18.发明授权公开(公告)号：US10125148B2
公开(公告)日：2018-11-13
申请号：US15119475
申请日：2014-02-19
发明人： Timothy P. Connolly , Stanley D'Andrea , John F. Kadow , David R. Langley , B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Michael A. Walker , Zhongyu Wang , Zhizhen Barbara Zheng
IPC分类号： C07D498/16 , C07D498/22 , A61K31/519 , A61K45/06
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US09938271B2
公开(公告)日：2018-04-10
申请号：US15119465
申请日：2015-02-13
IPC分类号： C07D471/04 , C07D498/22
CPC分类号： C07D471/04 , C07D498/22
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US09914747B2
公开(公告)日：2018-03-13
申请号：US15521957
申请日：2015-11-12
发明人： Jie Chen , Yan Chen , Nicholas A. Meanwell , Alicia Regueiro-Ren , Sing-Yuen Sit , Jacob Swidorski
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I and II: These compounds are useful for the treatment of HIV and AIDS.
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