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公开(公告)号：USRE46425E1
公开(公告)日：2017-06-06
申请号：US14734785
申请日：2015-06-09
发明人： Laura L. Eggink , J. Kenneth Hoober
摘要： This present invention is directed to peptides, compositions, and methods for modulating endogenous cytokine expression in a subject. More specifically, the invention provides peptides useful in regulating the release of a specific pattern of cytokines that promote angiogenesis and/or can be used to modulate the immune system of a subject.
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公开(公告)号：US07811995B2
公开(公告)日：2010-10-12
申请号：US11955226
申请日：2007-12-12
申请人： Laura L. Eggink , Kenneth J. Hoober
发明人： Laura L. Eggink , Kenneth J. Hoober
CPC分类号： C07K7/06 , A61K38/00 , C07K14/001
摘要： This invention generally relates to peptides useful for medical diagnosis and treatment of pathogenic disorders. More specifically, the invention relates to immunostimulatory peptides which can stimulate the production of therapeutically beneficial cytokines and, in combination with antibodies against human pathogens such as the immunodeficiency virus (HIV), inhibit replication of such pathogens. The peptides interact synergistically with pathogen-directed antibodies without producing or sustaining serious side-effects such as inflammation, and provide the potential for treatment modalities that are non-specific with respect to pathogen and cell type. Therefore, the peptides of the present invention have wide applicability with respect to medical treatment of pathogen-mediated infections, and the potential to enhance well-being.
摘要翻译： 本发明一般涉及可用于医学诊断和治疗病原性疾病的肽。 更具体地，本发明涉及可以刺激产生治疗有益的细胞因子的免疫刺激肽，并且与针对人类病原体（例如免疫缺陷病毒（HIV））的抗体结合抑制这种病原体的复制。 肽与病原体定向的抗体协同作用而不产生或维持诸如炎症的严重副作用，并且提供了关于病原体和细胞类型非特异性的治疗方式的潜力。 因此，本发明的肽在病原体介导的感染的医疗上具有广泛的适用性，并且具有增强健康的潜力。
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公开(公告)号：US11376307B2
公开(公告)日：2022-07-05
申请号：US16960267
申请日：2019-01-03
发明人： Laura L. Eggink , J. Kenneth Hoober
摘要： The present disclosure relates to pharmaceutical compositions comprising a peptide or multivalent polypeptide, and an anti-cancer agent. In some embodiments, the anti-cancer agent is conjugated to the peptide or multivalent polypeptide. The present disclosure also relates to a method of treating cancer or reducing cancer cell proliferation using the peptide or multivalent polypeptide. In some aspects, the peptide or multivalent polypeptide enhances the efficacy of the anti-cancer agent, the targeting of the anti-cancer agent to the cancer cells, or both.
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公开(公告)号：US10093712B2
公开(公告)日：2018-10-09
申请号：US13270010
申请日：2011-10-10
申请人： Laura L. Eggink , Valerie Jacobs , Kenneth Hoober
发明人： Laura L. Eggink , Valerie Jacobs , Kenneth Hoober
IPC分类号： C07K14/57
摘要： The present invention provides novel immune-stimulatory polypeptides, and methods for their use and identification.
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15.发明申请COMPOSITIONS AND METHODS FOR MODULATING INNATE AND ADAPTIVE IMMUNE SYSTEMS 审中-公开用于调节静止和自适应免疫系统的组合物和方法公开(公告)号：US20150299252A1
公开(公告)日：2015-10-22
申请号：US14101334
申请日：2013-12-09
发明人： Laura L. Eggink , J. Kenneth Hoober
IPC分类号： C07K7/06 , A61K39/395 , A61K45/06 , A61K39/00
CPC分类号： C07K7/06 , A61K39/00 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： Compositions and methods useful in modulating the innate and adaptive immune systems in a subject, including activation of natural killer (NK) cells and/or CD8+ cytotoxic T lymphocytes. The method typically comprises: administering to the subject a composition comprising a therapeutic peptide or a multivalent structured polypeptide comprising multiple copies of the therapeutic peptide described herein in an amount sufficient to increase activity of NK cells and/or CD8+ cytotoxic T lymphocytes in the subject. Preferred therapeutic compositions comprise a carrier; at least one agent selected from the group consisting of: an anti-inflammatory agent, a cytotoxic T cell proliferation agent, or a NK cell proliferation agent; and a therapeutic peptide or a multivalent structured polypeptides of the invention. In certain embodiments, the composition further comprises an immunoglobulin admixed therewith in an amount sufficient to enhance passive immunoprotection in the subject. In other embodiments, the compositions are administered in a therapeutically effective amount to a subject in need thereof to treat rheumatoid arthritis.
摘要翻译： 用于调节受试者的先天和适应性免疫系统的组合物和方法，包括激活天然杀伤（NK）细胞和/或CD8 +细胞毒性T淋巴细胞。 该方法通常包括：向受试者施用包含治疗肽或多价结构化多肽的组合物，其包含本文所述治疗肽的多个拷贝，其量足以增加受试者中NK细胞和/或CD8 +细胞毒性T淋巴细胞的活性。 优选的治疗组合物包含载体; 至少一种选自抗炎剂，细胞毒性T细胞增殖剂或NK细胞增殖剂的药剂; 和本发明的治疗肽或多价结构多肽。 在某些实施方案中，组合物还包含与其混合的免疫球蛋白，其量足以增强受试者的被动免疫保护。 在其它实施方案中，组合物以治疗有效量施用于有需要的受试者以治疗类风湿性关节炎。
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公开(公告)号：US08496942B2
公开(公告)日：2013-07-30
申请号：US12823560
申请日：2010-06-25
申请人： Laura L. Eggink , J. Kenneth Hoober
发明人： Laura L. Eggink , J. Kenneth Hoober
CPC分类号： C07K14/001 , A61K38/00 , C07K5/1008 , C07K5/1013 , C07K7/06
摘要： The present invention is directed to a family of therapeutic peptides capable of modulating cytokine expression and/or stimulating the immune system of subject without producing or sustaining serious side-effects. Methods using the peptides to modulate cytokine expression in a subject, treat a disease, enhance vaccination, and stimulate a subject's immune system response are also disclosed.
摘要翻译： 本发明涉及能够调节细胞因子表达和/或刺激受试者的免疫系统的一系列治疗性肽，而不产生或维持严重的副作用。 还公开了使用肽来调节受试者中的细胞因子表达，治疗疾病，增强免疫接种和刺激受试者的免疫系统应答的方法。
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公开(公告)号：US07838497B2
公开(公告)日：2010-11-23
申请号：US11955143
申请日：2007-12-12
申请人： Laura L. Eggink , J. Kenneth Hoober
发明人： Laura L. Eggink , J. Kenneth Hoober
摘要： This present invention generally relates to peptides, compositions, treatment methods, and devices useful for the medical diagnosis and treatment of pathogenic disorders. More specifically, the invention relates to immunostimulatory peptides which can stimulate the production of therapeutically beneficial cytokines. The peptides of the invention can regulate the release of a specific pattern of cytokines that promote angiogenesis, and modulate the immune system of a subject, without inducing deleterious side effects such as inflammation. Therefore, the peptides have therapeutic importance, particularly with respect to wound healing and restoration of circulation to damaged tissues.
摘要翻译： 本发明一般涉及可用于医学诊断和治疗病原性疾病的肽，组合物，治疗方法和装置。 更具体地，本发明涉及可以刺激产生治疗有益的细胞因子的免疫刺激肽。 本发明的肽可以调节促进血管生成的细胞因子的特定模式的释放，并且调节受试者的免疫系统，而不会引起有害的副作用如炎症。 因此，肽具有治疗重要性，特别是在伤口愈合和对受损组织的循环恢复方面。
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公开(公告)号：US20080292650A1
公开(公告)日：2008-11-27
申请号：US11955226
申请日：2007-12-12
申请人： Laura L. Eggink , J. Kenneth Hoober
发明人： Laura L. Eggink , J. Kenneth Hoober
CPC分类号： C07K7/06 , A61K38/00 , C07K14/001
摘要： This invention generally relates to peptides useful for medical diagnosis and treatment of pathogenic disorders. More specifically, the invention relates to immunostimulatory peptides which can stimulate the production of therapeutically beneficial cytokines and, in combination with antibodies against human pathogens such as the immunodeficiency virus (HIV), inhibit replication of such pathogens. The peptides interact synergistically with pathogen-directed antibodies without producing or sustaining serious side-effects such as inflammation, and provide the potential for treatment modalities that are non-specific with respect to pathogen and cell type. Therefore, the peptides of the present invention have wide applicability with respect to medical treatment of pathogen-mediated infections, and the potential to enhance well-being.
摘要翻译： 本发明一般涉及可用于医学诊断和治疗病原性疾病的肽。 更具体地，本发明涉及可以刺激产生治疗有益的细胞因子的免疫刺激肽，并且与针对人类病原体（例如免疫缺陷病毒（HIV））的抗体结合抑制这种病原体的复制。 肽与病原体定向的抗体协同作用而不产生或维持诸如炎症的严重副作用，并且提供了关于病原体和细胞类型非特异性的治疗方式的潜力。 因此，本发明的肽在病原体介导的感染的医疗上具有广泛的适用性，并且具有增强健康的潜力。
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公开(公告)号：US20080233081A1
公开(公告)日：2008-09-25
申请号：US11955143
申请日：2007-12-12
申请人： Laura L. Eggink , J. Kenneth Hoober
发明人： Laura L. Eggink , J. Kenneth Hoober
摘要： This present invention generally relates to peptides, compositions, treatment methods, and devices useful for the medical diagnosis and treatment of pathogenic disorders. More specifically, the invention relates to immunostimulatory peptides which can stimulate the production of therapeutically beneficial cytokines. The peptides of the invention can regulate the release of a specific pattern of cytokines that promote angiogenesis, and modulate the immune system of a subject, without inducing deleterious side effects such as inflammation. Therefore, the peptides have therapeutic importance, particularly with respect to wound healing and restoration of circulation to damaged tissues.
摘要翻译： 本发明一般涉及可用于医学诊断和治疗病原性疾病的肽，组合物，治疗方法和装置。 更具体地，本发明涉及可以刺激产生治疗有益的细胞因子的免疫刺激肽。 本发明的肽可以调节促进血管生成的细胞因子的特定模式的释放，并且调节受试者的免疫系统，而不会引起有害的副作用如炎症。 因此，肽具有治疗重要性，特别是在伤口愈合和对受损组织的循环恢复方面。
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