公开(公告)号：US20060200206A1

公开(公告)日：2006-09-07

申请号：US11355038

申请日：2006-02-15

Applicant: Andrew Firlik ,  Jeffrey Balzer ,  Bradford Gliner ,  Alan Levy ,  Carlton Morgan

Inventor： Andrew Firlik ,  Jeffrey Balzer ,  Bradford Gliner ,  Alan Levy ,  Carlton Morgan

IPC: A61N1/34

CPC classification number: A61N1/375 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

公开(公告)号：US07010351B2

公开(公告)日：2006-03-07

申请号：US09802808

申请日：2001-03-08

Applicant: Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford E. Gliner ,  Alan J. Levy ,  Carlton B. Morgan

Inventor： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford E. Gliner ,  Alan J. Levy ,  Carlton B. Morgan

IPC: A61N1/18

CPC classification number: A61N1/375 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

公开(公告)号：US06990377B2

公开(公告)日：2006-01-24

申请号：US10832477

申请日：2004-04-26

Applicant: Bradford E. Gliner ,  Warren D. Sheffield

Inventor： Bradford E. Gliner ,  Warren D. Sheffield

IPC: A61N1/10

CPC classification number: A61N1/36046 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36103

Abstract: System and methods for effectuating and/or facilitating visual function in a patient. One embodiment of a system comprises a neural stimulation system and a visual training system. The neural stimulation system can include a pulse generator and a stimulus delivery device coupled to the pulse generator. The stimulus delivery device is configured to deliver a stimulus to the brain of the patient. The visual training system can include a computer and a display coupled to the computer. The computer has a computer operable medium containing instructions to provide a visual output to the patient via the display.

Abstract translation: 用于实现和/或促进患者视觉功能的系统和方法。 系统的一个实施例包括神经刺激系统和视觉训练系统。 神经刺激系统可以包括脉冲发生器和耦合到脉冲发生器的刺激输送装置。 刺激递送装置被配置成向患者的大脑递送刺激。 视觉训练系统可以包括计算机和耦合到计算机的显示器。 计算机具有计算机可操作介质，其包含经由显示器向患者提供视觉输出的指令。

公开(公告)号：US20050283201A1

公开(公告)日：2005-12-22

申请号：US11121056

申请日：2005-05-04

Applicant: Andre Machado ,  Ali Rezai

Inventor： Andre Machado ,  Ali Rezai

IPC: A61N1/05 ,  A61N1/18 ,  A61N1/36

CPC classification number: A61N1/36103 ,  A61N1/36067 ,  A61N1/36075 ,  A61N1/36082

Abstract: Methods of treating various medical conditions by neuromodulation of a target site of interhemispheric fibers. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, hereditary/genetic disorders, congenital malformations, infection disease, degenerative disorder, autoimmune disorders, and metabolic disorders. A method of providing recovery and rehabilitation from states of reduced consciousness by neuromodulating a target site of interhemispheric fibers is also provided.

Abstract translation: 通过神经调节大脑半球纤维目标部位治疗各种疾病的方法。 这种医疗状况包括单侧运动障碍，运动障碍，精神障碍，与半球病变相关的言语或认知缺陷，与半球病变相关的视力缺陷，遗传性/遗传性疾病，先天性畸形，感染疾病，退行性疾病，自身免疫性疾病和代谢性疾病 。 还提供了一种通过神经调节大脑半球纤维的目标部位来提供恢复和恢复的意识降低的方法。

公开(公告)号：US20050004624A1

公开(公告)日：2005-01-06

申请号：US10832477

申请日：2004-04-26

Applicant: Bradford Gliner ,  Warren Sheffield

Inventor： Bradford Gliner ,  Warren Sheffield

IPC: A61F20060101 ,  A61N1/08 ,  A61N1/10 ,  A61N1/18 ,  A61N1/20 ,  A61N1/32 ,  A61N1/34 ,  A61N1/36 ,  A61N1/40

CPC classification number: A61N1/36046 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36103

Abstract: System and methods for effectuating and/or facilitating visual function in a patient. One embodiment of a system comprises a neural stimulation system and a visual training system. The neural stimulation system can include a pulse generator and a stimulus delivery device coupled to the pulse generator. The stimulus delivery device is configured to deliver a stimulus to the brain of the patient. The visual training system can include a computer and a display coupled to the computer. The computer has a computer operable medium containing instructions to provide a visual output to the patient via the display.

Abstract translation: 用于实现和/或促进患者视觉功能的系统和方法。 系统的一个实施例包括神经刺激系统和视觉训练系统。 神经刺激系统可以包括脉冲发生器和耦合到脉冲发生器的刺激输送装置。 刺激递送装置被配置成向患者的大脑递送刺激。 视觉训练系统可以包括计算机和耦合到计算机的显示器。 计算机具有计算机可操作介质，其包含经由显示器向患者提供视觉输出的指令。

公开(公告)号：US20030088274A1

公开(公告)日：2003-05-08

申请号：US10261116

申请日：2002-09-30

Applicant: Vertis Neuroscience, Inc.

Inventor： Bradford Evan Gliner ,  Alan J. Levy ,  Jeffrey Blazer ,  Andrew D. Firlik ,  W. Douglas Sheffield

IPC: A61N001/18

CPC classification number: A61N1/36103 ,  A61N1/36017 ,  A61N1/3756 ,  C12N13/00

Abstract: The following disclosure describes several methods and apparatus for stimulating cells implanted in the regions of nervous system, such as the brain, spinal cord or peripheral nerves. Accordingly, the functionality of the cells can be improved, for example, by differentiating undifferentiated or partially undifferentiated cells into neurons or other cells having action potentials. The method can also include promoting directional growth and connectivity of fully differentiated neural cells implanted in a patient's nervous system through electrical enhancement, for example, electrical stimulation via an anode and cathode. Methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).

Abstract translation: 以下公开内容描述了用于刺激植入神经系统诸如脑，脊髓或周围神经的区域中的细胞的几种方法和装置。 因此，可以通过例如将未分化或部分未分化的细胞分化成具有动作电位的神经元或其他细胞来改善细胞的功能。 该方法还可以包括通过电增强（例如经由阳极和阴极的电刺激）促进植入患者神经系统中的完全分化的神经细胞的定向生长和连通性。 根据本发明的方法可用于治疗脑损伤（例如中风，创伤等），脑疾病（例如，阿尔茨海默氏症，皮克病，帕金森病等）和/或脑部疾病（例如，癫痫，抑郁症 等）。 根据本发明的方法还可以用于增强正常，健康的大脑（例如学习，记忆等）的神经功能，或用于控制感觉功能（例如疼痛）。

公开(公告)号：US20020120309A1

公开(公告)日：2002-08-29

申请号：US10022562

申请日：2001-12-12

Inventor： Frances J.R. Richmond ,  Gerald E. Loeb ,  Tessa Gordon

IPC: A61N001/18

CPC classification number: A61N1/36103 ,  A61N1/36146 ,  A61N1/37205

Abstract: Recovery from peripheral nerve and nerve plexus injuries is usually slow and incomplete because the regenerating motor axons often head erroneously toward sensory receptors rather than muscle fibers and because the target muscles atrophy while waiting for the slow process of reinnervation. Research has suggested that electrical stimulation with different waveforms and temporal patterns at different times during the regeneration process might improve the clinical outcome through various mechanisms, but a practical means to deliver such stimulation has been lacking. This invention teaches the use of miniature electrical stimulators that can be implanted alongside the injured nerve(s) at the time of surgical repair and that can be powered and controlled by transmission of radiofrequency energy from outside the body so as to provide a variety of electrical stimuli at different times during the recovery process.

Abstract translation: 从周围神经和神经丛损伤的恢复通常是缓慢和不完整的，因为再生运动轴突通常头错误地朝向感觉受体而不是肌肉纤维，并且因为目标肌肉萎缩同时等待缓慢的再狭窄过程。 研究表明，再生过程中不同波形和不同时期的电刺激可能会通过各种机制改善临床结果，但是缺乏实现这种刺激的实用手段。 本发明教导了使用微型电刺激器，其可以在手术修复时被植入在受伤的神经旁边，并且可以通过从身体外部传输射频能量来供电和控制，以便提供各种电气 刺激在恢复过程中的不同时间。

公开(公告)号：US5611350A

公开(公告)日：1997-03-18

申请号：US598376

申请日：1996-02-08

Applicant: Michael S. John

Inventor： Michael S. John

IPC: A61B5/0484 ,  A61N1/36

CPC classification number: A61N1/3605 ,  A61B5/0484 ,  A61N1/36082 ,  A61N1/36103

Abstract: In a medical procedure to treat a patient in a deep coma, an electrode is implanted on the vagus nerve (tenth cranial nerve) in the patient's neck. A selected pulse train is generated and applied to the electrode as a treatment for the deep coma. The patient's brain waves are collected, amplified and digitized before, during and after the treatment, and compared, using a computer system, against a reference (the patient or/and a normal group) to determine if the treatment is helping the patient.

Abstract translation: 在治疗深昏迷患者的医疗过程中，将电极植入患者颈部的迷走神经（第十脑神经）上。 产生选择的脉冲串并将其施加到电极作为深昏迷的治疗。 在治疗之前，期间和之后收集，放大和数字化患者的脑波，并使用计算机系统与参考（患者或/和正常组）比较以确定治疗是否帮助患者。

公开(公告)号：US4919140A

公开(公告)日：1990-04-24

申请号：US258142

申请日：1988-10-14

Applicant: Richard B. Borgens ,  Michael E. McGinnis

Inventor： Richard B. Borgens ,  Michael E. McGinnis

IPC: A61N1/36

CPC classification number: A61N1/36103 ,  A61N1/0553 ,  A61N1/326

Abstract: A method and apparatus for stimulating nerves in the central nervous system of a mammal to regenerate within the central nervous system applies an oscillating electrical field to the central nervous system across a lesion in the central nervous system. The polarity reversal period of the electrical field is long enough to stimulate growth of cathodally facing axons of the nerve cells in the central nervous system but is shorter than a die back period of anodally facing axons of the nerve cells.

Abstract translation: 用于刺激哺乳动物的中枢神经系统中的神经在中枢神经系统内再生的方法和装置通过中枢神经系统的损伤向中枢神经系统施加振荡电场。 电场的极性反转时间足够长以刺激中枢神经系统中神经细胞的阴极面向的轴突的生长，但是比神经细胞的阳极面向轴突的死亡期短。

公开(公告)号：US20240293673A1

公开(公告)日：2024-09-05

申请号：US18117299

申请日：2023-03-03

Applicant: Cortigent, Inc.

Inventor： Proyag Datta ,  Jerry Ok ,  Uday Patel

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/378

CPC classification number: A61N1/36103 ,  A61N1/0531 ,  A61N1/36139 ,  A61N1/3787

Abstract: Briefly, and in general terms, the present invention is directed to a cortical stimulator for neuromodulation. The cortical stimulator is configured so as to stimulate or block the operation of a portion of the cortex, for example, but not limited to, the motor cortex of a subject who has suffered a stroke. The present disclosure of a cortical stimulator includes a flexible circuit electrode array connected to an electronics package and a coil inductively coupled to an external coil for power and data. The present invention includes an electrode array significantly larger than the area intended to be stimulated. The larger electrode array allows a clinician to select the location of stimulation after completion of the surgery.