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公开(公告)号：US20030108989A1
公开(公告)日：2003-06-12
申请号：US10177485
申请日：2002-06-20
Applicant: Genentech, Inc.
Inventor： Napoleone Ferrara , David Wai-Hung Leung
IPC: C07K014/475 , C12P021/02 , C07H021/04
Abstract: DNA isolates coding for a vascular endothelial cell growth factor may be used to produce the protein via recombinant expression systems. Such protein is useful therapeutically to treat conditions in which a selective action on the vascular endothelial cells, in the absence of excessive connective tissue proliferation, is desirable.
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162.发明申请公开(公告)号：US20030105013A1
公开(公告)日：2003-06-05
申请号：US10223090
申请日：2002-08-16
Applicant: Genentech, Inc.
Inventor： Kevin P. Baker , Napoleone Ferrara , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , Scot A. Marsters , James Pan , Jean-Philippe F. Stephan , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Weilan Ye
IPC: A61K038/17 , C12P021/02 , C12N005/06 , C07K014/435 , C07H021/04 , C12N009/00
CPC classification number: A61K38/17 , C07H21/04 , C07K14/435 , C07K14/47 , C12N5/06 , C12N9/00 , C12P21/02
Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20030104469A1
公开(公告)日：2003-06-05
申请号：US09907652
申请日：2001-07-17
Applicant: Genentech, Inc.
Inventor： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Niclolas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC: G01N033/53 , C12N009/00 , C07H021/04 , C12P021/02 , C12N005/06 , C07K014/435 , C07K016/40
CPC classification number: C07K14/47 , G01N33/68 , G01N2333/485
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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164.发明申请Production of vascular endothelial cell growth factor and DNA encoding same 失效生产血管内皮细胞生长因子和编码DNA的DNA公开(公告)号：US20030100072A1
公开(公告)日：2003-05-29
申请号：US10150046
申请日：2002-05-17
Applicant: Genentech, Inc.
Inventor： Napoleone Ferrara , David Wai-Hung Leung
IPC: C07H021/04 , C12P021/02 , C12N005/06 , C07K014/515
Abstract: DNA isolates coding for a vascular endothelial cell growth factor may be used to produce the protein via recombinant expression systems. Such protein is useful therapeutically to treat conditions in which a selective action on the vascular endothelial cells, in the absence of excessive connective tissue proliferation, is desirable.
Abstract translation: 编码血管内皮细胞生长因子的DNA分离物可用于通过重组表达系统产生蛋白质。 这种蛋白质在治疗上可用于治疗在不需要过度结缔组织增殖的情况下对血管内皮细胞的选择性作用的条件。
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公开(公告)号：US20030099625A1
公开(公告)日：2003-05-29
申请号：US10015386
申请日：2001-12-12
Applicant: Genentech, Inc.
Inventor： Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
IPC: G01N033/53 , C07H021/04 , A61K038/43 , C12N009/00 , C12P021/02 , C12N005/06 , C07K014/435 , C07K016/40
CPC classification number: C07K14/47 , C07K14/705
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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Patent Agency Ranking
公开(公告)号：US20030096744A1
公开(公告)日：2003-05-22
申请号：US09978187
申请日：2002-01-28
Applicant: Genentech, Inc.
Inventor： Avi J. Ashkenazi , Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Sophia S. Kuo , Mary A. Napier , James Pan , Nicholas F. Paoni , Margaret Ann Roy , David L. Shelton , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC: A61K038/17 , C12P021/02 , C12N005/06 , C07K014/435 , C07H021/04 , C12N009/00
CPC classification number: C07K14/47 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/4703 , C07K14/475 , C07K14/52 , C07K14/521 , C07K14/54 , C07K14/705 , C07K14/70503 , C07K14/70578 , C07K16/18 , C07K16/28 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N9/00 , C12N2799/026 , C12N2799/027 , G01N33/573 , G01N33/57484 , G01N33/68 , G01N2333/99 , G01N2800/042
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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167.发明申请Production of vascular endothelial cell growth factor and DNA enconding same 审中-公开生产血管内皮细胞生长因子和DNA包裹相同公开(公告)号：US20030092617A1
公开(公告)日：2003-05-15
申请号：US10166941
申请日：2002-06-10
Applicant: Genentech, Inc.
Inventor： Napoleone Ferrara , David Wai-Hung Leung
IPC: A61K038/18
Abstract: DNA isolates coding for a vascular endothelial cell growth factor may be used to produce the protein via recombinant expression systems. Such protein is useful therapeutically to treat conditions in which a selective action on the vascular endothelial cells, in the absence of excessive connective tissue proliferation, is desirable.
Abstract translation: 编码血管内皮细胞生长因子的DNA分离物可用于通过重组表达系统产生蛋白质。 这种蛋白质在治疗上可用于治疗在不需要过度结缔组织增殖的情况下对血管内皮细胞的选择性作用的条件。
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公开(公告)号：US20030087305A1
公开(公告)日：2003-05-08
申请号：US09997384
申请日：2001-11-15
Applicant: Genentech, Inc.
Inventor： Avi J. Ashkenazi , Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Ivar J. Kljavin , Mary A. Napier , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Zemin Zhang
IPC: G01N033/53 , C07H021/04 , C12N009/00 , A61K038/17 , C12P021/02 , C12N005/06 , C07K014/435 , C07K016/40
CPC classification number: C07K14/47 , A61K38/00 , A61K39/00 , C07K14/52 , C07K14/705 , C07K16/18 , C07K2319/00 , C12N9/00 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/57484 , G01N33/68 , G01N33/6842 , Y10S530/866
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20030082628A1
公开(公告)日：2003-05-01
申请号：US10017527
申请日：2001-12-13
Applicant: Genentech, Inc.
Inventor： Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
IPC: G01N033/53 , A61K038/17 , C07H021/04 , C12N009/00 , C12N005/06 , C12P021/02 , C07K014/435 , C07K016/40
CPC classification number: C07K14/47 , C07K14/705
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20030082540A1
公开(公告)日：2003-05-01
申请号：US09902634
申请日：2001-07-10
Applicant: Genentech, Inc.
Inventor： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC: C12Q001/68 , G01N033/53 , C07H021/04 , C12N009/00 , C12P021/02 , C12N005/06 , C07K014/435
CPC classification number: C07K14/47 , G01N33/68 , G01N2333/485
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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