公开(公告)号：US20210062192A1

公开(公告)日：2021-03-04

申请号：US16771789

申请日：2018-12-07

Applicant: Bayer Animal Health GmbH

Inventor： Thomas ILG

IPC: C12N15/117 ,  A61K39/39 ,  A61P37/04

Abstract: Disclosed herein are immunostimulatory oligonucleotides and compositions and methods of use thereof. More specifically, immunostimulatory oligonucleotides, methods of optimizing the immunostimulatory properties of oligonucleotides, and methods of using the immunostimulatory oligonucleotides to elicit a toll-like receptor 21 (TLR21)-mediated immune response are disclosed.

公开(公告)号：US10934550B2

公开(公告)日：2021-03-02

申请号：US15100536

申请日：2014-12-02

Applicant: Phio Pharmaceuticals Corp.

Inventor： Alexey Wolfson ,  Alexey Eliseev ,  Taisia Shmushkovich

IPC: C07H21/04 ,  C12N15/117 ,  A61K39/00 ,  C12N15/113

Abstract: Immunogenic modulators and compositions comprising oligonucleotide agents capable of inhibiting suppression of immune response by reducing expression of one or more gene involved with an immune suppression mechanism.

公开(公告)号：US10894963B2

公开(公告)日：2021-01-19

申请号：US14907430

申请日：2014-07-25

Applicant: Exicure, Inc.

Inventor： Aleksandar Filip Radovic-Moreno ,  Christopher C. Mader ,  Subbarao Nallagatla ,  Warefta Hasan ,  Aaron Love ,  Sergei Gryaznov

IPC: C12N15/117 ,  A61K39/39 ,  B82Y5/00 ,  A61K39/00

Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof. The compositions of the invention are useful for activating agonists of nucleic acid interacting complexes, such as TLRs, stimulating an immune response, and treating diseases such as infectious disease, cancer, allergies, allergic diseases, and autoimmune disease

公开(公告)号：US20210010003A1

公开(公告)日：2021-01-14

申请号：US16793334

申请日：2020-02-18

Applicant: Mologen AG

Inventor： Matthias Schroff ,  Manuel Schmidt ,  Kerstin Kapp ,  Alfredo Zurlo

IPC: C12N15/117 ,  C12N15/11 ,  C07K16/30 ,  C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61K31/7088

Abstract: The invention relates to a combination and its use for the treatment of diseases. The instant disclosure provides a combination of a so-called T-cell regulator selected from the group comprising PD1, PD-L1, OX40, TIM-3, LAG3, CD137(4-1BB) and a non-coding immunomodulating DNA.

公开(公告)号：US10813987B2

公开(公告)日：2020-10-27

申请号：US14346706

申请日：2012-09-21

Applicant: Loma Linda University

Inventor： Alan P. Escher

IPC: A61K39/00 ,  A61K39/02 ,  C12N9/10 ,  C12N15/70 ,  C12N9/50 ,  C12N9/22 ,  C12N15/117 ,  A61K49/00

Abstract: The subject technology relates generally to compositions and methods for producing plasmid DNA of a desired quality. In addition, it relates to the discovery of Escherichia coli (E. coli) bacteria with a constitutive methylase gene stably incorporated into the chromosomal DNA and uses thereof.

公开(公告)号：US10752902B2

公开(公告)日：2020-08-25

申请号：US15513660

申请日：2015-09-22

Applicant: Board of Trustees of Michigan State University

Inventor： Andrea Amalfitano ,  Yasser A. Aldhamen

IPC: C07K19/00 ,  C07K14/47 ,  C12N15/117 ,  C07K14/705 ,  A61K38/02 ,  A61K38/17 ,  A61K39/00

Abstract: The disclosure relates to, among other things, agents that modulate the homophilic interaction between two CRACC polypeptides, methods for making such agents, and therapeutic applications in which the agents are useful. For example, the agents described herein are useful for modulating an immune response in a mammal. Also featured are screening methods for identifying additional agents capable of modulating the activation of an immune cell exposed to an antigen.

公开(公告)号：US20200255837A9

公开(公告)日：2020-08-13

申请号：US16099404

申请日：2017-05-05

Applicant: Exicure, Inc.

Inventor： Bart Anderson ,  Subbarao Nallagatla ,  Richard Kang ,  Ekambar Kandimalla

IPC: C12N15/117 ,  A61K9/127 ,  C07K16/28 ,  A61K39/395

Abstract: Aspects of the invention relate to compositions of spherical nucleic acids (SNAs) composed of a liposome or lipoplex complex having an oligonucleotide shell with CpG oligonucleotides positioned on the exterior of the liposome or lipoplex. The invention also relates to methods of treating subjects and of inducing cytokine expression in a subject using the compositions described herein.

公开(公告)号：US10688177B2

公开(公告)日：2020-06-23

申请号：US15862209

申请日：2018-01-04

Applicant: LABYRINTH HOLDINGS, LLC

Inventor： Elizabeth McKenna

IPC: A61K39/39 ,  C12N15/117 ,  A61K35/74 ,  A61K45/06 ,  A61K9/00 ,  A61K39/00

Abstract: The present invention relates to combination therapies for the treatment of a variety of disorders in mammals, including hepatic disorders and cancer. The combination of agents includes naturally-occurring (versus synthetic) oligonucleotides, particularly immunostimulatory oligodeoxynucleotides such as CpG ODNs, obtained from a natural source and one or more extracts from a Gram positive bacteria, such as Lactobacillus spp.

公开(公告)号：US10683508B2

公开(公告)日：2020-06-16

申请号：US15962414

申请日：2018-04-25

Applicant: Bayer Animal Health GmbH

Inventor： Marc Munnes ,  Christian Weiss ,  Elisabeth Feldhues ,  Romina G. Schauer ,  Albert Abraham ,  Andrea Eicker ,  Hermann Wehlmann

IPC: C07H21/04 ,  A61K31/70 ,  C12N15/117 ,  A61K39/245 ,  A61K39/108 ,  A61K45/06 ,  A61K47/54 ,  A61K9/127 ,  A01K67/00 ,  A61K39/00

Abstract: The present invention relates to immunomodulator compositions and methods of use as well as methods of making. The immunomodulator compositions comprise immunostimulatory plasmids, or DNA sequence, capable of eliciting an immune response in a recipient subject. Further, the immunostimulatory plasmids, or DNA sequence, do not contain antibiotic resistance coding sequence to help reduce the potential of horizontal transfer of antibiotic resistance in a population.

公开(公告)号：US20200164066A1

公开(公告)日：2020-05-28

申请号：US16630744

申请日：2018-07-17

Applicant: University of Saskatchewan

Inventor： Susantha Gomis ,  Shelly Popowich ,  Kalhari Venukala Bandara Goonewardene ,  Suresh Tikoo ,  Marianna Foldvari

IPC: A61K39/39 ,  A23K20/153 ,  A23K50/75 ,  C12N15/117

Abstract: This application relates to compositions comprising one or more CpG oligodeoxynucleotides complexed to nanoparticles comprising a gemini surfactant and optionally a muco-adhesive polymer, which can be used for intrapulmonary delivery to induce immunity in feed animals, and the methods of making and uses thereof.