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公开(公告)号：US20160194642A1
公开(公告)日：2016-07-07
申请号：US14907455
申请日：2014-07-25
Applicant: EXICURE, INC.
Inventor： Sergei Gryaznov , Christopher C. Mader , Tiffany L. Halo , Aleksandar Filip Radovic-Moreno , Clayton Rische , Sagar Anantatmula
IPC: C12N15/117 , A61K47/48 , A61K39/39
CPC classification number: C12N15/117 , A61K39/39 , A61K47/6923 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , C12N2310/14 , C12N2310/17 , C12N2310/315 , C12N2310/351 , C12N2310/3515 , C12N2320/30
Abstract: Aspects of the invention relate to nanoscale constructs and related methods and compositions thereof. The compositions of the invention are useful for treating disorders that are sensitive to levels of immune cell activation, such as autoimmune disease or other inflammation based disease or disorder.
Abstract translation: 本发明的方面涉及纳米级构造及其相关方法及其组合物。 本发明的组合物可用于治疗对免疫细胞活化水平敏感的疾病，例如自身免疫性疾病或其它基于炎症的疾病或病症。
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2.发明申请SPHERICAL NUCLEIC ACID-BASED CONSTRUCTS AS IMMUNOSTIMULATORY AGENTS FOR PROPHYLACTIC AND THERAPEUTIC USE 审中-公开作为用于预防和治疗用途的免疫增强剂的球形核酸基结构公开(公告)号：US20160186178A1
公开(公告)日：2016-06-30
申请号：US14907430
申请日：2014-07-25
Applicant: EXICURE, INC.
Inventor： Aleksandar Filip Radovic-Moreno , Christopher C. Mader , Subbarao Nallagatla , Warefta Hasan , Aaron Love , Sergei Gryaznov
IPC: C12N15/117 , A61K39/39
CPC classification number: C12N15/117 , A61K39/39 , A61K2039/55561 , B82Y5/00 , C12N2310/17 , C12N2320/30 , C12N2320/32
Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof. The compositions of the invention are useful for activating agonists of nucleic acid interacting complexes, such as TLRs, stimulating an immune response, and treating diseases such as infectious disease, cancer, allergies, allergic diseases, and autoimmune disease
Abstract translation: 本发明的方面涉及基于球形核酸的构建体及其相关方法及其组合物。 本发明的组合物可用于激活核酸相互作用复合物（例如TLR）的激动剂，刺激免疫应答，以及治疗疾病如感染性疾病，癌症，变态反应，过敏性疾病和自身免疫性疾病
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公开(公告)号：US20210102211A1
公开(公告)日：2021-04-08
申请号：US17066134
申请日：2020-10-08
Applicant: Exicure, Inc.
Inventor： Aleksandar Filip Radovic-Moreno , Christopher C. Mader , Subbarao Nallagatla , Warefta Hasan , Aaron Love , Sergei Gryaznov
IPC: C12N15/117 , A61K39/39
Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof. The compositions of the invention are useful for activating agonists of nucleic acid interacting complexes, such as TLRs, stimulating an immune response, and treating diseases such as infectious disease, cancer, allergies, allergic diseases, and autoimmune disease
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4.发明申请公开(公告)号：US20170157048A1
公开(公告)日：2017-06-08
申请号：US15315538
申请日：2015-06-04
Applicant: Exicure, Inc.
Inventor： Aleksandar Filip Radovic-Moreno , Richard Kang , Subbarao Nallagatla , Christopher C. Mader , Sergei Gryaznov
Abstract: Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.
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Patent Agency Ranking
5.发明申请公开(公告)号：US20200069587A1
公开(公告)日：2020-03-05
申请号：US16569007
申请日：2019-09-12
Applicant: Exicure, Inc.
Inventor： Aleksandar Filip Radovic-Moreno , Richard Kang , Subbarao Nallagatla , Christopher C. Mader , Sergei Gryaznov
Abstract: Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.
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公开(公告)号：US10434064B2
公开(公告)日：2019-10-08
申请号：US15315538
申请日：2015-06-04
Applicant: Exicure, Inc.
Inventor： Aleksandar Filip Radovic-Moreno , Richard Kang , Subbarao Nallagatla , Christopher C. Mader , Sergei Gryaznov
IPC: C12N15/113 , A61K9/127 , A61K39/00 , A61K39/02 , A61K39/12 , A61K39/35 , A61K39/385 , B82Y5/00 , A61K47/69
Abstract: Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.
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公开(公告)号：US20180042848A1
公开(公告)日：2018-02-15
申请号：US15552115
申请日：2016-02-18
Applicant: Exicure, Inc.
Inventor： Sergei Gryaznov , Aleksandar Filip Radovic-Moreno , Christopher C. Mader , Tiffany L. Halo , Richard Kang , Subbarao Nallagatla , Clayton Rische , Sagar Anantatatmula
IPC: A61K9/127 , A61K47/69 , A61K31/711 , A61K31/713
CPC classification number: A61K9/1271 , A61K9/127 , A61K31/711 , A61K31/713 , A61K47/6911
Abstract: Immunoregulatory spherical nucleic acids (irSNAs) composed of a lipid containing core and an inert Nucleic non-TLR antagonistic oligonucleotide shell are provided. Acid Shell These it-SNAs are useful for modulating an immune response.
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公开(公告)号：US10894963B2
公开(公告)日：2021-01-19
申请号：US14907430
申请日：2014-07-25
Applicant: Exicure, Inc.
Inventor： Aleksandar Filip Radovic-Moreno , Christopher C. Mader , Subbarao Nallagatla , Warefta Hasan , Aaron Love , Sergei Gryaznov
IPC: C12N15/117 , A61K39/39 , B82Y5/00 , A61K39/00
Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof. The compositions of the invention are useful for activating agonists of nucleic acid interacting complexes, such as TLRs, stimulating an immune response, and treating diseases such as infectious disease, cancer, allergies, allergic diseases, and autoimmune disease
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9.发明申请公开(公告)号：US20180320184A1
公开(公告)日：2018-11-08
申请号：US15980428
申请日：2018-05-15
Applicant: Exicure, Inc.
Inventor： Aleksandar Filip Radovic-Moreno , Christopher C. Mader , Subbarao Nallagatla , Warefta Hasan , Aaron Love , Sergei Gryaznov
IPC: C12N15/117 , A61K39/39 , B82Y5/00 , A61K39/00
CPC classification number: C12N15/117 , A61K39/39 , A61K2039/55561 , B82Y5/00 , C12N2310/17 , C12N2320/30 , C12N2320/32
Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof. The compositions of the invention are useful for activating agonists of nucleic acid interacting complexes, such as TLRs, stimulating an immune response, and treating diseases such as infectious disease, cancer, allergies, allergic diseases, and autoimmune disease
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