公开(公告)号：US20030218746A1

公开(公告)日：2003-11-27

申请号：US10153128

申请日：2002-05-21

发明人： Nicholas M. Sampas

IPC分类号： G01N021/64

CPC分类号： G01N21/6452 ,  G01N21/6428

摘要： Apparatus and methods are disclosed for imaging surfaces that comprise a sample. One embodiment of the present invention is an imaging apparatus comprising a holder for a surface, a light source adapted to illuminate the surface, a diffractive element between the holder and the light source and an imaging detector adapted to receive light from the surface. In a method for imaging a surface comprising a plurality of discrete features, light is selectively diffracted on to one or more predetermined features of the surface at a predetermined point in time. This step is repeated until substantially all of the features on the surface are illuminated. Light is detected from the surface to thereby image the surface.

摘要翻译： 公开了用于对包含样品的表面进行成像的装置和方法。 本发明的一个实施例是一种成像设备，其包括用于表面的保持器，适于照亮表面的光源，保持器和光源之间的衍射元件以及适于接收来自表面的光的成像检测器。 在用于成像包括多个离散特征的表面的方法中，光在预定的时间点被选择性地衍射到表面的一个或多个预定特征。 重复该步骤直到基本上表面上的所有特征被照亮。 从表面检测光，从而对表面进行成像。

公开(公告)号：US20030198963A1

公开(公告)日：2003-10-23

申请号：US10126153

申请日：2002-04-19

发明人： Leslie Leonard ,  David King

IPC分类号： G01N021/64 ,  C12Q001/68

CPC分类号： G01N21/645 ,  G01N2021/6439 ,  G01N2021/6469 ,  G01N2021/6482

摘要： An apparatus for enhancing the collection of optical signals comprises a waveguide, which comprises a structure in a channel adapted for the flow of assay fluid. In one embodiment, fluorophore is coupled to a surface of the structure, where the fluorophore has a receptor for an analyte (ligand) in the assay fluid and the structure is adapted to transmit optical signals from the fluorophore to a detector that is adapted to detect optical signals from the fluorophore coupled to the waveguide.

摘要翻译： 用于增强光学信号收集的装置包括波导，其包括适于测定流体流动的通道中的结构。 在一个实施方案中，荧光团耦合到结构的表面，其中荧光团具有分析流体中分析物（配体）的受体，并且该结构适于将光信号从荧光团传输到适于检测的检测器 来自耦合到波导的荧光团的光信号。

公开(公告)号：US20030189178A1

公开(公告)日：2003-10-09

申请号：US10384037

申请日：2003-03-07

发明人： Daniel E. Wagoner ,  Michael L. Taylor ,  John C. Clayton ,  John D. Fitts ,  Greg L. Benfer ,  Lynn E. Johnson

IPC分类号： G01N021/64

CPC分类号： G01N21/6447 ,  B64F5/30 ,  B64F5/60 ,  G01N21/643

摘要： A method of detecting a non-fixed object in a system (12) includes applying a light emitting or generating substance to multiple objects. The objects are illuminated with an object illuminator (13). At least one of the objects (10) is determined to be a nonmember within a known pattern of objects and is identified to be a non-fixed object in response to illumination of the objects.

摘要翻译： 一种在系统（12）中检测非固定物体的方法包括将发光或产生物质施加到多个物体上。 物体用对象照明器（13）照亮。 对象（10）中的至少一个被确定为已知对象模式内的非成员，并且被响应于对象的照明被识别为非固定对象。

公开(公告)号：US20030178577A1

公开(公告)日：2003-09-25

申请号：US10338051

申请日：2003-01-08

发明人： Petri Aronkyto

IPC分类号： G01N021/64

CPC分类号： G01N21/645 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0826

摘要： An apparatus for measuring fluorescence from a sample, where an excitation system includes optical fibers or optical fiber bundles each starting from two or more lasers and mingled so as to form a single optical fiber bundle. Excitation light beams can be passed separately or simultaneously directly via this optical fiber bundle or via a common optical fiber bundle to a sample.

摘要翻译： 一种用于测量来自样品的荧光的装置，其中激发系统包括光纤或光纤束，每个光纤或光纤束从两个或更多个激光器开始并混合以形成单个光纤束。 激发光束可以通过该光纤束或通过公共光纤束分别或同时直接通过到样品。

公开(公告)号：US20030174324A1

公开(公告)日：2003-09-18

申请号：US10408870

申请日：2003-04-08

发明人： Perry Sandstrom

IPC分类号： G01N021/64

CPC分类号： G01N21/6452 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00439 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00639 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00693 ,  B01J2219/00704 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y30/00 ,  C40B60/08 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6456

摘要： The present invention relates to novel systems, devices, and methods comprising spatial light modulators for use in the reading and synthesis of microarrays. For example, the present invention provides micromirror systems for synthesizing and acquiring data from nucleic acid microarrays and systems for collecting, processing, and analyzing data obtained from a microarray.

公开(公告)号：US20030173525A1

公开(公告)日：2003-09-18

申请号：US10313892

申请日：2002-12-06

发明人： Mark Seville

IPC分类号： G01N021/64

CPC分类号： G01N21/6447 ,  G01N21/6428

摘要： Systems, devices and methods are provided for viewing a pattern of fluorophors capable of fluorescing when exposed to visible light, e.g., fluorescently stained DNA, protein or other biological material. The system includes a light source emitting light in the visible spectrum, such as a fluorescent lamp used in domestic lighting, a first optical filter capable of transmitting light from the source at wavelengths capable of exciting the fluorophors and of absorbing light of other wavelengths, and a second optical filter capable of blocking substantially all the light from the source not blocked by the first filter, so that the only light reaching the viewer is light produced by fluorescence of the fluorophors.

公开(公告)号：US20030164457A1

公开(公告)日：2003-09-04

申请号：US10340781

申请日：2003-01-13

申请人： SONY CHEMICALS CORP.

发明人： Hiroyuki Kumakura

IPC分类号： G01N021/64

CPC分类号： G01N21/6458 ,  G01N21/6428 ,  H05K1/0269 ,  H05K3/305 ,  H05K3/323

摘要： In a method for non-destructively testing the curing level of the cured product of a curable adhesive composition, a fluorescent component that emits fluorescent light upon irradiation with excitation light is added to the curable adhesive composition, the curable adhesive composition containing this fluorescent component is cured, the cured product thus obtained is irradiated with excitation light, and the fluorescent light thus produced is observed to test the curing level of the cured product.

摘要翻译： 在对可固化粘合剂组合物的固化产物的固化水平进行非破坏性测试的方法中，将含有该荧光成分的可固化粘合剂组合物添加到可固化粘合剂组合物中，在用激发光照射时发射荧光的荧光成分是 固化，用激发光照射由此获得的固化产物，观察所产生的荧光，以测试固化产物的固化水平。

公开(公告)号：US20030160181A1

公开(公告)日：2003-08-28

申请号：US10086743

申请日：2002-02-28

发明人： John F. Corson ,  Stanley P. Woods ,  Russell A. Parker ,  Xiangyang Zhou ,  Bo U. Curry

IPC分类号： G01N021/64

CPC分类号： G01N21/6452 ,  G01N21/6458 ,  G01N2021/6463

摘要： An automated method and system for determining an optimal focus distance for scanning a molecular array scanner. Blocks of rows of a reference array are automatically scanned at successively greater distances of the stage from a light gathering medium, such as an optical fiber, or z-positions, to produce data providing a functional relationship between z-position and measured signal intensities. The data is then processed by a peak-height-based, or window-based, focus-finding routine that selects an optimal focus-distance for data scans.

摘要翻译： 一种用于确定用于扫描分子阵列扫描仪的最佳聚焦距离的自动化方法和系统。 参考阵列的行的块自动地从阶段相对较远的距离光收集介质（诸如光纤或z位置）扫描，以产生提供z位置和测量的信号强度之间的功能关系的数据。 然后通过基于峰值高度或基于窗口的聚焦寻找程序处理数据，该程序为数据扫描选择最佳聚焦距离。

公开(公告)号：US20030157727A1

公开(公告)日：2003-08-21

申请号：US10204418

申请日：2003-02-04

发明人： Tetsuo Nagano ,  Kazuya Kikuchi ,  Mitsunori Koresawa ,  Hirotatsu Kojima

IPC分类号： G01N021/64

CPC分类号： G01N33/542 ,  G01N21/6428 ,  G01N2021/6441

摘要： A method for measurement of a target substance in a sample by means of fluorescence, which comprises the step of carrying out the measurement in the presence of (1) a specific fluorescent probe which specifically reacts with the target substance to generate fluorescence, and (2) a donor which, per se, has long-lived fluorescence and is capable of inducing fluorescence resonance energy transfer to the specific fluorescent probe that acts as an acceptor, provided that the donor forms no binding to the specific fluorescent probe by means of a chemical bond; and the step of converting fluorescence, wherein said fluorescence is resulted from a reaction between the acceptor and the target substance, into long-lived excitation fluorescence by the fluorescence resonance energy transfer which is induced on the acceptor.

摘要翻译： 一种通过荧光测定样品中的目标物质的方法，包括在（1）特异性荧光探针存在下进行测定的步骤的步骤，所述荧光探针与目标物质特异性反应以产生荧光，和（2 ）供体本身具有长寿命的荧光，并且能够诱导荧光共振能量转移到用作受体的特定荧光探针，条件是供体通过化学物质不与特定荧光探针结合 键; 以及通过在受体上诱导的荧光共振能量转移，将受体和目标物质之间的反应产生的荧光转化为长寿命激发荧光的步骤。

公开(公告)号：US20030155527A1

公开(公告)日：2003-08-21

申请号：US10335236

申请日：2002-12-30

申请人： Olympus Optical Co., Ltd.

发明人： Yasuaki Natori

IPC分类号： G01N021/64

CPC分类号： G01N21/6458 ,  G02B21/16

摘要： According to the present invention, there is disclosed a microscope system comprising a single microscope comprising a laser source, a light path splitting unit which splits a light path of a laser beam from the laser source into at least two, a plurality of optical fibers upon which laser beams on the light paths split by the light path splitting unit are incident, and a plurality of different microscope optical systems which use the respective laser beams passed through the plurality of optical fibers.

摘要翻译： 根据本发明，公开了一种显微镜系统，其包括单个显微镜，其包括激光源，光路分离单元，其将来自激光源的激光束的光路分成至少两个，多个光纤， 通过光路分离单元分裂的光路上的激光束入射，并且使用各激光束的多个不同的显微镜光学系统通过多根光纤。