公开(公告)号：US10406243B2

公开(公告)日：2019-09-10

申请号：US14913978

申请日：2014-08-18

Applicant: National University Corporation Tokyo Medical and Dental University

Inventor： Atsushi Tamura ,  Nobuhiko Yui

IPC: A61K9/00 ,  A61K47/69

Abstract: A medicinal composition for diseases caused by dyslipidemia and/or autophagy dysfunction, etc., said medicinal composition comprising polyrotaxane that carries bulky substituents introduced, via intracellularly degradable bonds, into both ends of a linear molecule penetrating through plural cyclic molecules.

公开(公告)号：US20190247414A1

公开(公告)日：2019-08-15

申请号：US16335017

申请日：2017-09-25

Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

Inventor： Takanori Yokota ,  Tetsuya Nagata

IPC: A61K31/711 ,  A61K47/22 ,  A61K47/28 ,  C12N15/113 ,  A61K47/54 ,  A61P27/02 ,  A61P25/00 ,  A61K31/7125 ,  A61K9/00

CPC classification number: A61K31/711 ,  A61K9/0019 ,  A61K31/7088 ,  A61K31/7125 ,  A61K47/22 ,  A61K47/28 ,  A61K47/542 ,  A61K47/554 ,  A61K48/00 ,  A61P25/00 ,  A61P27/02 ,  C12N15/09 ,  C12N15/113

Abstract: The present invention provides a composition and a method for efficiently delivering a nucleic acid agent to the central nervous system and/or the retina and bringing about antisense effects. Provided is a composition for reducing the expression level of a target transcription product in the central nervous system and/or retina of a subject, the composition including a nucleic acid complex that includes a first nucleic acid strand and a second nucleic acid strand, wherein: the first nucleic acid strand comprises a base sequence capable of hybridizing with at least part of the target transcription product and has an antisense effect on the target transcription product; the second nucleic acid strand comprises a base sequence complementary to the first nucleic acid strand and is conjugated to tocopherol, cholesterol, or an analog thereof; and the first nucleic acid strand is annealed to the second nucleic acid strand.

公开(公告)号：US20190240352A1

公开(公告)日：2019-08-08

申请号：US16337808

申请日：2017-09-29

Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

Inventor： Takanori Yokota ,  Kotaro Yoshioka

IPC: A61K48/00 ,  A61K9/00 ,  A61K9/70 ,  A61K31/7125 ,  A61P35/00 ,  A61P25/28

CPC classification number: A61K48/0066 ,  A61K9/0019 ,  A61K9/7023 ,  A61K31/7088 ,  A61K31/7125 ,  A61K48/00 ,  A61P25/28 ,  A61P35/00 ,  C12N15/09 ,  C12N15/113

Abstract: Provided is a nucleic acid strand that can efficiently deliver an antisense oligonucleotide into the body, particularly a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein the first nucleic acid strand includes a base sequence that is capable of hybridizing with at least a portion of a target transcription product, and exerts an antisense effect on the target transcription product; the second nucleic acid strand includes a complementary region having a base sequence complementary to the first nucleic acid strand and at least one overhang region located on the 5′ and/or 3′ side of the complementary region; and the first nucleic acid strand is annealed to the complementary region in the second nucleic acid strand.

公开(公告)号：US20190167135A1

公开(公告)日：2019-06-06

申请号：US16198962

申请日：2018-11-23

Applicant: Yoshinori Okada ,  Yoshihisa Naijo ,  Hiroshi Deguchi ,  Taishi Watanabe ,  Yuki Miyano ,  Shigenori Kawabata

Inventor： Yoshinori Okada ,  Yoshihisa Naijo ,  Hiroshi Deguchi ,  Taishi Watanabe ,  Yuki Miyano ,  Shigenori Kawabata

IPC: A61B5/04 ,  A61B5/00

Abstract: A biomagnetic measurement apparatus includes a table on which a subject is placed; a biomagnetic detector configured to detect a biomagnetic field of the subject; a supporter configured to support a detection target region from which the biomagnetic field of the subject is detected; a radiation detector provided below the supporter; and a position changer configured to change relative positions of the biomagnetic detector and the detection target region. The supporter has a surface shape that corresponds to a surface of the biomagnetic detector.

公开(公告)号：US20190125205A1

公开(公告)日：2019-05-02

申请号：US16307192

申请日：2017-06-06

Applicant: National University Corporation Tokyo Medical and Dental University ,  TDK CORPORATION

Inventor： Shigenori Kawabata ,  Shuichi Okawa ,  Shuta Ushio

IPC: A61B5/05 ,  A61B5/024

Abstract: The present invention addresses the problem of providing a muscle activity measurement device and a muscle activity measurement method which make it possible to measure the muscle activity of an object to be sensed with increased accuracy. The muscle activity measurement device 1 according to the present invention is provided with a magnetic sensor unit 11 which senses a magnetic field generated from a living body, and an identification means which identifies an installed direction of the muscle activity measurement device 1. The identification means includes an indication 24, on a surface of a container 20, which comprises identification information for installing the muscle activity measurement device 1 in such a way that a magnetism sensing direction X of the magnetic sensor unit 11 and the direction in which the muscle fibers of the living body as the object to be sensed extend are substantially orthogonal to each other.

公开(公告)号：US10219888B2

公开(公告)日：2019-03-05

申请号：US11455112

申请日：2006-06-19

Applicant: Ikuo Morita ,  Akiko Kobayashi ,  Hideshi Hattori ,  Masatoshi Kuroda

Inventor： Ikuo Morita ,  Akiko Kobayashi ,  Hideshi Hattori ,  Masatoshi Kuroda

IPC: A61F2/02 ,  A61L27/38 ,  A61L27/58 ,  C12N5/071 ,  A61L27/36 ,  B82Y30/00 ,  C12N5/00 ,  A61K35/12

Abstract: In accordance with the present invention, an implant in which cells are arranged in a fine pattern that is available for immediate implantation and that does not need to be removed after implantation is provided. The present invention relates to a cell-containing sheet, which comprises cells and a support comprising a bioabsorbable material, in which the support has a cell adhesion protein-containing layer on the surface thereof and the cells form a pattern on the support.

公开(公告)号：US20180333495A1

公开(公告)日：2018-11-22

申请号：US15770125

申请日：2016-10-24

Applicant: National University Corporation Tokyo Medical and Dental University

Inventor： Akira MATSUMOTO ,  Hiroko MATSUMOTO ,  Takayoshi SUGANAMI ,  Miyako TANAKA ,  Yuji MIYAHARA

IPC: A61K47/32 ,  A61K38/28 ,  A61K9/70 ,  C08F220/56

CPC classification number: A61K47/32 ,  A61K9/00 ,  A61K9/70 ,  A61K38/28 ,  A61K47/16 ,  A61M5/24 ,  A61M5/3291 ,  A61M25/0043 ,  A61M37/0015 ,  C08F220/56 ,  C08F2800/10

Abstract: An improved device capable of releasing a drug in response to stimuli such as a glucose concentration is provided. Provided is a drug delivery device, including a porous body such as a hollow fiber having biocompatibility and drug permeability, a stimuli-responsive gel composition filling inside of the porous body, and a drug surrounded by the gel composition inside of the porous body.

公开(公告)号：US20180320181A1

公开(公告)日：2018-11-08

申请号：US16021165

申请日：2018-06-28

Applicant: National University Corporation Tokyo Medical and Dental University ,  Osaka University

Inventor： Takanori Yokota ,  Kazutaka Nishina ,  Satoshi Obika ,  Hidehiro Mizusawa

IPC: C12N15/113 ,  C12N15/11

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/15 ,  C12N2310/3181 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/3513 ,  C12N2310/3515 ,  C12N2310/53 ,  C12N2320/52

Abstract: A method of reducing the level of a transcription product in a cell comprising contacting with the cell a composition comprising a double-stranded nucleic acid complex comprising a first nucleic acid strand annealed to a second nucleic acid strand, wherein: (i) the first nucleic acid strand hybridizes to the transcription product and comprises (a) a region consisting of at least 4 consecutive nucleotides that are recognized by RNase H when the strand is hybridized to the transcription product, (b) one or more nucleotide analogs located on 5′ terminal side of the region, (c) one or more nucleotide analogs located on 3′ terminal side of the region and (d) a total number of nucleotides and nucleotide analogs ranging from 8 to 35 nucleotides and (ii) the second nucleic acid strand comprises (a) nucleotides and optionally nucleotide analogs and (b) at least 4 consecutive RNA nucleotides.

公开(公告)号：US20180242861A1

公开(公告)日：2018-08-30

申请号：US15756298

申请日：2016-08-27

Applicant: COSMOTEC CO.,LTD. ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

Inventor： Yoshinori INOUE ,  Sotaro KATSUI ,  Takashi OZAKI ,  Koji YONEMARU

IPC: A61B5/026 ,  A61B5/00 ,  A61F7/08

Abstract: In order to obtain a new index value clearly indicating a state of blood circulation, the present invention is characterized by comprising: performing multiple measurements of the blood flow rate in a biological tissue over time; calculating the slope of change over time in the measured blood flow rate; and displaying the value of the calculated slope.

公开(公告)号：US20180199953A1

公开(公告)日：2018-07-19

申请号：US15743329

申请日：2016-07-12

Applicant: National University Corporation Tokyo Medical and Dental University ,  TORAY ENGINEERING CO., LTD.

Inventor： Kenji Kawashima ,  Takahiro Kanno ,  Ryoken Miyazaki ,  Keiichi Akahoshi ,  Daisuke Ban ,  Minoru Tanabe

IPC: A61B17/29

Abstract: A forceps system includes a forceps manipulator and a control unit. The forceps manipulator includes a forceps tip unit capable of bending with two degrees of freedom including a bending direction and a bending angle, a drive unit that generates a driving force for the forceps tip unit, an operation unit for instructing the bending direction and the bending angle, and a first detection unit that detects an angle in a rotation direction with respect to an axis of the drive transmitting unit. The control unit that controls the drive unit such that the forceps tip unit bends depending on a predetermined target bending direction and a predetermined target bending angle. The control unit sets a target bending direction on the basis of the bending direction instructed from the operation unit and the angle detected by the first detection unit.