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123 条记录 (耗时 0.04 秒)

    PKC Delta Inhibitors for use as Therapeutics
    91.
    发明申请
    PKC Delta Inhibitors for use as Therapeutics 有权
    PKC Delta抑制剂用作治疗剂

    公开(公告)号：US20160250183A1

    公开(公告)日：2016-09-01

    申请号：US15148420

    申请日：2016-05-06

    申请人： Douglas V. Faller ,  Robert M. Williams

    发明人： Douglas V. Faller ,  Robert M. Williams

    IPC分类号： A61K31/403 ,  G01N33/50 ,  A61K9/00

    CPC分类号： A61K31/403 ,  A61K9/0019 ,  A61K31/404 ,  A61K45/06 ,  A61P35/00 ,  C07D209/86 ,  C07D405/06 ,  C07D487/14 ,  C12Y207/10002 ,  G01N33/5011 ,  G01N2333/91205

    摘要： The invention is directed to compounds that are specific inhibitors of PKC delta, and methods and compositions for the treatment and prevention of cancers and other disorders. Compositions comprising compounds of the invention are used to treat cancers such as, for example, carcinoid and neuroendocrine tumors, malignant melanomas, pancreatic, gastrointestinal and lung cancers. Neuroendocrine tumor cell lines of pulmonary and gastrointestinal origin are surprisingly sensitive to PKC delta inhibition by the compounds of the invention. The invention is further directed to methods, compositions and kits containing compounds of the formulas (Ia), (IIa), (IIIa), (IVa), and (V) as disclosed and described in FIGS. 11 and 12.

    摘要翻译： 本发明涉及作为PKCδ特异性抑制剂的化合物，以及用于治疗和预防癌症和其它病症的方法和组合物。 包含本发明化合物的组合物用于治疗癌症例如类癌和神经内分泌肿瘤，恶性黑素瘤，胰腺癌，胃肠癌和肺癌。 肺和胃肠道起源的神经内分泌肿瘤细胞系对本发明化合物对PKCδ抑制的惊人的敏感性。 本发明进一步涉及包含如图1和2中公开和描述的式（Ia），（IIa），（IIIa），（IVa）和（V）化合物的方法，组合物和试剂盒。 11和12。

    TOOTHED GRIPPER MEMBERS, PLUMBING CONNECTION ASSEMBLIES AND METHODS FOR FORMING THE SAME
    96.
    发明申请
    TOOTHED GRIPPER MEMBERS, PLUMBING CONNECTION ASSEMBLIES AND METHODS FOR FORMING THE SAME 审中-公开
    带齿的抓斗构件，连接连接组件及其形成方法

    公开(公告)号：US20090194990A1

    公开(公告)日：2009-08-06

    申请号：US12026015

    申请日：2008-02-05

    申请人： Robert M. Williams

    发明人： Robert M. Williams

    IPC分类号： F16L55/00

    CPC分类号： F16L19/08 ,  F16L21/08 ,  F16L37/091

    摘要： A gripper member for forming a mechanical connection with tubing includes an annular ring body and a plurality of teeth extending from the ring body. Each tooth has a tooth length and a fixed end and an opposed free end spaced apart along the tooth length, wherein the fixed end adjoins the ring body. The teeth are angled radially inwardly from the ring body such that the free ends define an inner engagement circumference to receive the tubing. Each tooth has a substantially creased lengthwise bend therein extending to the free end thereof.

    摘要翻译： 用于形成与管道的机械连接的夹持器构件包括环形环体和从环形体延伸的多个齿。 每个齿具有齿长和固定端以及沿齿长间隔开的相对自由端，其中固定端邻接环体。 齿从环形体径向向内成角度，使得自由端限定内部接合圆周以接收管道。 每个牙齿具有延伸到其自由端的基本上增加的纵向弯曲。

    Apparatus and method for supporting pallet extending from patient table
    98.
    发明授权
    Apparatus and method for supporting pallet extending from patient table 失效
    用于支撑从患者台延伸的托盘的装置和方法

    公开(公告)号：US07077569B1

    公开(公告)日：2006-07-18

    申请号：US10732089

    申请日：2003-12-10

    申请人： Andrew P. Tybinkowski ,  Robert F. Riemer ,  Robert M. Williams

    发明人： Andrew P. Tybinkowski ,  Robert F. Riemer ,  Robert M. Williams

    IPC分类号： A61B6/04

    CPC分类号： A61B6/04

    摘要： An apparatus for supporting a pallet extending horizontally from a patient table, including a horizontally extended pallet support for supporting a horizontally extendable pallet of a patient table, and a lifting assembly for vertically supporting the pallet support. The lifting assembly includes a lower base and at least one pair of non-intersecting front and rear lift arms holding the pallet support vertically above the lower base. Each lift arm includes a lower end pivotally connected to the lower base, an upper end pivotally connected to the pallet support, an elbow located between the lower end and the upper end, an elongated lower portion extending between the lower end and the elbow, and an elongated upper portion extending between the elbow to the upper end, with the lower portion and the upper portion connecting at an angle at the elbow.

    摘要翻译： 一种用于支撑从患者桌面水平延伸的托盘的装置，包括用于支撑患者台的水平延伸的托盘的水平延伸的托板支撑件和用于垂直支撑托盘支撑件的提升组件。 提升组件包括下基座和至少一对不相交的前和后提升臂，其将托盘支撑件垂直地保持在下底座上方。 每个提升臂包括可枢转地连接到下基部的下端，可枢转地连接到托盘支撑件的上端，位于下端和上端之间的弯头，在下端和肘部之间延伸的细长下部，以及 在肘部与上端之间延伸的细长的上部，下部和上部以肘部成一定角度连接。

    Combined tomography scanners
    99.
    发明授权
    Combined tomography scanners 失效
    组合式断层扫描仪

    公开(公告)号：US06831961B1

    公开(公告)日：2004-12-14

    申请号：US10161434

    申请日：2002-06-03

    申请人： Andrew P. Tybinkowski ,  Robert F. Riemer ,  Robert M. Williams

    发明人： Andrew P. Tybinkowski ,  Robert F. Riemer ,  Robert M. Williams

    IPC分类号： A61B600

    CPC分类号： G01T1/2985 ,  A61B6/032 ,  A61B6/5235

    摘要： A multi-scanner frame in accordance with the principles of the present invention includes a base and a plurality of stands. Each stand supports a tomography gantry. The plurality of scanners supported by the gantries may represent a plurality of tomography modalities. A linear guide allows for the ready movement of at least one of the gantries relative to one or more remaining gantries.

    摘要翻译： 根据本发明的原理的多扫描仪框架包括基座和多个支架。 每个支架支持断层扫描架。 由台架支撑的多个扫描仪可以表示多个断层摄影模式。 线性引导件允许框架中的至少一个相对于一个或多个剩余的门架准备移动。

    High voltage electrical connection for a display screen
    100.
    发明授权
    High voltage electrical connection for a display screen 失效
    显示屏高压电气连接

    公开(公告)号：US06488517B1

    公开(公告)日：2002-12-03

    申请号：US09146869

    申请日：1998-09-03

    申请人： Robert M. Williams ,  Richard H. Plourde, Jr.

    发明人： Robert M. Williams ,  Richard H. Plourde, Jr.

    IPC分类号： H01R300

    CPC分类号： G06F1/1637 ,  G06F1/1616 ,  G06F1/1683 ,  G06F1/266 ,  H01R13/53 ,  H01R35/02 ,  H01R2201/06

    摘要： A high voltage electrical connection between a base unit and a panel display in a portable computer wherein the base unit and the panel display are pivotably secured to each other about a hinge axis, includes a flexible high voltage electrical conductor extending from the base unit to the panel display. A portion of the electrical conductor extends along the hinge axis such that pivoting of the panel display relative to the base unit causes said portion of the flexible conductor to twist about the hinge axis rather than actively bend.

    摘要翻译： 便携式计算机中的基座单元和面板显示器之间的高压电连接，其中基座单元和面板显示器围绕铰链轴线可枢转地彼此固定，包括柔性高压电导体，其从基座单元延伸到 面板显示。 电导体的一部分沿着铰链轴线延伸，使得面板显示器相对于基座单元的枢转​​导致柔性导体的所述部分围绕铰链轴线扭转而不是主动弯曲。