公开(公告)号：US20110224959A1

公开(公告)日：2011-09-15

申请号：US13081007

申请日：2011-04-06

申请人： Xiao-Yi Zhang ,  Anton Nemet

发明人： Xiao-Yi Zhang ,  Anton Nemet

IPC分类号： G06F17/10 ,  G06G7/64

CPC分类号： G05B17/02

摘要： Numerical gas turbine models permit transient modeling with high precision and at the same time numerically efficient processes for modeling a gas turbine. A gas turbine model includes a plurality of sub models. These sub models are either purely dynamic or static, which allows significant simplifications in the numerical solution of the overall model. System parts, which simulate the effects of volumes, metal masses, of actuators, and of measuring systems are regarded as dynamic. The remaining system parts are regarded as static over a time characteristic.

摘要翻译： 数值燃气轮机模型允许高精度的瞬态建模，同时对燃气轮机进行建模的数值有效的过程。 燃气轮机模型包括多个子模型。 这些子模型是纯动态的或静态的，这允许在整个模型的数值解中显着简化。 模拟体积，金属质量，执行器和测量系统的影响的系统部件被认为是动态的。 剩余的系统部件在时间特性上被视为静态的。

公开(公告)号：US20110210479A1

公开(公告)日：2011-09-01

申请号：US13037077

申请日：2011-02-28

申请人： Yingling Yang ,  Gary J. Cheng ,  Ji Li ,  Yi Zhang

发明人： Yingling Yang ,  Gary J. Cheng ,  Ji Li ,  Yi Zhang

IPC分类号： B29C35/08

CPC分类号： B23K26/063 ,  B23K26/0622 ,  B23K26/0661 ,  B23K26/0853 ,  B23K26/32 ,  B23K26/324 ,  B23K26/34 ,  B23K26/36 ,  B23K2103/50

摘要： A confined pulsed laser deposition method and apparatus that includes an ablative coating between a transparent confinement layer and a backing plane, and a laser beam directed through the confinement layer to ablate the coating at generally ambient temperature and pressure, and using laser induced pressure to synthesize metaphase from the ablative coating. For example, diamond phase carbon can be synthesized from a graphite coating. The laser beam can be directed through a focus lens to control the final spot size, or through a beam diffuser to make the intensity more uniform. An XYZ-stage can position a desired target area of the ablative coating to be irradiated by the laser beam. The laser beam can have an intensity of less than about 6 GW/cm2, or less than about 4 GW/cm2. The laser beam can have an excitation wavelength of about 568 nm.

摘要翻译： 一种限制脉冲激光沉积方法和装置，其包括透明约束层和背衬平面之间的烧蚀涂层，以及引导通过约束层的激光束，以在一般环境温度和压力下烧蚀涂层，并且使用激光诱导压力合成 烧蚀涂层的中期。 例如，可以由石墨涂层合成金相碳。 激光束可以被引导通过聚焦透镜来控制最终光斑尺寸，或者通过光束漫射器使得强度更均匀。 XYZ平台可以定位由激光束照射的烧蚀涂层的期望目标区域。 激光束可以具有小于约6GW / cm 2或小于约4GW / cm 2的强度。 激光束可以具有约568nm的激发波长。

公开(公告)号：US08005540B2

公开(公告)日：2011-08-23

申请号：US12836441

申请日：2010-07-14

申请人： Yi Zhang ,  John D. Hatlestad ,  Gerrard M. Carlson ,  Yousufali Dalal ,  Marina V. Brockway ,  Kent Lee ,  Richard O. Kuenzler ,  Carlos Haro ,  Krzysztof Z. Siejko ,  Abhilash Patangay

发明人： Yi Zhang ,  John D. Hatlestad ,  Gerrard M. Carlson ,  Yousufali Dalal ,  Marina V. Brockway ,  Kent Lee ,  Richard O. Kuenzler ,  Carlos Haro ,  Krzysztof Z. Siejko ,  Abhilash Patangay

IPC分类号： A61N1/02

CPC分类号： A61M5/1723 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/7275 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/3621 ,  A61N1/365 ,  A61N1/36585 ,  G06F19/00

摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

摘要翻译： 使用至少一个可植入装置自动评估或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

公开(公告)号：US07977050B2

公开(公告)日：2011-07-12

申请号：US11218838

申请日：2005-09-02

申请人： Michael Seul ,  Nataliya Korzheva ,  Jiacheng Yang ,  Yi Zhang

发明人： Michael Seul ,  Nataliya Korzheva ,  Jiacheng Yang ,  Yi Zhang

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6865 ,  C12Q2563/149 ,  C12Q2563/107 ,  C12Q2537/143

摘要： A method mediated with in-vitro transcription (“IVT”) which permits miniaturization of multiplexed DNA and RNA analysis, and in which elongation-mediated multiplexed analysis of polymorphisms (eMAP®) is used as the analysis step, is described. Also described is a method mediated with IVT is for selecting a designated strand from T7-tagged double stranded DNA: wherein, the selected strand forms the template for RNA synthesis. In one embodiment, double stranded DNA incorporating the T7 (or other) promoter sequence at the 3′ end or the 5′ end is produced, for example, by amplification of genomic DNA using the Polymerase Chain Reaction (PCR). Also disclosed are nested PCR designs permitting allele analysis in combination with strand selection by IVT. Further, in one embodiment of a homogeneous format for transcription-mediated amplification and multiplexed detection (which may be particularly suited for viral or pathogen detection), encoded microparticles display “looped” capture probe configurations permitting the generation of a signal upon capture of RNA product and real-time assay monitoring.

摘要翻译： 描述了使用允许多重DNA和RNA分析的小型化的体外转录（“IVT”）介导的方法，并且其中使用延长介导的多态性复合分析（eMAP）作为分析步骤。 还描述了用IVT介导的用于从T7标记的双链DNA中选择指定链的方法：其中所选择的链形成用于RNA合成的模板。 在一个实施方案中，例如通过使用聚合酶链式反应（PCR）扩增基因组DNA来产生在3'末端或5'端掺入T7（或其它）启动子序列的双链DNA。 还公开了允许等位基因分析与IVT的链选择组合的巢式PCR设计。 此外，在用于转录介导的扩增和多重检测（其可能特别适用于病毒或病原体检测）的均匀形式的一个实施方案中，编码的微粒显示允许在捕获RNA产物时产生信号的“环状”捕获探针构型 和实时检测监测。

公开(公告)号：US20110165565A1

公开(公告)日：2011-07-07

申请号：US12811581

申请日：2009-01-05

申请人： Tza-Huei Wang ,  Stephen Baylin ,  James Gordon Herman ,  Vasudev Bailey ,  Hariharan Easwaran ,  Hetty Carraway ,  Yi Zhang ,  Brian P. Keeley

发明人： Tza-Huei Wang ,  Stephen Baylin ,  James Gordon Herman ,  Vasudev Bailey ,  Hariharan Easwaran ,  Hetty Carraway ,  Yi Zhang ,  Brian P. Keeley

IPC分类号： C12Q1/68 ,  C07H1/06

CPC分类号： C12Q1/6818 ,  C12Q1/6827 ,  C12Q1/6834 ,  C12Q1/6858 ,  C12Q2565/101 ,  C12Q2535/125 ,  C12Q2563/155 ,  C12Q2523/125 ,  C12Q2563/131

摘要： The present invention features methods and compositions for methylation detection, as well as a novel method for polynucleotide extraction and sodium bisulfite treatment.

摘要翻译： 本发明的特征在于用于甲基化检测的方法和组合物，以及用于多核苷酸提取和亚硫酸氢钠处理的新方法。

公开(公告)号：US20110141683A1

公开(公告)日：2011-06-16

申请号：US12756200

申请日：2010-04-08

申请人： GUANG-YI ZHANG ,  XIAO-ZHENG LI

发明人： GUANG-YI ZHANG ,  XIAO-ZHENG LI

IPC分类号： G06F1/16 ,  H05K5/02

CPC分类号： G11B33/124 ,  G06F1/187 ,  H05K5/0221

摘要： A mounting mechanism for attaching a data storage device to a chassis includes a housing, first and second driving members, a latching member, first, second, and third elastic members. The housing defines first, second and third sliding paths therein. The first and third sliding paths extend along a first direction of the housing for receiving the first driving member and the latching member. The second sliding path extends along a second direction of the housing substantially perpendicular to the first direction for receiving the second driving member. The first driving member forms an inclined guiding surface at an end thereof outside the housing. When the guiding surface is pressed down, the driving member moves inward, driving the second driving to move and disengage from the latching member, and the latching member moves along the first direction by an elastic force of the third elastic member.

摘要翻译： 用于将数据存储装置附接到底盘的安装机构包括壳体，第一和第二驱动构件，闩锁构件，第一，第二和第三弹性构件。 壳体在其中限定第一，第二和第三滑动路径。 第一和第三滑动路径沿着壳体的第一方向延伸，用于接收第一驱动构件和闩锁构件。 第二滑动路径沿壳体的第二方向延伸，基本上垂直于第一方向，用于接收第二驱动构件。 第一驱动构件在其外部的端部处形成倾斜的引导表面。 当导向面被压下时，驱动构件向内移动，驱动第二驱动以与闩锁构件移动和脱离，并且闩锁构件通过第三弹性构件的弹力沿第一方向移动。

公开(公告)号：US20110139128A1

公开(公告)日：2011-06-16

申请号：US12816151

申请日：2010-06-15

申请人： Yi Zhang ,  Dat Le ,  Steven Antone Thiel ,  Brent Darrell Brawn

发明人： Yi Zhang ,  Dat Le ,  Steven Antone Thiel ,  Brent Darrell Brawn

IPC分类号： F02M37/04

CPC分类号： F02M37/103 ,  F02M37/106

摘要： Systems and methods are provided for a structurally supportive fuel delivery module coupled to an upper and lower wall of a fuel tank.

摘要翻译： 提供了用于结构上支持的燃料输送模块的系统和方法，其耦合到燃料箱的上壁和下壁。

公开(公告)号：US20110138488A1

公开(公告)日：2011-06-09

申请号：US12999059

申请日：2009-06-23

申请人： Yi Zhang ,  Yuki Okada ,  Keisuke Tatelshi

发明人： Yi Zhang ,  Yuki Okada ,  Keisuke Tatelshi

IPC分类号： G01N33/00 ,  A01K67/00 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/68

CPC分类号： G01N33/6893 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0362 ,  C12N9/0071 ,  C12N15/8509 ,  C12N2800/30 ,  G01N33/5008 ,  G01N33/5044 ,  G01N33/5061 ,  G01N33/5067 ,  G01N33/566 ,  G01N2500/00 ,  G01N2800/02

摘要： The present invention relates to animal models of metabolic disorders such as obesity, diabetes, metabolic syndrome, insulin resistance, hyperinsulinemia, glucose intolerance, hyperlipidemia, and the like. In particular, the invention relates to transgenic non-human animals having a reduction in functional Jhdm2a gene expression and use of such animals and cells having reduced Jhdm2a expression in drug discovery. The invention further relates to the identification of subjects having or at increased risk for developing a metabolic disorder based on a genetic marker in the Jhdm2a gene.

摘要翻译： 本发明涉及代谢性疾病如肥胖，糖尿病，代谢综合征，胰岛素抵抗，高胰岛素血症，葡萄糖不耐受，高脂血症等的动物模型。 特别地，本发明涉及具有功能性Jhdm2a基因表达降低的转基因非人动物以及在药物发现中具有降低的Jhdm2a表达的这种动物和细胞的使用。 本发明还涉及基于Jhdm2a基因中的遗传标记鉴定具有或具有增加的代谢障碍风险的受试者。

公开(公告)号：US20110137192A1

公开(公告)日：2011-06-09

申请号：US13027608

申请日：2011-02-15

申请人： Yi Zhang ,  Carlos Alberto Ricci ,  Jeffrey E. Stahmann ,  Aaron R. McCabe ,  Scott A. Meyer ,  Yinghong Yu

发明人： Yi Zhang ,  Carlos Alberto Ricci ,  Jeffrey E. Stahmann ,  Aaron R. McCabe ,  Scott A. Meyer ,  Yinghong Yu

IPC分类号： A61B5/0402

CPC分类号： A61B5/04011 ,  A61B5/7203

摘要： Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments of the present invention relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments of the invention are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.

摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断，除颤和起搏治疗，或这些功能的组合，包括结合或与神经刺激装置，药物泵或其他疗法组合的心脏系统。 本发明的实施方案一般涉及使用自动心脏激活序列监测和/或跟踪用于心律失常鉴别的可植入医疗装置。 本发明的实施例涉及使用多个可植入电极感测多个复合心脏信号的装置和方法。 使用感测的多个复合心脏信号进行源分离，并且分离产生与指示缺血的一个或多个心脏激活序列相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号矢量检测一个或多个心脏信号矢量的改变。 使用一个或多个心脏信号载体来区分心律失常。

公开(公告)号：US20110136759A1

公开(公告)日：2011-06-09

申请号：US12681052

申请日：2008-10-03

申请人： Daniel Kahne ,  Suzanne Kahne Walker ,  Masaatsu Adachi ,  Emma Doud ,  Shinichiro Fuse ,  Xiaonan Lin ,  Yi Zhang ,  Hirokazu Tsukamoto ,  Bohdan Ostash

发明人： Daniel Kahne ,  Suzanne Kahne Walker ,  Masaatsu Adachi ,  Emma Doud ,  Shinichiro Fuse ,  Xiaonan Lin ,  Yi Zhang ,  Hirokazu Tsukamoto ,  Bohdan Ostash

IPC分类号： A61K31/7024 ,  C07H13/00 ,  C12P19/26 ,  A61P31/04

CPC分类号： C07H15/10 ,  C07H11/04

摘要： The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.

摘要翻译： 本发明通过向有需要的受试者施用本发明化合物来提供新颖的新霉素类似物及其药物组合物，合成方法和用于治疗感染的方法。 门霉素类似物可以合成，生物合成或半合成制备。 类似物在治疗或预防革兰氏阳性生物引起的感染中特别有用。 某些本发明化合物可具有更广泛的覆盖范围，其包括革兰氏阴性生物体。