-
公开(公告)号：US11919889B2
公开(公告)日：2024-03-05
申请号：US17698592
申请日：2022-03-18
IPC分类号： C07D413/12 , C07D265/30 , C07D413/14
CPC分类号： C07D413/12 , C07D265/30 , C07D413/14
摘要： A compound of Formula I includes a stereoisomer thereof and/or a salt thereof; wherein R1 is a substituted alkane group, a heterocylic group, or a pyridine group; X is hydrogen, a halogen, an amino acid residue, a substituted amino acid residue, an alkyl group, or an ester. Such compounds may be used in pharmaceutical compositions and for the treatment of central nervous system (CNS) disorders:
-
公开(公告)号：US11896599B2
公开(公告)日：2024-02-13
申请号：US16252106
申请日：2019-01-18
发明人： Padmanabh P. Bhatt , Argaw Kidane , Kevin Edwards
CPC分类号： A61K31/55 , A61K9/0073 , A61K9/205 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K2800/56
摘要： Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise solubility- and/or release enhancing agents to provide tailored drug release profiles, preferably sigmoidal release profiles. Methods of treatment comprising the inventive compositions are also disclosed.
-
公开(公告)号：US20230381191A1
公开(公告)日：2023-11-30
申请号：US18232716
申请日：2023-08-10
CPC分类号： A61K31/5375 , A61K9/00 , A61K9/485 , A61K9/4866 , A61K9/146 , A61K9/2054 , A61K9/50
摘要： Modified release formulations of viloxazine and methods of administering the same are disclosed. High-drug load formulations of viloxazine are further disclosed.
-
公开(公告)号：US20230355589A1
公开(公告)日：2023-11-09
申请号：US18222681
申请日：2023-07-17
IPC分类号： A61K31/4188 , A61K31/00 , A61K9/00
CPC分类号： A61K31/4188 , A61K31/00 , A61K9/0053
摘要： The invention comprises a method of treatment of CNS disorders by a pharmaceutical agent exhibiting combined noradrenergic, serotonergic or dopaminergic reuptake transporter inhibitory and μ-opioid agonistic activity
-
公开(公告)号：US20230090653A1
公开(公告)日：2023-03-23
申请号：US17831955
申请日：2022-06-03
IPC分类号： A61K9/16 , A61P25/08 , A61K31/439
摘要： The present application discloses pharmaceutical compositions and methods of treating neurological disorders and seizure disorders with the high dose modified release compositions of huperzine. The pharmaceutical compositions and methods described herein, allow for higher dosing of huperzine, while avoiding rapid peak plasma levels, thereby avoiding the dose-limiting adverse events associated with the immediate release formulations.
-
公开(公告)号：US20230081113A1
公开(公告)日：2023-03-16
申请号：US17987655
申请日：2022-11-15
发明人： Padmanabh P. BHATT , Argaw KIDANE , Kevin EDWARDS
摘要： Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise solubility- and/or release enhancing agents to provide tailored drug release profiles, preferably sigmoidal release profiles. Methods of treatment comprising the inventive compositions are also disclosed.
-
公开(公告)号：US20220306618A1
公开(公告)日：2022-09-29
申请号：US17698592
申请日：2022-03-18
IPC分类号： C07D413/14 , C07D413/12 , C07D265/30
摘要： A compound of Formula I includes a stereoisomer thereof and/or a salt thereof; wherein R1 is a substituted alkane group, a heterocylic group, or a pyridine group; X is hydrogen, a halogen, an amino acid residue, a substituted amino acid residue, an alkyl group, or an ester. Such compounds may be used in pharmaceutical compositions and for the treatment of central nervous system (CNS) disorders:
-
公开(公告)号：US20220233548A1
公开(公告)日：2022-07-28
申请号：US17718819
申请日：2022-04-12
IPC分类号： A61K31/5375 , A61K31/00
摘要： The invention comprises a method for treatment of ADHD or ADHD-related disorders by a pharmaceutical agent exhibiting combined serotonergic or noradrenergic reuptake transporters and monoamine receptor activity.
-
公开(公告)号：US20220024885A1
公开(公告)日：2022-01-27
申请号：US17393834
申请日：2021-08-04
发明人： Likan LIANG , Padmanabh P. BHATT , David DAIN , Jean-Philippe TAQUET , Aleksandr PECHENOV , Alexei TCHESNOKOV , Reynold MARIAUX
IPC分类号： C07D265/30 , C07C217/34 , C07D265/32 , C07C215/08
摘要： Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.
-
公开(公告)号：US20210322429A1
公开(公告)日：2021-10-21
申请号：US17358920
申请日：2021-06-25
发明人： Rong-Kun Chang , Michael L. Vieira , Likan Liang , Padmanabh P. Bhatt , Austin B. Huang , Sachin V. Patel
摘要： Formulations of molindone having superior stability and methods of administering same are provided. The formulations may be immediate, modified, or otherwise delayed release formulations of molindone.
-
-
-
-
-
-
-
-
-
搜索结果
123 条记录 (耗时 0.026 秒)
