公开(公告)号：US4133886A

公开(公告)日：1979-01-09

申请号：US836627

申请日：1977-09-26

Applicant: Graham J. Durant ,  Charon R. Ganellin

Inventor： Graham J. Durant ,  Charon R. Ganellin

IPC: C07D231/12 ,  C07D233/54 ,  A61K31/44 ,  C07D213/78

CPC classification number: C07D233/64

Abstract: The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]propane. The compounds of this invention are inhibitors of H-2 histamine receptors.

公开(公告)号：US4129657A

公开(公告)日：1978-12-12

申请号：US869418

申请日：1978-01-16

Applicant: Graham J. Durant ,  John C. Emmett ,  Charon R. Ganellin

Inventor： Graham J. Durant ,  John C. Emmett ,  Charon R. Ganellin

IPC: C07D233/08 ,  C07D233/64 ,  C07D249/08 ,  C07D277/26 ,  A61K31/415

CPC classification number: C07D233/08

Abstract: The compounds are guanidines, for example N-benzenesulphonyl-N'-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidine, which are inhibitors of histamine activity.

Abstract translation: 化合物是胍，例如作为组胺活性抑制剂的N-苯磺酰基-N' - [2 - （（4-甲基-5-咪唑基） - 甲硫基）乙基]胍。

公开(公告)号：US4088769A

公开(公告)日：1978-05-09

申请号：US795254

申请日：1977-05-09

Applicant: James W. Black ,  Graham J. Durant ,  John C. Emmett ,  Charon R. Ganellin

Inventor： James W. Black ,  Graham J. Durant ,  John C. Emmett ,  Charon R. Ganellin

IPC: C07D209/48 ,  C07D213/40 ,  C07D231/12 ,  C07D233/24 ,  C07D233/26 ,  C07D233/54 ,  C07D249/08 ,  C07D277/28 ,  A61K31/415 ,  A61K31/425

CPC classification number: C07D277/28 ,  C07D209/48 ,  C07D213/40 ,  C07D231/12 ,  C07D233/24 ,  C07D233/26 ,  C07D233/64 ,  C07D249/08

Abstract: A method of inhibiting histamine activity, in particular inhibiting H-2 histamine receptors, by administering heterocyclicalkylguanidines.

Abstract translation: 通过施用杂环烷基胍来抑制组胺活性，特别是抑制H-2组胺受体的方法。