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公开(公告)号：US20200215162A1
公开(公告)日：2020-07-09
申请号：US16600722
申请日：2019-10-14
IPC分类号： A61K38/26 , A61M5/142 , A61K47/12 , A61K9/08 , A61K47/18 , A61M5/32 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/20 , A61K47/26 , A61K38/00 , A61K47/00
摘要： Certain embodiments are directed to a formulation of a therapeutic agent, as well as a method of making such a formulation, comprising at least one therapeutic agent dissolved in an aprotic polar solvent system comprising at least one ionization stabilizing excipient in a concentration sufficient to impart physical and chemical stability to the therapeutic agent.
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公开(公告)号：US20170312341A1
公开(公告)日：2017-11-02
申请号：US15594998
申请日：2017-05-15
IPC分类号： A61K38/26 , A61K47/26 , A61K47/20 , A61K47/12 , A61K47/10 , A61K47/02 , A61K47/00 , A61K38/00 , A61K9/08 , A61M5/142 , A61K9/00
CPC分类号： A61K38/26 , A61K9/0019 , A61K9/08 , A61K38/00 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/186 , A61K47/20 , A61K47/26 , A61M5/142 , A61M5/32
摘要： Certain embodiments are directed to a formulation of a therapeutic agent, as well as a method of making such a formulation, comprising at least one therapeutic agent dissolved in an aprotic polar solvent system comprising at least one ionization stabilizing excipient in a concentration sufficient to impart physical and chemical stability to the therapeutic agent.
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公开(公告)号：US20140349926A1
公开(公告)日：2014-11-27
申请号：US14354848
申请日：2012-10-31
发明人： Steven Prestrelski , Nancy Scott
摘要： Disclosed is a formulation for parenteral administration comprising insulin that comprises a pH memory between 1 to 4 or between 6 to 8 and an aprotic polar solvent, wherein the insulin is solubilized in the aprotic polar solvent, wherein the solubilized insulin comprises stable monomeric or dimeric forms of insulin or mixtures thereof, and wherein the water content of the formulation is equal to or less than 15% w/v.
摘要翻译： 公开了一种用于肠胃外给药的制剂，其包含含有1至4或6至8之间的pH记忆和非质子极性溶剂的胰岛素，其中所述胰岛素溶解在非质子极性溶剂中，其中所述溶解的胰岛素包含稳定的单体或二聚体形式 的胰岛素或其混合物，并且其中制剂的水含量等于或小于15％w / v。
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公开(公告)号：US10987399B2
公开(公告)日：2021-04-27
申请号：US15077633
申请日：2016-03-22
发明人： Steven Prestrelski , John Kinzell
IPC分类号： A61K38/02 , A61K38/16 , A61P3/10 , A61P3/08 , A61K47/26 , A61K47/36 , A61K9/00 , A61K9/19 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K38/17 , A61K38/22 , A61K38/26 , A61K47/02 , A61K47/18 , A61K38/09 , A61K38/18 , A61K38/25 , A61K38/30 , A61K38/48 , A61K9/08 , A61K38/28 , A61K47/22 , A61K38/29
摘要： Stable formulations for parenteral injection of peptide drugs and methods of using such stable formulations are provided. In particular, the present invention provides stable formulations for parenteral injection of glucagon and methods of using such glucagon formulations to treat hypoglycemia, especially severe hypoglycemia in emergency situations.
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公开(公告)号：US09138479B2
公开(公告)日：2015-09-22
申请号：US14354848
申请日：2012-10-31
发明人： Steven Prestrelski
摘要： Disclosed is a formulation for parenteral administration comprising insulin that comprises a pH memory between 1 to 4 or between 6 to 8 and an aprotic polar solvent, wherein the insulin is solubilized in the aprotic polar solvent, wherein the solubilized insulin comprises stable monomeric or dimeric forms of insulin or mixtures thereof, and wherein the water content of the formulation is equal to or less than 15% w/v.
摘要翻译： 公开了一种用于肠胃外给药的制剂，其包含含有1至4或6至8之间的pH记忆和非质子极性溶剂的胰岛素，其中所述胰岛素溶解在非质子极性溶剂中，其中所述溶解的胰岛素包含稳定的单体或二聚体形式 的胰岛素或其混合物，并且其中制剂的水含量等于或小于15％w / v。
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公开(公告)号：US20170087215A1
公开(公告)日：2017-03-30
申请号：US15136650
申请日：2016-04-22
CPC分类号： A61K38/26 , A61K9/0019 , A61K9/08 , A61K38/00 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/186 , A61K47/20 , A61K47/26 , A61M5/142
摘要： Certain embodiments are directed to a formulation of a therapeutic agent, as well as a method of making such a formulation, comprising at least one therapeutic agent dissolved in an aprotic polar solvent system comprising at least one ionization stabilizing excipient in a concentration sufficient to impart physical and chemical stability to the therapeutic agent.
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公开(公告)号：US09339545B2
公开(公告)日：2016-05-17
申请号：US14192697
申请日：2014-02-27
发明人： Steven Prestrelski , John Kinzell
IPC分类号： A61K47/22 , A61K47/20 , A61K38/26 , A61K47/26 , A61K9/00 , A61K9/19 , A61K38/22 , A61K38/28 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K38/09 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/25 , A61K38/29 , A61K38/30 , A61K38/48
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/19 , A61K38/02 , A61K38/09 , A61K38/16 , A61K38/17 , A61K38/1709 , A61K38/1816 , A61K38/22 , A61K38/2207 , A61K38/25 , A61K38/26 , A61K38/29 , A61K38/30 , A61K38/4893 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/36
摘要： Stable formulations for parenteral injection of peptide drugs and methods of using such stable formulations are provided. In particular, the present invention provides stable formulations for parenteral injection of glucagon and methods of using such glucagon formulations to treat hypoglycemia, especially severe hypoglycemia in emergency situations.
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公开(公告)号：US09302010B2
公开(公告)日：2016-04-05
申请号：US14188464
申请日：2014-02-24
发明人： Steven Prestrelski , John Kinzell
IPC分类号： A61K38/29 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/26 , A61K9/00 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/22 , A61K38/09 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/25 , A61K38/30 , A61K38/48
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/19 , A61K38/02 , A61K38/09 , A61K38/16 , A61K38/17 , A61K38/1709 , A61K38/1816 , A61K38/22 , A61K38/2207 , A61K38/25 , A61K38/26 , A61K38/29 , A61K38/30 , A61K38/4893 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/36
摘要： Stable formulations for parenteral injection of peptide drugs and methods of using such stable formulations are provided. In particular, the present invention provides stable formulations for parenteral injection of glucagon and methods of using such glucagon formulations to treat hypoglycemia, especially severe hypoglycemia in emergency situations.
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公开(公告)号：US20140179599A1
公开(公告)日：2014-06-26
申请号：US14192679
申请日：2014-02-27
发明人： Steven Prestrelski , John Kinzell
IPC分类号： A61K47/22 , A61K47/18 , A61K47/20 , A61K47/26 , A61K47/12 , A61K47/14 , A61K47/10 , A61K38/26 , A61K47/02
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/19 , A61K38/02 , A61K38/09 , A61K38/16 , A61K38/17 , A61K38/1709 , A61K38/1816 , A61K38/22 , A61K38/2207 , A61K38/25 , A61K38/26 , A61K38/29 , A61K38/30 , A61K38/4893 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/36
摘要： Stable formulations for parenteral injection of peptide drugs and methods of using such stable formulations are provided. In particular, the present invention provides stable formulations for parenteral injection of glucagon and methods of using such glucagon formulations to treat hypoglycemia, especially severe hypoglycemia in emergency situations.
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公开(公告)号：US09649364B2
公开(公告)日：2017-05-16
申请号：US15136650
申请日：2016-04-22
IPC分类号： A61K38/26 , C07K14/605 , A61P3/00 , A61K47/02 , A61K47/20 , A61K47/10 , A61K47/26 , A61K9/00
CPC分类号： A61K38/26 , A61K9/0019 , A61K9/08 , A61K38/00 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/186 , A61K47/20 , A61K47/26 , A61M5/142
摘要： Certain embodiments are directed to a formulation of a therapeutic agent, as well as a method of making such a formulation, comprising at least one therapeutic agent dissolved in an aprotic polar solvent system comprising at least one ionization stabilizing excipient in a concentration sufficient to impart physical and chemical stability to the therapeutic agent.
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