FORMULATIONS FOR THE TREATMENT OF DIABETES
    3.
    发明申请
    FORMULATIONS FOR THE TREATMENT OF DIABETES 有权
    治疗糖尿病的配方

    公开(公告)号:US20140349926A1

    公开(公告)日:2014-11-27

    申请号:US14354848

    申请日:2012-10-31

    IPC分类号: A61K47/20 A61K38/22 A61K38/28

    摘要: Disclosed is a formulation for parenteral administration comprising insulin that comprises a pH memory between 1 to 4 or between 6 to 8 and an aprotic polar solvent, wherein the insulin is solubilized in the aprotic polar solvent, wherein the solubilized insulin comprises stable monomeric or dimeric forms of insulin or mixtures thereof, and wherein the water content of the formulation is equal to or less than 15% w/v.

    摘要翻译: 公开了一种用于肠胃外给药的制剂,其包含含有1至4或6至8之间的pH记忆和非质子极性溶剂的胰岛素,其中所述胰岛素溶解在非质子极性溶剂中,其中所述溶解的胰岛素包含稳定的单体或二聚体形式 的胰岛素或其混合物,并且其中制剂的水含量等于或小于15%w / v。

    Formulations for the treatment of diabetes
    5.
    发明授权
    Formulations for the treatment of diabetes 有权
    治疗糖尿病的制剂

    公开(公告)号:US09138479B2

    公开(公告)日:2015-09-22

    申请号:US14354848

    申请日:2012-10-31

    摘要: Disclosed is a formulation for parenteral administration comprising insulin that comprises a pH memory between 1 to 4 or between 6 to 8 and an aprotic polar solvent, wherein the insulin is solubilized in the aprotic polar solvent, wherein the solubilized insulin comprises stable monomeric or dimeric forms of insulin or mixtures thereof, and wherein the water content of the formulation is equal to or less than 15% w/v.

    摘要翻译: 公开了一种用于肠胃外给药的制剂,其包含含有1至4或6至8之间的pH记忆和非质子极性溶剂的胰岛素,其中所述胰岛素溶解在非质子极性溶剂中,其中所述溶解的胰岛素包含稳定的单体或二聚体形式 的胰岛素或其混合物,并且其中制剂的水含量等于或小于15%w / v。