公开(公告)号：US20240280467A1

公开(公告)日：2024-08-22

申请号：US18571582

申请日：2022-06-17

Applicant: ThinkCyte K.K. ,  The University of Tokyo

Inventor： Hiroaki Adachi ,  Sadao Ota

IPC: G01N15/1433 ,  G01N15/149 ,  G06V10/764

CPC classification number: G01N15/1433 ,  G01N15/149 ,  G06V10/764

Abstract: First waveform data, which indicates the morphological characteristics of a particle and is obtained by emitting light to the particle, and a photographic image obtained by photographing the particle are acquired. A first trained model that outputs a particle image when waveform data is input is generated by training using first training data including the first waveform data and the photographic image. Second waveform data is input to the first trained model. Classification information indicating a classification into which the particle is classified according to the morphological characteristics is acquired in association with the particle image output from the first trained model. Data including the second waveform data and the classification information is stored as second training data for training a second trained model that outputs classification information when waveform data is input.

公开(公告)号：US20240241031A1

公开(公告)日：2024-07-18

申请号：US18688948

申请日：2022-08-29

Applicant: ThinkCyte K.K. ,  The University of Tokyo

Inventor： Hiroaki Adachi ,  Issei Sato

IPC: G01N15/1429 ,  G01N15/01 ,  G01N15/10 ,  G01N15/1434 ,  G01N15/149

CPC classification number: G01N15/1429 ,  G01N15/01 ,  G01N15/1434 ,  G01N15/149 ,  G01N2015/1006

Abstract: In the classification model generation method, for each particle contained in a first sample containing a mixture of particles having specific morphological characteristics and other particles and a second sample that does not contain particles having the specific morphological characteristics but contains only the other particles, observation data indicating a result of observing the particle is acquired. By training using training data including the observation data and information indicating whether the observation data has been obtained from a particle contained in the first sample or the second sample, a classification model is generated that outputs discrimination information indicating whether or not a particle has the specific morphological characteristics when the observation data indicating a result of observing the particle is input.

公开(公告)号：US20250044211A1

公开(公告)日：2025-02-06

申请号：US18800748

申请日：2024-08-12

Applicant: ThinkCyte K.K.

Inventor： Toru Imai ,  Hiroaki Adachi

IPC: G01N15/1404 ,  G01N15/14 ,  G01N15/1434

Abstract: A flow cytometer includes a microfluidic device, a light source, a photodetector that detects, in time series, the intensity of signal light emitted from an observation object when the observation object flowing through a flow path is irradiated with illumination light, an information generation device that generates optical information indicating a structure of the observation object based on the intensity of the signal light, an arithmetic device, and a flow path position control device, wherein the arithmetic device includes a signal intensity acquiring unit that acquires electronic data of temporal changes in the intensity of the signal light detected based on a detection position predetermined in the flow path to detect the depth position in the flow path where the observation object passes through the flow path, a scan unit that performs a scan process to move the flow path in the depth direction and acquire the electronic data at different depth positions, a position calculation unit that calculates the depth position based on the electronic data, and an output unit that outputs position information indicating the depth position calculated by the position calculation unit.

公开(公告)号：US20230266229A1

公开(公告)日：2023-08-24

申请号：US18118670

申请日：2023-03-07

Applicant: ThinkCyte K.K.

Inventor： Toru Imai ,  Hiroaki Adachi ,  Keisuke Toda

IPC: G01N15/14

CPC classification number: G01N15/1459 ,  G01N15/1484 ,  G01N15/1436 ,  G01N2015/1006

Abstract: A flow cytometer includes: a light source; a microfluidic device; a photodetector; an information generation device which generates optical information indicating a morphology of an observation target on the basis of optical signal intensity; and a spatial light modulation unit which is installed on an optical path between the light source and the photodetector and structures any one of illumination light irradiated from the light source toward the flow path and signal light from the observation target. In the flow path provided with the microfluidic device, a plurality of optical signal detection positions are arranged linearly at equal intervals in a predetermined direction of the flow path by structuring the illumination light or the signal light and a plurality of trigger signal detection positions for detecting a trigger signal by which the information generation device starts the generation of the optical information are arranged to be separated by the same predetermined distance in a length direction of the flow path while respectively corresponding to the plurality of optical signal detection positions.