公开(公告)号：US09509956B2

公开(公告)日：2016-11-29

申请号：US13670954

申请日：2012-11-07

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Rafael Piestun ,  Donald Conkey

IPC: H04N7/18 ,  G02B26/06 ,  G01N21/47

CPC classification number: H04N7/18 ,  G01N21/4795 ,  G02B26/06

Abstract: A wavefront is optimized imaging a sample. A binary off-axis hologram is encoded by selective adoption of states for each mirror of a deformable mirror device, which is illuminated with an incident beam of light. A single diffraction order that has encoded phase-mask information is selected from light reflected from the deformable mirror device and focused onto the sample. Light scattered from the sample is directed to a photodetector. A transmission matrix through the sample is calculated from light received by the photodetector.

Abstract translation: 波前优化成像样本。 通过选择性地采用用入射光束照射的可变形反射镜装置的每个反射镜的状态来编码二进制离轴全息图。 已经编码相位掩模信息的单个衍射顺序是从可变形反射镜装置反射的光中选出并聚焦到样品上。 从样品散射的光被引导到光电检测器。 通过光电检测器接收的光计算通过样品的透射矩阵。

公开(公告)号：US20160356746A1

公开(公告)日：2016-12-08

申请号：US14913958

申请日：2014-08-26

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Rafael Piestun ,  Hengyi Ju ,  Jacob Dove ,  Antonio Miguel Caravacca-Aguirre ,  Todd Murray ,  Donald Conkey

IPC: G01N29/24 ,  G01N29/06

CPC classification number: G01N29/2418 ,  A61B5/0095 ,  G01N21/1702 ,  G01N29/0654 ,  G01N2021/1706 ,  G01N2201/0675

Abstract: Systems and methods are disclosed to enhance three-dimensional photoacoustic imaging behind, through, or inside a scattering material. Embodiments of the invention can increase the optical fluence in an ultrasound transducer focus and/or enhance the optical intensity using wavefront shaping before the scatterer. The photoacoustic signal induced by an object placed behind the scattering medium can serve as feedback to optimize the wavefront, enabling one order of magnitude enhancement of the photoacoustic amplitude. Using the enhanced optical intensity, the object can be scanned in two dimensions and/or a spot can be scanned by re-optimizing the wavefront before post-processing of the data to reconstruct the image. The temporal photoacoustic signal provides information to reconstruct the third-dimensional information.

Abstract translation: 公开了系统和方法来增强散射材料后面，通过或内部的三维光声成像。 本发明的实施例可以在散射体之前使用波前整形来增加超声波换能器焦点中的光能密度和/或增强光强度。 由放置在散射介质后面的物体引起的光声信号可以用作反馈以优化波前，使光声振幅能够提高一个数量级。 使用增强的光强度，可以在二维扫描物体和/或可以在对数据进行后处理以重构图像之前重新优化波阵面来扫描点。 时间光声信号提供重建第三维信息的信息。

公开(公告)号：US10036735B2

公开(公告)日：2018-07-31

申请号：US14913958

申请日：2014-08-26

Applicant: The Regents of The University of Colorado, A Body Corporate

Inventor： Rafael Piestun ,  Hengyi Ju ,  Jacob Dove ,  Antonio Miguel Caravaca-Aguirre ,  Todd Murray ,  Donald Conkey

IPC: G01N29/44 ,  G01N21/00 ,  G01N29/24 ,  A61B5/00 ,  G01N21/17 ,  G01N29/06

CPC classification number: G01N29/2418 ,  A61B5/0095 ,  G01N21/1702 ,  G01N29/0654 ,  G01N2021/1706 ,  G01N2201/0675

Abstract: Systems and methods are disclosed to enhance three-dimensional photoacoustic imaging behind, through, or inside a scattering material. Some embodiments can increase the optical fluence in an ultrasound transducer focus and/or enhance the optical intensity using wavefront shaping before the scatterer. The photoacoustic signal induced by an object placed behind the scattering medium can serve as feedback to optimize the wavefront, enabling one order of magnitude enhancement of the photoacoustic amplitude. Using the enhanced optical intensity, the object can be scanned in two dimensions and/or a spot can be scanned by re-optimizing the wavefront before post-processing of the data to reconstruct the image. The temporal photoacoustic signal provides information to reconstruct the third-dimensional information.