公开(公告)号：US11084847B2

公开(公告)日：2021-08-10

申请号：US16321430

申请日：2017-09-22

Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

Inventor： Jiaqiang Cai ,  Qiang Tian ,  Mingliang Zhao ,  Hong Zeng ,  Hongmei Song ,  Nan Yu ,  Hua Deng ,  Wei Zhong ,  Long Yang ,  Lei Wu ,  Haitao Huang ,  Yongyong Wu ,  Donghai Su ,  Xin Zhou ,  Yuting Tan ,  Lichun Wang ,  Jingyi Wang

IPC: C07K5/107 ,  A61P23/00 ,  A61K38/00

Abstract: The invention relates to a polyamide compound and a use thereof. Specifically, the invention relates to a type of polyamide compound (which preferably comprise one or more amide bonds formed by condensation of same or different L-amino acids or D-amino acids), or stereoisomers, crystalline polymorphs, solvates, metabolites, prodrugs or pharmaceutically acceptable salts or esters thereof, or pharmaceutical compositions thereof, as well as a method for preparing the polyamide compound and a use thereof in the prevention or treatment of diseases associated with κ-opioid receptor. The polyamide compound of the invention has excellent κ-opioid receptor agonistic activity and hydrophilicity, thus having a lesser ability of penetrating the blood-brain barrier and a lower capacity for entering the brain. The compound of the invention has higher selectivity for a κ-opioid receptor, lower addictiveness, improved pharmacokinetic properties, and improved safety (lower toxicity and/or fewer side effects), good patient compliance, and/or lesser propensity for developing tolerance, among other excellent medicinal properties.

公开(公告)号：US10899786B2

公开(公告)日：2021-01-26

申请号：US16344317

申请日：2017-12-19

Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

Inventor： Jiaqiang Cai ,  Shuai Song ,  Qiang Tian ,  Yitao Zhang ,  Haitao Huang ,  Guoqing Zhong ,  Wei Zhong ,  Yongjia Hao ,  Mingliang Zhao ,  Hong Zeng ,  Hongmei Song ,  Xin Zhou ,  Yao Liu ,  Yuting Tan ,  Lichun Wang ,  Jingyi Wang

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/10 ,  A61P1/16 ,  C07H1/02

Abstract: Provided in the present invention are a compound of Formula (I), a pharmaceutical composition comprising the same, a method for preparing the same, and use thereof as a NS5B polymerase inhibitor, a DNA polymerase inhibitor or a reverse transcriptase inhibitor for the prevention or treatment of viral diseases or cancers.