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公开(公告)号：US11199690B2
公开(公告)日：2021-12-14
申请号：US16851410
申请日：2020-04-17
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo Eshel , Natalie Lezmy , Dan Gluck , Arnon Houri Yafin , Joseph Joel Pollak
Abstract: Apparatus and methods are described including acquiring microscopic images of a blood sample, and identifying deformed red blood cells within the microscopic images. A degree of red blood cell deformity within the sample is determined, at least partially based upon the identified deformed red blood cells. A sample-informative parameter that is indicative of a characteristic of the blood sample as a whole is determined, at least partially based upon the degree of red blood cell deformity within the sample. Other applications are also described.
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公开(公告)号：US12196664B2
公开(公告)日：2025-01-14
申请号：US18203109
申请日：2023-05-30
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo Eshel , Arnon Houri Yafin , Joseph Joel Pollak , Neta Bachar , Annael Marciano , Sarah Levy Schreier
Abstract: Apparatus and methods are described for use with an output device, and a blood sample that was drawn from a subject. A microscope system acquires first and second images of the blood sample at respective times. A computer processor determines whether, between acquisitions of the first and second images, there was relative motion between at least one erythrocyte within the sample and at least one entity within the sample, by comparing the first and second images to one another. At least partially in response thereto, the computer processor determines whether the entity is an extra-erythrocytic or an intra-erythrocytic entity, and generates an output on the output device, at least partially in response thereto. Other applications are also described.
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公开(公告)号：US11914133B2
公开(公告)日：2024-02-27
申请号：US17568858
申请日：2022-01-05
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo Eshel , Natalie Lezmy , Dan Gluck , Arnon Houri Yafin , Joseph Joel Pollak
CPC classification number: G02B21/367 , G01N21/8851 , G02B21/365 , G06T7/0012 , G06V20/693 , G06V20/698 , G01N2021/8887 , G06T2207/10056 , G06T2207/30024 , G06T2207/30101
Abstract: Apparatus and methods are described for analyzing a bodily sample. A microscope system acquires one or more microscope images of the bodily sample. A computer processor identifies elements as being candidates of a given entity, in the one or more images. At least one sample-informative feature, relating to a characteristic of the candidates of the given entity in the sample as a whole, is extracted from the one or more images. A characteristic of the sample is determined at least partially based upon the sample-informative feature, and an output is generated in response thereto. Other applications are also described.
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公开(公告)号：US20200249458A1
公开(公告)日：2020-08-06
申请号：US16851410
申请日：2020-04-17
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie Lezmy , Dan Gluck , Arnon Houri Yafin , Joseph Joel Pollak
Abstract: Apparatus and methods are described including acquiring microscopic images of a blood sample, and identifying deformed red blood cells within the microscopic images. A degree of red blood cell deformity within the sample is determined, at least partially based upon the identified deformed red blood cells. A sample-informative parameter that is indicative of a characteristic of the blood sample as a whole is determined, at least partially based upon the degree of red blood cell deformity within the sample. Other applications are also described.
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公开(公告)号：US11733150B2
公开(公告)日：2023-08-22
申请号：US16088321
申请日：2017-03-23
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo Eshel , Arnon Houri Yafin , Joseph Joel Pollak , Neta Bachar , Annael Marciano , Sarah Levy Schreier
CPC classification number: G01N15/1475 , G01N1/30 , G01N33/49 , G02B21/367 , G01N2015/1006 , G06V20/698
Abstract: Apparatus and methods are described for use with an output device (34), and a blood sample (12) that was drawn from a subject. A microscope system (10) acquires first and second images of the blood sample at respective times. A computer processor (28) determines whether, between acquisitions of the first and second images, there was relative motion between at least one erythrocyte within the sample and at least one entity within the sample, by comparing the first and second images to one another. At least partially in response thereto, the computer processor determines whether the entity is an extra-erythrocytic or an intra-erythrocytic entity, and generates an output on the output device, at least partially in response thereto. Other applications are also described.
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Patent Agency Ranking
公开(公告)号：US11434515B2
公开(公告)日：2022-09-06
申请号：US16106085
申请日：2018-08-21
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel Pollak , Arnon Houri Yafin , Seth J. Salpeter
Abstract: Apparatus and methods are described including introducing a cell suspension comprising red blood cells into a carrier that is a closed cavity that includes a base surface, via an inlet defined by the carrier. The cells in the cell suspension are allowed to settle on the base surface of the carrier to form a monolayer of cells on the base surface of the carrier. At least one microscope image of at least a portion of the monolayer of cells is acquired. Other applications are also described.
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公开(公告)号：US20210325373A1
公开(公告)日：2021-10-21
申请号：US17360503
申请日：2021-06-28
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir Zait , Arnon Houri Yafin , Dan Gluck , Sharon Pecker , Yochay Shlomo Eshel , Sarah Levy Schreier , Joseph Joel Pollak
IPC: G01N33/50 , G01N33/49 , G01N33/72 , G01N15/06 , G01N33/569
Abstract: Apparatus and methods are described including measuring hematocrit within a blood sample, by performing a first measurement on a first portion of the blood sample. Mean corpuscular volume in the blood sample is measured, by performing a second measurement on a second portion of the blood sample, the second portion being diluted with respect to the first portion. A red blood cell count per unit volume within the blood sample is determined by dividing the hematocrit measured within the first portion by the mean corpuscular volume measured within the second portion. Other applications are also described.
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公开(公告)号：US20200181680A1
公开(公告)日：2020-06-11
申请号：US16705941
申请日：2019-12-06
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Joseph Joel Pollak , Daniel Levner , Yonatan Bilu , Arnon Houri Yafin , Noam Yorav-Raphael , Yuval Greenfield
Abstract: Apparatus and methods for use with a blood sample are described. The blood sample is stained with Hoechst stain and Acridine Orange stain. A plurality of images of the blood sample are acquired. An object is identified as being a white blood cell candidate. A first stained area, which is stained by the Hoechst stain and which is disposed within the white blood cell candidate, is identified. A second stained area, which is stained by the Acridine Orange stain and which is disposed within the white blood cell candidate, is identified. A white blood cell is detected by determining that structural features of the stained areas satisfy predetermined criteria associated with a white blood cell. Other applications are also described.
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公开(公告)号：US09329129B2
公开(公告)日：2016-05-03
申请号：US14440864
申请日：2014-06-30
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel Pollak , Arnon Houri Yafin , Seth J. Salpeter
CPC classification number: C12Q1/04 , G01N1/2813 , G01N1/38 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6486 , G01N33/49 , G01N2015/0065 , G01N2021/6439 , G02B21/361
Abstract: Provided is a method for imaging a blood sample and a kit and system for executing the method. The method includes introducing a cell suspension including red blood cells onto a base surface of a carrier having a vertical height (H) being greater than or equal to a vertical depth (h) of the cell suspension when on the base carrier, the cell suspension including a cell concentration (C) being determined by a defined function; allowing the cells in the cell suspension to settle on the base surface of the carrier to form a monolayer of cells thereon; and acquiring at least one microscope image of at least a portion of the monolayer of cells; wherein the at least one microscope image is obtained by a microscope set to Depth Of Field that is not more than 20% of the vertical height of the cell suspension settled on the base surface.
Abstract translation: 提供了一种用于对血液样本进行成像的方法以及用于执行该方法的套件和系统。 该方法包括在载体的基底表面上引入包含红细胞的细胞悬浮液，所述载体的垂直高度（H）大于或等于细胞悬液的垂直深度（h） 包括由定义的功能确定的细胞浓度（C）; 允许细胞悬浮液中的细胞沉淀在载体的基底表面上以在其上形成单层细胞; 以及获取细胞单层的至少一部分的至少一个显微镜图像; 其中所述至少一个显微镜图像是通过设置在深度不到所述细胞悬液沉降在所述基面上的垂直高度的20％的显微镜得到的。
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公开(公告)号：US12174175B2
公开(公告)日：2024-12-24
申请号：US17082615
申请日：2020-10-28
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir Zait , Arnon Houri Yafin , Dan Gluck , Sharon Pecker , Yochay Shlomo Eshel , Sarah Levy Schreier , Joseph Joel Pollak
Abstract: Apparatus and methods are described including placing a first portion of a biological sample into a source sample portion chamber of a sample carrier, and placing a second portion of the biological sample into a diluted sample portion chamber. The second portion of the biological sample is diluted with respect to the first portion of the biological sample. Using an optical measurement device, a bulk-level measurand of the sample that relates to a parameter of the biological sample as a whole is measured, by performing a measurement upon the first portion of the biological sample. Microscopic images of the second portion of the biological sample are acquired. Other applications are also described.
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