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公开(公告)号：US20220389006A1
公开(公告)日：2022-12-08
申请号：US17755562
申请日：2020-11-02
发明人： Peter Qinhua Huang , Sayee Gajanan Hegde , Kevin Duane Bunker , John Knight , Deborah Helen Slee
IPC分类号： C07D471/04
摘要： Salts of Compound A and forms described herein are estrogen receptor alpha modulators. Such salts and/or forms can be are useful for treating diseases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions characterized by excessive cellular proliferation, such as breast cancer.
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公开(公告)号：US20210330651A1
公开(公告)日：2021-10-28
申请号：US17305369
申请日：2021-07-06
发明人： Peter Qinhua Huang , Deborah Helen Slee , Sayee Gajanan Hegde , Chad Daniel Hopkins , Kevin Duane Bunker , Joseph Robert Pinchman , Rakesh Kumar Sit
IPC分类号： A61K31/438 , A61K31/437 , A61P5/30 , A61P35/00 , C07B59/00 , C07C69/738 , C07C69/757 , C07D209/10 , C07D471/04 , C07C69/732
摘要： Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described in the disclosure. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions characterized by excessive cellular proliferation, such as breast cancer.
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公开(公告)号：US11065234B2
公开(公告)日：2021-07-20
申请号：US16867017
申请日：2020-05-05
发明人： Peter Qinhua Huang , Deborah Helen Slee , Sayee Gajanan Hegde , Chad Daniel Hopkins , Kevin Duane Bunker , Joseph Robert Pinchman , Rakesh Kumar Sit
IPC分类号： A61K31/437 , A61K31/438 , C07C69/738 , C07C69/732 , C07D471/04 , C07B59/00 , C07C69/757 , C07D209/10 , A61P5/30 , A61P35/00
摘要： Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described in the disclosure. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions characterized by excessive cellular proliferation, such as breast cancer.
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公开(公告)号：US20210094899A1
公开(公告)日：2021-04-01
申请号：US16634366
申请日：2018-07-26
发明人： Peter Qinhua Huang , Deborah Helen Slee , Kevin Duane Bunker , Sayee Gajanan Hegde , Chad Daniel Hopkins
IPC分类号： C07C59/56 , C07C255/57 , A61P35/00
摘要： Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
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公开(公告)号：US12049460B2
公开(公告)日：2024-07-30
申请号：US17445280
申请日：2021-08-17
发明人： Kevin Duane Bunker , Peter Qinhua Huang , Sunny Abraham , Joseph Robert Pinchman , Chad Daniel Hopkins , Deborah Helen Slee
IPC分类号： C07D403/04 , A61K31/506 , A61P35/00 , C07C13/36 , C07D209/04 , C07D403/14 , C07D471/04
CPC分类号： C07D403/04 , A61K31/506 , A61P35/00 , C07C13/36 , C07D209/04 , C07D403/14 , C07D471/04
摘要： Disclosed herein are nitrogen-containing bicyclic compounds of Formula (I), including pharmaceutically acceptable salts thereof, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.
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公开(公告)号：US11242327B2
公开(公告)日：2022-02-08
申请号：US16613397
申请日：2018-05-11
发明人： Chad Daniel Hopkins , Joseph Robert Pinchman , Kevin Duane Bunker , Deborah Helen Slee , Brant Clayton Boren , Mehmet Kahraman
IPC分类号： C07D277/28 , C07D213/38 , C07D235/14 , C07D239/26 , C07D263/56 , C07D277/64 , A61P29/00 , A61P25/04 , C07C211/38 , C07C211/40 , C07C215/08 , C07C217/52 , C07C229/14 , C07C235/14 , C07C237/04 , C07C271/24
摘要： Disclosed herein are compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), and methods of using compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It) as an analgesic.
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公开(公告)号：US11098030B2
公开(公告)日：2021-08-24
申请号：US16703544
申请日：2019-12-04
发明人： Kevin Duane Bunker , Peter Qinhua Huang , Sunny Abraham , Joseph Robert Pinchman , Chad Daniel Hopkins , Deborah Helen Slee
IPC分类号： C07D209/04 , C07C13/36 , C07D403/04 , A61P35/00 , A61K31/506 , C07D403/14 , C07D471/04
摘要： Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.
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公开(公告)号：US20200261430A1
公开(公告)日：2020-08-20
申请号：US16867017
申请日：2020-05-05
发明人： Peter Qinhua Huang , Deborah Helen Slee , Sayee Gajanan Hegde , Chad Daniel Hopkins , Kevin Duane Bunker , Joseph Robert Pinchman , Rakesh Kumar Sit
IPC分类号： A61K31/438 , C07C69/757 , C07B59/00 , C07D471/04 , C07C69/732 , C07C69/738 , A61K31/437 , A61P35/00 , A61P5/30
摘要： Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described in the disclosure. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions characterized by excessive cellular proliferation, such as breast cancer.
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公开(公告)号：US10525036B2
公开(公告)日：2020-01-07
申请号：US15563926
申请日：2016-03-31
发明人： Peter Qinhua Huang , Mehmet Kahraman , Deborah Helen Slee , Kevin Duane Bunker , Chad Daniel Hopkins , Joseph Robert Pinchman , Sunny Abraham , Rakesh Kumar Sit , Daniel Lee Severance
IPC分类号： C07D487/10 , A61K31/4162 , C07D471/10 , A61P35/00 , A61K31/416
摘要： Disclosed herein are spirocyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.
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公开(公告)号：US11065233B2
公开(公告)日：2021-07-20
申请号：US16866900
申请日：2020-05-05
发明人： Peter Qinhua Huang , Deborah Helen Slee , Sayee Gajanan Hegde , Chad Daniel Hopkins , Kevin Duane Bunker , Joseph Robert Pinchman , Rakesh Kumar Sit
IPC分类号： C07D471/04 , A61K31/438 , C07C69/738 , C07C69/732 , C07B59/00 , C07C69/757 , C07D209/10 , A61P5/30 , A61P35/00 , A61K31/437
摘要： Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described in the disclosure. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions characterized by excessive cellular proliferation, such as breast cancer.
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