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公开(公告)号：US20230302156A1
公开(公告)日：2023-09-28
申请号：US18011399
申请日：2021-06-22
Applicant: OHIO STATE INNOVATION FOUNDATION
Inventor： Pengfei JIANG , Katelyn Elizabeth REILLY
CPC classification number: A61K47/6933 , A61K9/0048 , A61P27/02
Abstract: The present disclosure relates to therapeutic compositions, and more particularly to redox-responsive nanoparticles that allow controlled release of therapeutics, such as vascular endothelial growth factor inhibitors, in body tissues such as in the eye.
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Patent Agency Ranking
2.发明公开公开(公告)号：US20230398063A1
公开(公告)日：2023-12-14
申请号：US18134247
申请日：2023-04-13
Applicant: Ohio State Innovation Foundation
Inventor： Pengfei JIANG , Katelyn Elizabeth REILLY , Matthew OHR
CPC classification number: A61K9/0048 , A61K9/0019 , A61K9/5146 , A61K9/5161 , C07K16/22 , C07K2317/24
Abstract: In one aspect, the disclosure relates to relates to compositions, devices, and processes for drug delivery to an eye. The disclosed drug delivery compositions comprise a particle having a core component comprising a first polymer and a therapeutic agent, and a shell layer surrounding the core component comprising a second polymer. In a further aspect, the present disclosure relates to methods of treating an ophthalmological disease or disorder. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US20250009755A1
公开(公告)日：2025-01-09
申请号：US18710916
申请日：2022-11-16
Applicant: Ohio State Innovation Foundation
Inventor： Andre PALMER , Katelyn Elizabeth REILLY , Megan ALLYN
IPC: A61K31/555 , A61K9/00 , A61K45/06 , A61K47/64 , A61P27/02
Abstract: Disclosed are ocular therapeutic compositions as well as methods for treating ocular diseases and injuries using these compositions.
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4.发明申请公开(公告)号：US20220117888A1
公开(公告)日：2022-04-21
申请号：US17428616
申请日：2020-02-10
Applicant: Ohio State Innovation Foundation
Inventor： Pengfei JIANG , Katelyn Elizabeth REILLY , Matthew P. OHR , John LANNUTTI
IPC: A61K9/00 , C08J5/18 , C08L67/04 , C08L5/08 , D01F8/10 , D01F8/14 , D01D5/00 , A61K45/06 , A61K39/395
Abstract: The present disclosure relates to compositions, devices, and methods for delivery of protein therapeutics, e.g., intravitreal delivery of a protein therapeutic to the eye. In particular, the present disclosure describes drug-delivery devices for injection into the eye of a subject in need thereof comprising a capsule having a bi-layered wall and a therapeutic agent, wherein the therapeutic agent is initially present within a luminal space of the capsule. Methods of making and using these drug-delivery devices are also described.
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公开(公告)号：US20220118159A1
公开(公告)日：2022-04-21
申请号：US17428617
申请日：2020-08-10
Applicant: Ohio State Innovation Foundation
Inventor： Katelyn Elizabeth REILLY , Matthew Aaron REILLY , Nguyen Khoi TRAM
IPC: A61L27/52 , C08L33/26 , C08F261/04 , A61L27/48 , A61L27/18
Abstract: In one aspect, the disclosure relates pertains to a vitreous substitute comprising a gel and an antioxidant, wherein the vitreous substitute mimics the physical properties of natural vitreous humor, as well as its methods of use in the treatment of ophthalmological disorders.
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公开(公告)号：US20210145736A1
公开(公告)日：2021-05-20
申请号：US17046639
申请日：2019-04-11
Applicant: Ohio State Innovation Foundation
Inventor： Pengfei JIANG , Katelyn Elizabeth REILLY , Matthew OHR
Abstract: In one aspect, the disclosure relates to relates to compositions, devices, and processes for drug delivery to an eye. The disclosed drug delivery compositions comprise a particle having a core component comprising a first polymer and a therapeutic agent, and a shell layer surrounding the core component comprising a second polymer. In a further aspect, the present disclosure relates to methods of treating an ophthalmological disease or disorder. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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