公开(公告)号：US20190285549A1

公开(公告)日：2019-09-19

申请号：US16429537

申请日：2019-06-03

Applicant: OLYMPUS CORPORATION

Inventor： Akira SATO

IPC: G01N21/65

Abstract: A Raman probe includes: a first illuminating fiber and a second illuminating fiber that are arranged in series and that are formed of different materials from each other; a coupling optical system for optically coupling the first and second illuminating fibers; a light-collecting fiber that is formed of the same material as the second illuminating fiber and that collects Raman scattered light from an examination subject; and an optical filter that is disposed between the first and second illuminating fibers and that selectively transmits a laser beam being guided by the first illuminating fiber and, of Raman scattered light of the first illuminating fiber excited by the laser beam, Raman scattered light the amount of Raman shift of which is smaller than a predetermined amount of Raman shift in a Raman spectrum of the examination subject.

公开(公告)号：US20160349181A1

公开(公告)日：2016-12-01

申请号：US15233230

申请日：2016-08-10

Applicant: OLYMPUS CORPORATION

Inventor： Akira SATO ,  Shinichi TAKIMOTO

IPC: G01N21/65 ,  G01J3/44 ,  G01J3/42

CPC classification number: G01N21/65 ,  G01J3/28 ,  G01J3/42 ,  G01J3/44 ,  G01N21/35 ,  G01N2201/1293

Abstract: With a spectroscopic analysis method of the present invention, by performing principal component analysis on optical spectra measured at individual positions of a specimen, principal components of a plurality of orders that constitute the individual optical spectra are calculated; for the individual orders, principal-component images in which values thereof are principal-component scores of the individual principal components corresponding to the positions are created; distribution patterns of the principal-component scores are identified in the individual principal-component images; the morphology of the specimen is identified in a morphological image in which the specimen is captured; the principal-component images that have principal-component-score distribution patterns correlated with the morphology of the specimen are identified; and the individual optical spectra are reconstructed by using the principal components of orders corresponding to the orders of the identified principal-component images.

Abstract translation: 利用本发明的光谱分析方法，通过对在试样的各个位置测定的光谱进行主成分分析，算出构成各个光谱的多个次序的主成分; 对于各个订单，产生其中其值为与位置对应的各个主要分量的主分量分数的主分量图像; 主成分分数的分布模式在各个主成分图像中被识别; 在其中捕获样本的形态图像中鉴定样品的形态; 确定了具有与样本形态相关的主分量分布模式的主成分图像; 并且通过使用与所识别的主分量图像的顺序相对应的次序的主成分来重建各个光谱。

公开(公告)号：US20210190686A1

公开(公告)日：2021-06-24

申请号：US17173332

申请日：2021-02-11

Applicant: OLYMPUS CORPORATION

Inventor： Shoichi KANEKO ,  Akira SATO ,  Chikashi OTA

IPC: G01N21/64 ,  G01N21/65

Abstract: Provided is a spectroscopic analysis apparatus including: an optical probe; and a spectroscopic analysis portion to which the optical probe is attached. The optical probe includes an optical fiber that guides illumination light coming from a light source and signal light coming from an observation target and an optical member that is disposed at least at a distal end of the optical fiber. The spectroscopic analysis portion includes an information separation portion that generates wavelength dependent characteristics by optically dispersing the signal light and that separates, from information about the signal light, information about first return light returning from the optical member and information about second return light returning from the optical fiber, a problem determining portion that determines a problem occurring at the optical probe based on the separated first return light and second return light, and a notification portion that notifies information about the determined problem.

公开(公告)号：US20160341657A1

公开(公告)日：2016-11-24

申请号：US15227086

申请日：2016-08-03

Applicant: OLYMPUS CORPORATION

Inventor： Akira SATO ,  Shinichi TAKIMOTO

IPC: G01N21/27 ,  G01J3/28

CPC classification number: G01N21/27 ,  G01J3/00 ,  G01J3/28 ,  G01J3/44 ,  G01J2003/283 ,  G01N21/65 ,  G01N2201/12

Abstract: A spectral measurement method of the present invention includes: a measuring step of measuring optical spectra of some sections specified among a plurality of sections on a specimen; a scalar-value calculating step of calculating, for individual measured sections, scalar values that represent information contained in the obtained optical spectra; an interpolating step of interpolating scalar values of unmeasured sections by using the calculated scalar values and by using two types of interpolation methods; an identifying step of identifying sections in which absolute values of differences between the two scalar values interpolated by using the two types of interpolation methods are equal to or greater than a predetermined threshold; and a repeating step of re-executing steps from the measuring step to the identifying step after specifying the identified sections.

Abstract translation: 本发明的光谱测量方法包括：测量步骤，测量在样本上的多个部分之间指定的一些部分的光谱; 标量值计算步骤，对于各个测量部分，计算表示所获得的光谱中包含的信息的标量值; 通过使用所计算的标量值和通过使用两种类型的插值方法来内插未测量部分的标量值的内插步骤; 识别步骤，用于识别通过使用两种类型的插值方法内插的两个标量值之间的差的绝对值等于或大于预定阈值的部分; 以及在指定所识别的部分之后重新执行从测量步骤到识别步骤的步骤的重复步骤。

公开(公告)号：US20170269071A1

公开(公告)日：2017-09-21

申请号：US15611265

申请日：2017-06-01

Applicant: OLYMPUS CORPORATION

Inventor： Akira SATO

IPC: G01N33/543

CPC classification number: G01N33/543 ,  C12Q1/00 ,  G01N1/4022 ,  G01N15/00 ,  G01N21/3563 ,  G01N21/552 ,  G01N21/554 ,  G01N21/658 ,  G01N2001/4027

Abstract: A liquid-sample component analysis method includes a dripping step of dripping a liquid sample onto a flat horizontal surface, a drying step of drying a liquid droplet of the liquid sample formed on the horizontal surface while keeping the liquid droplet still so as to obtain a plurality of concentrically-arranged ring-shaped deposits formed on the horizontal surface and composed of components having different particle diameters, and a measuring step of measuring a vibrational spectrum in each region including only one of the deposits so as to individually acquire vibrational spectra of the plurality of deposits.