公开(公告)号：US20110033495A1

公开(公告)日：2011-02-10

申请号：US12867622

申请日：2009-02-14

Applicant: Michael Roof ,  Marc Eichmeyer

Inventor： Michael Roof ,  Marc Eichmeyer

IPC: A61K39/295 ,  A61K39/12 ,  A61P31/04 ,  A61P31/20

CPC classification number: A61K39/12 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2750/10034

Abstract: The present invention relates to the use of an immunogenic composition that comprises a PCV2 antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with an enteric infection, even more preferably, with enteric disease. The use relates to a method comprising the steps of administering the composition to an animal in need thereof, preferably prior to disease exposure. Administration of PCV2 antigen, preferably ORF2 of PCV2, lessens the incidence and reduces the severity of the enteric disease.

Abstract translation: 本发明涉及包含用于治疗几种临床表现（疾病）的PCV2抗原的免疫原性组合物的用途。 优选地，临床表现与肠道感染相关，甚至更优选与肠道疾病相关。 该用途涉及包括以下步骤的方法：优选在疾病暴露之前将组合物施用于有需要的动物。 PCV2抗原，优选PCV2的ORF2的施用降低了发病率，降低了肠道疾病的严重性。

公开(公告)号：US09101561B2

公开(公告)日：2015-08-11

申请号：US13346134

申请日：2012-01-09

Applicant: Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel

Inventor： Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel

IPC: A61K39/04 ,  A61K38/00 ,  C07K14/005 ,  A61K49/00 ,  A61K39/12

CPC classification number: A61K39/12 ,  A61K38/00 ,  A61K39/04 ,  A61K49/0004 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K14/005 ,  C12N2750/10034 ,  C12N2750/14043 ,  C12N2770/10034

Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2ORF2 protein, and immunogenic compositions comprising PCV2ORF2 protein. Moreover, multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of PCV2 infection, preferably PCV2ORF2 protein, or an immunogenic composition comprising PCV2ORF2 protein, and at least one immunogenic active component of another disease-causing organism in swine.

Abstract translation: 提供了一种用于从猪圆环病毒2型开放阅读框架2回收蛋白质的改进方法。 还提供重组PCV2ORF2蛋白和包含PCV2ORF2蛋白的免疫原性组合物。 此外，提供了多价组合疫苗，其包括有效降低PCV2感染的发生率或降低PCV2感染的严重性的免疫学试剂，优选PCV2ORF2蛋白，或包含PCV2ORF2蛋白的免疫原性组合物，以及至少一种另外引起疾病的免疫原性活性成分 有机体在猪。

公开(公告)号：US07968285B2

公开(公告)日：2011-06-28

申请号：US12136923

申请日：2008-06-11

Applicant: Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

Inventor： Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

IPC: C12Q1/70

CPC classification number: A61K39/12 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2750/10022 ,  C12N2750/10023 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2750/10071 ,  C12N2750/14143

Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.

Abstract translation: 本发明涉及包含用于治疗几种临床表现（疾病）的猪圆环病毒2型（PCV2）抗原的免疫原性组合物的用途。 优选地，临床表现与PCV2感染相关。 优选地，它们包括淋巴结病，淋巴细胞减少和/或多核/巨细胞组织细胞。 此外，临床症状包括与猪中的一种或多种以下症状相结合的淋巴结病：（1）间质性肺炎与小叶间水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝脏，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia样病变，通常已知与细胞内劳森氏菌感染有关。

公开(公告)号：US20080279876A1

公开(公告)日：2008-11-13

申请号：US12137141

申请日：2008-06-11

Applicant: Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

Inventor： Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

IPC: A61K39/00

CPC classification number: A61K39/12 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2750/10022 ,  C12N2750/10023 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2750/10071 ,  C12N2750/14143

Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.

Abstract translation: 本发明涉及包含用于治疗几种临床表现（疾病）的猪圆环病毒2型（PCV2）抗原的免疫原性组合物的用途。 优选地，临床表现与PCV2感染相关。 优选地，它们包括淋巴结病，淋巴细胞减少和/或多核/巨细胞组织细胞。 此外，临床症状包括与猪中的一种或多种以下症状相结合的淋巴结病：（1）间质性肺炎与小叶间水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝脏，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia样病变，通常已知与细胞内劳森氏菌感染有关。

公开(公告)号：US20060035287A1

公开(公告)日：2006-02-16

申请号：US10918006

申请日：2004-08-13

Applicant: Jeremy Kroll ,  Michael Roof ,  Marc Eichmeyer

Inventor： Jeremy Kroll ,  Michael Roof ,  Marc Eichmeyer

IPC: G01N33/567 ,  G01N33/554 ,  G01N33/53 ,  G01N33/569

CPC classification number: G01N33/56911 ,  G01N2469/20

Abstract: Improved immunoassays for the protection of antibodies against Lawsonia intracellularis are provided which permit rapid, easy detection of low concentrations of anti-Lawsonia antibodies in animal-derived specimens. The preferred assay is an ELISA assay employing an antigenic extract of L. intracellularis lipopolysaccharide.

公开(公告)号：US09011868B2

公开(公告)日：2015-04-21

申请号：US13106606

申请日：2011-05-12

Applicant: Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

Inventor： Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

IPC: A61K39/12 ,  A61P31/12 ,  A61P37/04 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2750/10022 ,  C12N2750/10023 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2750/10071 ,  C12N2750/14143

Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.

Abstract translation: 本发明涉及包含用于治疗几种临床表现（疾病）的猪圆环病毒2型（PCV2）抗原的免疫原性组合物的用途。 优选地，临床表现与PCV2感染相关。 优选地，它们包括淋巴结病，淋巴细胞减少和/或多核/巨细胞组织细胞。 此外，临床症状包括与猪中的一种或多种以下症状相结合的淋巴结病：（1）间质性肺炎与小叶间水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝脏，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia样病变，通常已知与细胞内劳森氏菌感染有关。

公开(公告)号：US08119143B2

公开(公告)日：2012-02-21

申请号：US12137184

申请日：2008-06-11

Applicant: Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel

Inventor： Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel

IPC: A61K39/12

CPC classification number: A61K39/12 ,  A61K38/00 ,  A61K39/04 ,  A61K49/0004 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K14/005 ,  C12N2750/10034 ,  C12N2750/14043 ,  C12N2770/10034

Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein. Moreover, multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of PCV2 infection, preferably PCV2 ORF2 protein, or an immunogenic composition comprising PCV2 ORF2 protein, and at least one immunogenic active component of another disease-causing organism in swine.

Abstract translation: 提供了一种用于从猪圆环病毒2型开放阅读框架2回收蛋白质的改进方法。 还提供重组PCV2 ORF2蛋白和包含PCV2 ORF2蛋白的免疫原性组合物。 此外，提供了多价组合疫苗，其包括有效降低PCV2感染的严重性（优选PCV2 ORF2蛋白）或包含PCV2 ORF2蛋白的免疫原性组合物的发生率或降低的免疫学试剂，以及至少一种其它疾病的免疫原性活性成分 在猪中有机体。

公开(公告)号：US20090092636A1

公开(公告)日：2009-04-09

申请号：US12137184

申请日：2008-06-11

Applicant: Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel

Inventor： Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel

IPC: A61K39/295 ,  A61K39/12 ,  A61P31/20

CPC classification number: A61K39/12 ,  A61K38/00 ,  A61K39/04 ,  A61K49/0004 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K14/005 ,  C12N2750/10034 ,  C12N2750/14043 ,  C12N2770/10034

Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein. Moreover, multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of PCV2 infection, preferably PCV2 ORF2 protein, or an immunogenic composition comprising PCV2 ORF2 protein, and at least one immunogenic active component of another disease-causing organism in swine,

Abstract translation: 提供了一种用于从猪圆环病毒2型开放阅读框架2回收蛋白质的改进方法。 还提供重组PCV2 ORF2蛋白和包含PCV2 ORF2蛋白的免疫原性组合物。 此外，提供了多价组合疫苗，其包括有效降低PCV2感染的严重性（优选PCV2 ORF2蛋白）或包含PCV2 ORF2蛋白的免疫原性组合物的发生率或降低的免疫学试剂，以及至少一种其它疾病的免疫原性活性成分 在猪中有机体，

公开(公告)号：US20080279875A1

公开(公告)日：2008-11-13

申请号：US12137067

申请日：2008-06-11

Applicant: Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

Inventor： Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

IPC: A61K39/00

CPC classification number: A61K39/12 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2750/10022 ,  C12N2750/10023 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2750/10071 ,  C12N2750/14143

Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.

公开(公告)号：US20110217327A1

公开(公告)日：2011-09-08

申请号：US13106606

申请日：2011-05-12

Applicant: Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

Inventor： Michael Roof ,  Phillip Hayes ,  Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

IPC: A61K39/12 ,  A61P31/12 ,  A61P37/04

CPC classification number: A61K39/12 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2750/10022 ,  C12N2750/10023 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2750/10071 ,  C12N2750/14143

Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.

Abstract translation: 本发明涉及包含用于治疗几种临床表现（疾病）的猪圆环病毒2型（PCV2）抗原的免疫原性组合物的用途。 优选地，临床表现与PCV2感染相关。 优选地，它们包括淋巴结病，淋巴细胞减少和/或多核/巨细胞组织细胞。 此外，临床症状包括与猪中的一种或多种以下症状相结合的淋巴结病：（1）间质性肺炎与小叶间水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝脏，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia样病变，通常已知与细胞内劳森氏菌感染有关。