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公开(公告)号：US20140235667A1
公开(公告)日：2014-08-21
申请号：US14346403
申请日：2012-09-17
发明人： Amjad Ali , D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Michael Lo , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Jerry Andrew Taylor , Brent Whitehead , Yusheng Xiong
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： This invention relates to imidazopyridyl compounds of the structural formula: I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译： 本发明涉及结构式为I或其药学上可接受的盐的咪唑并吡啶基化合物，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。
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公开(公告)号：US20170020879A1
公开(公告)日：2017-01-26
申请号：US15139361
申请日：2016-04-27
发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： A61K31/519 , A61K31/444 , C07D487/04 , C07D471/04
CPC分类号： A61K31/519 , A61K31/437 , A61K31/444 , C07D471/04 , C07D487/04
摘要： This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译： 或其药学上可接受的盐，其中所述变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。
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公开(公告)号：US09550786B2
公开(公告)日：2017-01-24
申请号：US14761170
申请日：2014-01-13
发明人： Andrew Cooke , Scott D. Kuduk , Craig Stump , Peter Williams
IPC分类号： C07D487/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
CPC分类号： C07D487/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention is directed to 4-fluoropiperidine compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的4-氟哌啶化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US09518055B2
公开(公告)日：2016-12-13
申请号：US14885187
申请日：2015-10-16
发明人： Amjad Ali , D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Michael Lo , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Jerry Andrew Taylor , Brent Whitehead , Yusheng Xiong
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： This invention relates to imidazopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
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公开(公告)号：US09193724B2
公开(公告)日：2015-11-24
申请号：US14346438
申请日：2012-09-17
发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Paul Ratcliffe , Jerry Andrew Taylor , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： This invention relates to triazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译： 本发明涉及结构式的三唑并吡啶基化合物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。
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公开(公告)号：US09567333B2
公开(公告)日：2017-02-14
申请号：US14886563
申请日：2015-10-19
发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Paul Ratcliffe , Jerry Andrew Taylor , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： This invention relates to triazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译： 本发明涉及结构式的三唑并吡啶基化合物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。
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公开(公告)号：US20160039817A1
公开(公告)日：2016-02-11
申请号：US14886563
申请日：2015-10-19
发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Paul Ratcliffe , Jerry Andrew Taylor , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： This invention relates to triazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译： 本发明涉及结构式的三唑并吡啶基化合物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。
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公开(公告)号：US20140288094A1
公开(公告)日：2014-09-25
申请号：US14346518
申请日：2012-09-17
发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D487/04 , A61K31/437 , A61K31/519 , C07D471/04
CPC分类号： A61K31/519 , A61K31/437 , A61K31/444 , C07D471/04 , C07D487/04
摘要： This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译： 本发明涉及以下结构式的吡唑并吡啶基化合物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。
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公开(公告)号：US09844553B2
公开(公告)日：2017-12-19
申请号：US15139361
申请日：2016-04-27
发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D487/04 , A61K31/519 , C07D471/04 , A61K31/437 , A61K31/444
CPC分类号： A61K31/519 , A61K31/437 , A61K31/444 , C07D471/04 , C07D487/04
摘要： This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
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公开(公告)号：US20160031882A1
公开(公告)日：2016-02-04
申请号：US14885187
申请日：2015-10-16
发明人： Amjad Ali , D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Michael Lo , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Jerry Andrew Taylor , Brent Whitehead , Yusheng Xiong
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： This invention relates to imidazopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译： 本发明涉及结构式的咪唑并吡啶基化合物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。
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